Recombinant Human HBEGF, GST-tagged

• Cat.No.: HBEGF-13682H
• Product Overview: Recombinant Human HBEGF protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose.

Specification

• Source: E.coli
• Species: Human
• Tag: GST
• Protein length: 25-162a.a.
• Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
• Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol.

Gene Information

• Gene Name: HBEGF heparin-binding EGF-like growth factor [ Homo sapiens ]
• Official Symbol: HBEGF
• Synonyms: HBEGF; heparin-binding EGF-like growth factor; diphtheria toxin receptor (heparin binding epidermal growth factor like growth factor) , DTR, DTS, HEGFL; proheparin-binding EGF-like growth factor; Diphtheria toxin receptor (heparin binding EGF like growth factor); heparin binding epidermal growth factor; heparin-binding epidermal growth factor; diphtheria toxin receptor (heparin-binding EGF-like growth factor); diphtheria toxin receptor (heparin-binding epidermal growth factor-like growth factor); DTR; DTS; DTSF; HEGFL
• Gene ID: 1839
• mRNA Refseq: NM_001945
• Protein Refseq: NP_001936
• MIM: 126150
• UniProt ID: Q99075
• Chromosome Location: 5q23
• Pathway: Epithelial cell signaling in Helicobacter pylori infection, organism-specific biosystem; Epithelial cell signaling in Helicobacter pylori infection, conserved biosystem; ErbB receptor signaling network, organism-specific biosystem; ErbB signaling pathway, organism-specific biosystem; ErbB signaling pathway, organism-specific biosystem; ErbB signaling pathway, conserved biosystem; ErbB4 signaling events, organism-specific biosystem
• Function: epidermal growth factor receptor binding; eukaryotic cell surface binding; growth factor activity; heparin binding; receptor activity

Reviews

01/14/2019

Reliable peptide synthesis; accelerates our peptide-based projects.

10/08/2018

Efficient protein purification; consistent yields, cost-effective.

01/30/2018

Precise protein quantification; ensures data accuracy in our experiments.

Q&As

How does HBEGF influence cancer cell growth, migration, and invasion?

HBEGF enhances cancer progression by facilitating tumor cell growth, migration, and invasion.

How does HBEGF interact with its receptors, and what are the downstream signaling pathways involved?

HBEGF binds to specific receptors, triggering signaling pathways that affect cell growth, survival, and differentiation.

How do changes in HBEGF expression affect skin homeostasis and the development of skin diseases?

Variations in HBEGF expression impact skin health, influencing processes like repair and the development of skin disorders.

What is the impact of HBEGF in developmental processes, particularly in embryogenesis and organogenesis?

HBEGF is crucial in embryogenesis and organ development, guiding cell differentiation and organ formation.

What are the mechanisms by which HBEGF modulates cellular responses in inflammation and immune regulation?

HBEGF modulates inflammation and immune responses, influencing cellular behavior in immune processes.

What role does HBEGF play in cardiovascular diseases, particularly in cardiac hypertrophy and atherosclerosis?

In cardiovascular diseases, HBEGF is involved in processes like cardiac hypertrophy and atherosclerotic lesion formation.

How does HBEGF contribute to the process of wound healing and tissue regeneration?

HBEGF promotes wound healing and tissue regeneration by stimulating cell proliferation and migration.