IL15

  • Official Full Name

    interleukin 15

  • Overview

    Interleukin 15 (IL-15) is a cytokine with structural similarity to IL-2. Like IL-2, IL-15 binds to and signals through the IL-2/IL-15 beta chain (CD122) and the common gamma chain (gamma-C, CD132). IL-15 is secreted by mononuclear phagocytes (and some other cells) following infection by virus(es). This cytokine induces cell proliferation of natural killer cells; cells of the innate immune system whose principal role is to kill virally infected cells.

  • Synonyms

    IL15;MGC9721;Interleukin-15 precursor;OTTHUMP00000164617;interleukin 15;IL-15

Recombinant Proteins

  • Human
  • Feline
  • Equine
  • Mouse
  • Cynomolgus/Rhesus macaque
  • Porcine
  • Chicken
  • Rhesus macaque
  • Rat
  • Bovine
  • Pig
  • Zebrafish
  • Guinea Pig
  • Cattle
  • Guinea pig
  • Sheep
  • Rabbit
  • Goat
  • Golden hamster
  • E.coli
  • CHO
  • Yeast
  • HEK293
  • Mouse
  • Mammalian Cells
  • Sf21 Cells
  • Human Cells
  • Non
  • Fc
  • His
  • Strep II
  • His&S
  • Avi&His
  • Avi&Fc
  • DDK&Myc
  • Flag
  • Avi&Fc&His
  • Fc&Myc
  • His&Strep II
Cat.# Product name Source (Host) Species Tag Protein Length Price
IL15-25H Active Recombinant Human IL15 E.coli Human Non
IL15-24H Recombinant Human IL15 protein E.coli Human Non 114
Il15-001H Active Recombinant Human Il15, HIgG1 Fc-tagged, mutant CHO Human Fc 49-162 a.a.
Il15-002H Active Recombinant Human Il15, MIgG2a Fc-tagged CHO Human Fc 49-162 a.a.
IL15-006H Active Recombinant Human IL15, HIgG1 Fc-tagged CHO Human Fc 49-162 a.a.
IL15-1099F Active Recombinant Feline IL15 E.coli Feline Non Asn49-Ser162
IL15-253E Active Recombinant Equine Interleukin 15 Yeast Equine Non
IL15-271H Active Recombinant Human IL15 protein HEK293 Human Non Asn 49 - Ser 162
IL15-306H Active Recombinant Human IL15 protein, His-tagged E.coli Human His Asn49-Ser162
IL15-330H Active Recombinant Human IL15, Fc-tagged CHO Human Fc 49-162 a.a.
Il15-423M Active Recombinant Mouse Interleukin 15, His-tagged Mouse Mouse His 49-162 a.a.
IL15-483H Active Recombinant Human Interleukin 15 E.coli Human Non
Il15-484M Active Recombinant Mouse Interleukin 15 E.coli Mouse Non
Il15-533M Active Recombinant Mouse Interleukin 15, His-tagged Mouse Mouse His
Il15-739M Active Recombinant Mouse Interleukin 15, His-tagged E.coli Mouse His 49-162aa
IL15-0177C Active Recombinant Cynomolgus / Rhesus macaque IL15 protein, His-tagged HEK293 Cynomolgus/Rhesus macaque His 49-162 a.a.
IL15-01HG Active GMP Recombinant Human IL15 Protein CHO Human
Il15-01M Active Recombinant Mouse Il15 Protein, His-Tagged E.coli Mouse His
IL15-01P Active GMP Recombinant Porcine IL15 Protein, His-Tagged E.coli Porcine His
IL15-2177H Active Recombinant Human IL15 protein, His-tagged HEK293 Human His Asn 49 - Ser 162
IL15-004H Active Recombinant Human IL15 Protein, His-tagged E.coli Human His 49-162 a.a.
IL15-125H Recombinant Human IL15 protein E.coli Human Non
IL15-20C Recombinant Chicken IL-15 Yeast Chicken Non
IL15-2232R Recombinant Rhesus monkey IL15 Protein, His-tagged Mammalian Cells Rhesus macaque His
Il15-231R Recombinant Rat Interleukin 15 Sf21 Cells Rat Non
IL15-235B Recombinant Bovine Interleukin 15 Yeast Bovine Non
IL15-263S Recombinant Swine IL15 Yeast Pig Non
IL15-270H Recombinant Human IL15, StrepII-tagged Human Cells Human Strep II 30-162, 133 a.a.
IL15-28238TH Recombinant Human IL15, His-tagged E.coli Human His 49-162 a.a.
IL15-3028R Recombinant Rat IL15 Protein Mammalian Cells Rat His
IL15-3624Z Recombinant Zebrafish IL15 Mammalian Cells Zebrafish His
IL15-6140C Recombinant Chicken IL15 Mammalian Cells Chicken His
Il15-69M Recombinant Mouse Interleukin 15 E.coli Mouse Non
IL15-80G Recombinant Guinea Pig IL-15 Yeast Guinea Pig Non
IL15-80P Recombinant Porcine Interleukin-15 E.coli Pig Non
IL15-8119M Recombinant Mouse IL15 Protein Mammalian Cells Mouse His
IL15-859C Recombinant Cattle IL15 protein, His-tagged E.coli Cattle His Ala48~Ser162
Il15-860G Recombinant Guinea pig Il15 protein, His & S-tagged E.coli Guinea pig His&S Ser49~Ser162
IL15-861S Recombinant Sheep IL15 protein, His-tagged E.coli Sheep His Asn49~Ser162
IL15-863R Recombinant Rabbit IL15 protein, His-tagged E.coli Rabbit His Asn49~Pro162
Il15-88R Recombinant Rat Interleukin 15 E.coli Rat Non
