HB-EGF
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Official Full Name
heparin-binding EGF-like growth factor -
Overview
Heparin-binding EGF-like growth factor (HB-EGF) is a member of the EGF family of proteins that in humans is encoded by the HBEGF gene. HB-EGF-like growth factor is synthesized as a membrane-anchored mitogenic and chemotactic glycoprotein. An epidermal growth factor produced by monocytes and macrophages, due to an affinity for heparin is termed HB-EGF. It has been shown to play a role in wound healing, cardiac hypertrophy and heart development and function.[1] First identified in the conditioned media of human macrophage-like cells, HB-EGF is an 87 amino acid glycoprotein which displays highly regulated gene expression.[2] Ectodomain shedding results in the soluble mature form of HB-EGF which influences the mitogenicity and chemotactic factors for smooth muscle cells and fibroblasts. The transmembrane form of HB-EGF is the unique receptor for diphtheria toxin and functions in juxtacrine signaling in cells. Both forms of HB-EGF participate in normal physiological processes and in pathological processes including tumor progression and metastasis, organ hyperplasia, and atherosclerotic disease. HB-EGF can bind two locations on cell surfaces, heparan sulfate proteoglycans and EGF-receptor effecting cell to cell interactions. -
Synonyms
DTR;DTS;DTSF;HEGFL
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Involved Pathway
HB-EGF involved in several pathways and played different roles in them. We selected most pathways HB-EGF participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with HB-EGF were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
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Protein Function
HB-EGF has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by HB-EGF itself. We selected most functions HB-EGF had, and list some proteins which have the same functions with HB-EGF. You can find most of the proteins on our site.
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Interacting Protein
HB-EGF has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HB-EGF here. Most of them are supplied by our site. Hope this information will be useful for your research of HB-EGF.
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