Active Recombinant Human IL4R Protein
| Cat.No. : | IL4R-01H |
| Product Overview : | CHO cell-derived Recombinant Human sIL-4 Receptor α corresponding to 209 amino acid residues of the extracellular domain of IL-4Rα without tag was expressed inn CHO. |
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| Description : | This gene encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to regulate IgE production. The encoded protein also can bind interleukin 4 to promote differentiation of Th2 cells. A soluble form of the encoded protein can be produced by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. Allelic variations in this gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, sinusitus, asthma, or eczema. Polymorphisms in this gene are also associated with resistance to human immunodeficiency virus type-1 infection. Alternate splicing results in multiple transcript variants. |
| Source : | CHO |
| Species : | Human |
| Bio-activity : | The ED50 was determined by its ability to inhibit the IL-4 dependent proliferation of human TF-1 cells is ≤ 5.0 ng/mL (in the presence of 0.5 ng/mL of IL-4), corresponding to a specific activity of ≥ 2 × 10^5 units/mg. |
| Molecular Mass : | 23.9 kDa |
| AA Sequence : | GNMKVLQEPTCVSDYMSISTCEWKMNGPTNCSTELRLLYQLVFLLSEAHTCIPENNGGAGCVCHLLMDDVVSADNYTLDLWAGQQLLWKGSFKPSEHVKPRAPGNLTVHTNVSDTLLLTWSNPYPPDNYLYNHLTYAVNIWSENDPADFRIYNVTYLEPSLRIAASTLKSGISYRARVRAWAQCYNTTWSEWSPSTKWHNSYREPFEQH |
| Purity : | ≥ 95% by SDS-PAGE gel and HPLC analyses. |
| Gene Name | IL4R interleukin 4 receptor [ Homo sapiens (human) ] |
| Official Symbol | IL4R |
| Synonyms | IL4R; interleukin 4 receptor; CD124; IL4RA; IL-4RA; interleukin-4 receptor subunit alpha; IL-4 receptor subunit alpha; IL4R nirs variant 1; interleukin 13 receptor; interleukin-4 receptor alpha chain |
| Gene ID | 3566 |
| mRNA Refseq | NM_000418 |
| Protein Refseq | NP_000409 |
| MIM | 147781 |
| UniProt ID | P24394 |
Not For Human Consumption!
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