IL4R
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Official Full Name
interleukin 4 receptor -
Overview
This gene encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to regulate IgE production. The encoded protein also can bind interleukin 4 to promote differentiation of Th2 cells. A soluble form of the encoded protein can be produced by an alternate splice variant or by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. Allelic variations in this gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, sinusitus, asthma, or eczema. Two transcript variants encoding different isoforms, a membrane-bound and a soluble form, have been found for this gene. -
Synonyms
IL4R;interleukin 4 receptor;interleukin-4 receptor subunit alpha;CD124;IL-4 receptor subunit alpha;interleukin-4 receptor alpha chain;IL4RA;IL-4RA
Recombinant Proteins
- Human
- Cynomolgus
- Cynomolgus/Rhesus macaque
- Rat
- Pig
- Mus musculus
- HEK293
- E.coli
- HEK293 cells
- A293 cells
- Mammalian cells
- Mammalian Cell
- Human Cell
- CHO
- Yeast
- Wheat Germ
- In Vitro Cell Free System
- E.coli expression system
- Non
- His
- His&Avi
- Fc&Avi
- Fc
- His&SUMO
- GST
- His&Fc&Avi
Involved Pathway
IL4R involved in several pathways and played different roles in them. We selected most pathways IL4R participated on our site, such as Cytokine-cytokine receptor interaction,PIK-Akt signaling pathway,Jak-STAT signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IL4R were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| PIK-Akt signaling pathway | PPP2R3C,TSC2,FGFR3,CRTC2,MDM2,Pdgfa&Pdgfb,ITGA8,IRS1,ANGPT2,Il2 |
| Cytokine-cytokine receptor interaction | CCR9,IFNAR2,IL22RA1,CCL28,PLEKHO2,LEPR,TNFRSF10B,PRLR,IFNG1-2,ACVR1B |
| Hematopoietic cell lineage | IL1R2,Flt3l,CR1,CSF3,CD1D2,CD1E,IL5,Cd24a,CD1E,CD3E; CD3D |
| Jak-STAT signaling pathway | HRASB,OSM,IFNA12,STAT4,M17,IL9,GM-CSF,STAT1B,Il23a; Il12b,JAK2A |
| Inflammatory bowel disease (IBD) | NFATC1,IL12A,H2-AB1,HLA-DMA,IL23,IL2RG,IL21,HLA-DOB,Il23a,TNF |
Protein Function
IL4R has several biochemical functions, for example, interleukin-4 receptor activity,protein binding,receptor signaling protein activity. Some of the functions are cooperated with other proteins, some of the functions could acted by IL4R itself. We selected most functions IL4R had, and list some proteins which have the same functions with IL4R. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| receptor signaling protein activity | SMAD1,TRAIP,NCR1,NSMAF,KLK1B3,Siglece,RGS12,ADRB1,NGF,TGFBR1 |
| protein binding | BLZF1,TYRO3,ACTR3,PIK3CD,C12orf5,FURIN,VGLL4,MME,RBM11,NPEPL1 |
Interacting Protein
IL4R has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL4R here. Most of them are supplied by our site. Hope this information will be useful for your research of IL4R.
IL4;IL2RG;STAT6;IL13RA1
Resources
Research Area
Multiple Sclerosis and Myelin Related MoleculesNegative Regulators of the Jak/STAT Pathway
Receptors in the Jak/STAT Pathway
T Cell Cytokine Signaling
CD Antigen (Helper T Cells)
Asthma Therapeutic Targets
T Follicular Helper (Tfh) Cells
Th17 Cells
Th2 Cells
Th9 Cells
Common gamma Chain Family Receptors
MDSC Phenotyping - Positive Markers
Related Services
Related Products
References
- Biedermann, T; Werfel, T; et al. Status quo and prospects for systemic therapy of atopic dermatitis. Biologics ante portas. HAUTARZT 66:108-113(2015).
- Krabben, A; Huizinga, TWJ; et al. Biomarkers for Radiographic Progression in Rheumatoid Arthritis. CURRENT PHARMACEUTICAL DESIGN 21:147-169(2015).