IL15-5248HCL Recombinant Human IL15 293 Cell Lysate HEK293 Human Non
IL15-0176H Active Recombinant Human IL15 protein, His-Avi-tagged, Biotinylated HEK293 Human Avi&His 49-162 a.a.
IL15-0178M Active Recombinant Mouse IL15 protein, Fc-tagged HEK293 Mouse Fc 49-162 a.a.
IL15-0179M Active Recombinant Mouse IL15 protein, Fc-Avi-tagged, Biotinylated HEK293 Mouse Avi&Fc 49-162 a.a.
IL15-01R Recombinant Rhesus Monkey IL15 Protein, His-tagged Yeast Rhesus macaque His 49-162 a.a.
IL15-05HG Active Recombinant Human IL15 Protein (Asn49-Ser162), GMP Grade, Animal-Free E.coli Human Asn49-Ser162
IL15-063H Active Recombinant Human IL15 Protein E.coli Human 49-162 a.a.
Il15-091M Active Recombinant Mouse Il15 Protein E.coli Mouse
Il15-092M Recombinant Mouse Il15 Protein, MYC/DDK-tagged HEK293 Mouse DDK&Myc
IL15-1004P Recombinant Pig IL15 Protein, His-tagged E.coli Pig His Thr49-Ser162
il15-1005Z Recombinant Zebrafish il15 Protein, His-tagged E.coli Zebrafish His Met1-Glu141
IL15-1006C Recombinant Chicken IL15 Protein, His-tagged E.coli Chicken His Asn67-Asn187
IL15-100H Active Recombinant Human IL15 Protein E.coli Human Asn49-Ser162
IL15-134H Active Recombinant Human IL15 Protein E.coli Human
IL15-145H Recombinant Active Human IL15 Protein, His-tagged(N-ter) E.coli Human His
Il15-146M Recombinant Active Mouse IL15 Protein, His-tagged(N-ter) E.coli Mouse His
IL15-147H Human Interleukin-15(rDNA derived) Reference standard Human Non
IL15-147P Recombinant Active Pig IL15 Protein, His-tagged(N-ter) E.coli Pig His
IL15-150H Recombinant Human IL15 Protein, Mature chain, Tag Free, Biotinylated HEK293 Human Non Mature chain
IL15-151H Recombinant Human IL15 Protein, DYKDDDDK-tagged Human Cells Human Flag
IL15-180H Active Recombinant Human IL15 Protein (Asn49-Ser162), N-His tagged, Animal-free, Carrier-free E.coli Human His Asn49-Ser162
IL15-2053R Recombinant Rhesus Macaque IL15 Protein, His (Fc)-Avi-tagged HEK293 Rhesus macaque Avi&Fc&His
IL15-2053R-B Recombinant Rhesus Macaque IL15 Protein Pre-coupled Magnetic Beads HEK293 Rhesus macaque
IL15-212P Active Recombinant Pig IL15 Protein (Thr49-Ser162), N-His tagged, Animal-free, Carrier-free E.coli Pig His Thr49-Ser162
IL15-21HG Active Recombinant Human IL15 Protein (Asn49-Ser162), GMP Grade, Animal-Free E.coli Human Asn49-Ser162
IL15-2291G Recombinant Goat IL15 Protein, His-tagged E.coli Goat His Thr27-Ser161
IL15-2473H Recombinant Human IL15 Protein (Met21-Gly133), His tagged E.coli Human His Met21-Gly133
IL15-2474H Recombinant Human IL15 Protein (Asn49-Ser162), C-His tagged E.coli Human His Asn49-Ser162
IL15-2683R Recombinant Rat IL15 Protein, His (Fc)-Avi-tagged HEK293 Rat Avi&Fc&His
IL15-2683R-B Recombinant Rat IL15 Protein Pre-coupled Magnetic Beads HEK293 Rat
IL15-26H Active Recombinant Human IL15 Protein, Animal Free Human Cells Human
IL15-272H Active Recombinant Human IL15 protein, Fc-Avi-tagged, Biotinylated HEK293 Human Avi&Fc 49-162 a.a.
IL15-321H Recombinant Human IL15 protein HEK293 Human 114
IL15-336HG Active GMP Recombinant Human IL15 Protein E.coli Human 49-162 a.a.
IL15-337HG Active GMP Recombinant Human IL15 protein CHO Human
IL15-35HG Recombinant Human IL15 Protein, GMP Grade, Animal-Free E.coli Human
IL15-369I Active Recombinant Human IL15 Protein (114 aa) E.coli Human 114
IL15-370I Active Recombinant Human IL15 Protein (121 aa), His-tagged E.coli Human His 121
IL15-382H Recombinant Human IL15 protein E.coli Human Non Asn49-Ser162
IL15-4329HG GMP Recombinant Human IL15 protein E.coli Human Non 114
IL15-4494M Recombinant Mouse IL15 Protein, His (Fc)-Avi-tagged HEK293 Mouse Avi&Fc&His
IL15-4494M-B Recombinant Mouse IL15 Protein Pre-coupled Magnetic Beads HEK293 Mouse
IL15-507H Recombinant Human IL15 Protein Human 291
Il15-50M Active Recombinant Mouse Il15 Protein (Asn49-Ser162), N-His tagged, Animal-free, Carrier-free E.coli Mouse His Asn49-Ser162
IL15-5922H Recombinant Human IL15 protein, hFc-Myc-tagged HEK293 Human Fc&Myc 49-162aa
IL15-6361H Recombinant Human IL15 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293 Human DDK&Myc
Il15-647M Recombinant Mouse Il15 protein, Fc-tagged HEK293 Mouse Fc Asn49-Ser162
Il15-7234M Active Recombinant Mouse Il15 Protein, His-tagged E.coli Mouse His
Il15-784G Recombinant Golden hamster Il15 protein, His&Strep II-tagged E.coli Golden hamster His&Strep II 30-162a.a.

