Active Recombinant Human HBEGF Protein

• Cat.No.: HBEGF-056H
• Product Overview: The mature recombinant human HB-EGF protein containing 46aa (D63-L148) without tag was expressed in E. coli.

Specification

• Species: Human
• Source: E.coli
• Protein Length: 63-148 a.a.
• Description: Growth factor that mediates its effects via EGFR, ERBB2 and ERBB4. Required for normal cardiac valve formation and normal heart function. Promotes smooth muscle cell proliferation. May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts, but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Also acts as a diphtheria toxin receptor.
• Bio-activity: Measured in a cell proliferation assay using Balb/3T3 mouse embryonic fibroblast cells. The ED50 for this effect is 0.15-0.75 ng/mL
• Molecular Mass: 9.7 kDa
• Product-Related Proteins: 63-148
• Endotoxin: < 0.1 EU/μg of the protein as determined by the LAL method
• Purity: > 95 % as determined by SDS-PAGE
• Storage: At -80 centigrade. Avoid repeated freeze-thaw cycles.
• Storage Buffer: PBS

Gene Information

• Gene Name: HBEGF heparin binding EGF like growth factor [ Homo sapiens (human) ]
• Official Symbol: HBEGF
• Synonyms: HBEGF; heparin binding EGF like growth factor; DTR; DTS; DTSF; HEGFL; proheparin-binding EGF-like growth factor; Names; diphtheria toxin receptor (heparin-binding EGF-like growth factor); diphtheria toxin receptor (heparin-binding epidermal growth factor-like growth factor); heparin-binding epidermal growth factor
• Gene ID: 1839
• mRNA Refseq: NM_001945
• Protein Refseq: NP_001936
• MIM: 126150
• UniProt ID: Q99075