    Involved Pathway

    IL15 involved in several pathways and played different roles in them. We selected most pathways IL15 participated on our site, such as Cytokine-cytokine receptor interaction,Jak-STAT signaling pathway,TNF signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IL15 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    ne network for IgA production CCL27B,TNFRSF17,HLA-DMA,CXCL12B,BLB1,BMA1,CCR9A,CXCR4A,CXCL12,CD86
    Intestinal i CCL28,Icosl,BMA2,CD80,CD40,HLA-DQA1,BMA1,HLA-DQA2,HLA-DRB1,BLB1
    Cytokine-cytokine receptor interaction CCL27B,Flt3l,LIF,Ccl21c,Ifna15,PRP2,IL17RB,CXCR6,TGFB1A,CXCR5
    Herpes simplex infection MAPK10,EIF2AK4,IL6,CASP3B,C5,NFKBIAB,PPP1CAB,C3A.2,OAS2,HLA-A
    TNF signaling pathway MAPK12,MAP2K7,MAPK1,DNM1L,PIK3R5,LTA,TRADD,MAP2K6,MMP3,MAP2K3
    HTLV-I infection NFATC4,RELB,TP53INP1,TGFB1,CCND1,Adcy4,RANBP3,TBPL2,H2-AA,RRAS
    Rheumatoid arthritis ATP6V0D2,TGFB3,Il23a; Il12b,FOS,CCL5,ATP6V0A4,ATP6V1F,TNFSF13B,ATP6V0D1,CTLA4
    Jak-STAT signaling pathway PIAS1,IL3,PIK3R1,Il4ra,OSMR,LEP,LIFR,IFNE,CRFB4,IL4

    Protein Function

    IL15 has several biochemical functions, for example, cytokine activity,cytokine receptor binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IL15 itself. We selected most functions IL15 had, and list some proteins which have the same functions with IL15. You can find most of the proteins on our site.

    Function Related Protein
    protein binding NOL6,DDX41,MAVS,ASCL4,IGFBP3,SNRPA1,CCL28,MYLK,SAFB2,SLX4IP
    cytokine activity IFNA14,TNFSF15,IL10,IL17F,FAM3B,Ifnz,IL17B,IL21,Ctf2,INHA
    cytokine receptor binding IFNA13,IFNPHI1,IFNPHI3,IFNPHI2,IFNT2,IFNA14,IFNA8,IL17A/F3,IL17F,IL17A/F2

    Interacting Protein

    IL15 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL15 here. Most of them are supplied by our site. Hope this information will be useful for your research of IL15.

    IL2RB;IL15RA;STAT5B;TRAF3;ZNRD1

    Resources

    Gene Families

    What is the interleukin (IL) factors and IL gene family

    Research Area

    Natural Killer Cell (NK Cell)
    Negative Regulators of the Jak/STAT Pathway
    Receptors in the Jak/STAT Pathway
    Cytokines and Growth Factors Secreted by VSMC
    Natural Killer T (NKT) Cells
    Regulatory T Cells (Tregs)
    Rheumatoid arthritis Therapeutic Targets
    Common gamma Chain Receptor Family Ligands
    Common gamma Chain Family Ligands

    References

    • Krabben, A; Huizinga, TWJ; et al. Biomarkers for Radiographic Progression in Rheumatoid Arthritis. CURRENT PHARMACEUTICAL DESIGN 21:147-169(2015).
    • Britze, A; Palmfeldt, J; et al. 44-plex cytokine profile of cholesteatoma. ACTA OTO-LARYNGOLOGICA 134:41-50(2014).

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