ERBB4

  • Official Full Name

    v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)

  • Overview

    c-erbB-4 is the fourth member of class 1 receptor kinase family. HER-4 is most predominantly expressed in several breast carcinoma cell lines, and in normal skeletal muscle, heart, pituitary, brain, and cerebellum. Breast tumor cell lines T47-D, MDA-MB-453, BT-474 and H3396 are found to have the highest levels of mRNA, and intermediate levels are seen in MCF-7, MDA-MB-330 and MDA-MB-361. Expression of erbB-4 is low or absent in some breast tumor cell lines such as MDA-MB-231, MDA-MB-157, MDA-MB-468, and SKBR-3.

  • Synonyms

    ERBB4;v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian);v erb a avian erythroblastic leukemia viral oncogene homolog like 4;receptor tyrosine-protein kinase erbB-4;proto-oncogene-like protein c-ErbB-4;tyrosine kinase-type cell surface receptor HER4;avian erythroblastic leukemia viral (v-erb-b2) oncogene homolog 4;HER4;p180erbB4;MGC138404

Recombinant Proteins

  • Mouse
  • Human
  • Rat
  • Chicken
  • Human/Rhesus macaque
  • HEK293
  • Human Cell
  • Insect Cell
  • E.coli
  • Mammalian cells
  • C-His-Avi
  • Sf9 Insect Cell
  • Mammalian Cell
  • Wheat Germ
  • CHO
  • HEK293T
  • In Vitro Cell Free System
  • His
  • His&Fc
  • GST
  • Fc
  • Non
  • Flag
  • His&Avi
  • His&Flag
  • His&Fc&Avi
  • Myc&DDK
Cat.# Product name Source (Host) Species Tag Protein Length Price
Erbb4-7416MAF488 Active Recombinant Mouse Erbb4 Protein, His-tagged, Alexa Fluor 488 conjugated HEK293 Mouse His Met1-Leu652， 638
Erbb4-7416MAF555 Active Recombinant Mouse Erbb4 Protein, His-tagged, Alexa Fluor 555 conjugated HEK293 Mouse His Met1-Leu652， 638
Erbb4-7416MAF647 Active Recombinant Mouse Erbb4 Protein, His-tagged, Alexa Fluor 647 conjugated HEK293 Mouse His Met1-Leu652， 638
Erbb4-7416MF Active Recombinant Mouse Erbb4 Protein, His-tagged, FITC conjugated HEK293 Mouse His Met1-Leu652， 638
ERBB4-288H Recombinant Human ERBB4, Fc-His tagged Human Cell Human His&Fc 1-651 a.a.
ErbB4-7283H Recombinant Human ErbB4 Protein, His-tagged HEK293 Human His Gln26-Arg649
ERBB4-216HAF488 Recombinant Human ERBB4 Protein, His-tagged, Alexa Fluor 488 conjugated Insect Cell Human His Met1-Arg649， 635
ERBB4-216HAF555 Recombinant Human ERBB4 Protein, His-tagged, Alexa Fluor 555 conjugated Insect Cell Human His Met1-Arg649， 635
ERBB4-216HAF647 Recombinant Human ERBB4 Protein, His-tagged, Alexa Fluor 647 conjugated Insect Cell Human His Met1-Arg649， 635
ERBB4-216HF Recombinant Human ERBB4 Protein, His-tagged, FITC conjugated Insect Cell Human His Met1-Arg649， 635
ERBB4-217RAF488 Recombinant Rat Erbb4 Protein, His-tagged, Alexa Fluor 488 conjugated HEK293 Rat His 637
ERBB4-217RAF555 Recombinant Rat Erbb4 Protein, His-tagged, Alexa Fluor 555 conjugated HEK293 Rat His 637
ERBB4-217RAF647 Recombinant Rat Erbb4 Protein, His-tagged, Alexa Fluor 647 conjugated HEK293 Rat His 637
ERBB4-217RF Recombinant Rat Erbb4 Protein, His-tagged, FITC conjugated HEK293 Rat His 637
ERBB4-288HAF488 Recombinant Human ERBB4 Protein, Fc/His-tagged, Alexa Fluor 488 conjugated HEK293 Human His&Fc 871
ERBB4-288HAF555 Recombinant Human ERBB4 Protein, Fc/His-tagged, Alexa Fluor 555 conjugated HEK293 Human His&Fc 871
ERBB4-288HAF647 Recombinant Human ERBB4 Protein, Fc/His-tagged, Alexa Fluor 647 conjugated HEK293 Human His&Fc 871
ERBB4-288HF Recombinant Human ERBB4 Protein, Fc/His-tagged, FITC conjugated HEK293 Human His&Fc 871
ERBB4-3768H Recombinant Human ERBB4 protein, GST-tagged E.coli Human GST 989-1308 aa
ErbB4-7282HAF488 Recombinant Human ERBB4 Protein, Fc-tagged, Alexa Fluor 488 conjugated HEK293 Human Fc 865
ErbB4-7282HAF555 Recombinant Human ERBB4 Protein, Fc-tagged, Alexa Fluor 555 conjugated HEK293 Human Fc 865
ErbB4-7282HAF647 Recombinant Human ERBB4 Protein, Fc-tagged, Alexa Fluor 647 conjugated HEK293 Human Fc 865
ErbB4-7282HF Recombinant Human ERBB4 Protein, Fc-tagged, FITC conjugated HEK293 Human Fc 865
ErbB4-7283HAF488 Recombinant Human ErbB4 Protein, His-tagged, Alexa Fluor 488 conjugated HEK293 Human His 635
ErbB4-7283HAF555 Recombinant Human ErbB4 Protein, His-tagged, Alexa Fluor 555 conjugated HEK293 Human His 635
ErbB4-7283HAF647 Recombinant Human ErbB4 Protein, His-tagged, Alexa Fluor 647 conjugated HEK293 Human His 635
ErbB4-7283HF Recombinant Human ErbB4 Protein, His-tagged, FITC conjugated HEK293 Human His 635
Erbb4-8720RAF488 Recombinant Rat Erbb4 Protein, Fc-tagged, Alexa Fluor 488 conjugated HEK293 Rat Fc 867
Erbb4-8720RAF555 Recombinant Rat Erbb4 Protein, Fc-tagged, Alexa Fluor 555 conjugated HEK293 Rat Fc 867
Erbb4-8720RAF647 Recombinant Rat Erbb4 Protein, Fc-tagged, Alexa Fluor 647 conjugated HEK293 Rat Fc 867
Erbb4-8720RF Recombinant Rat Erbb4 Protein, Fc-tagged, FITC conjugated HEK293 Rat Fc 867
Erbb4-473M Active Recombinant Mouse V-Erb-A Erythroblastic Leukemia Viral Oncogene Homolog 4 (avian) Mammalian cells Mouse Non 26-657 a.a.
ERBB4-622H Active Recombinant Human ERBB4, His-tagged, Biotinylated Human Cell Human His 26-651 a.a.
ERBB4-623H Active Recombinant Human ERBB4, Fc-tagged, Biotinylated Human Cell Human Fc 26-651 a.a.
ErbB4-1253R Acitve Recombinant Rat ErbB4 protein(Met1-Pro651), His-tagged HEK293 Rat His Met1-Pro651
ERBB4-1621H Recombinant Human ERBB4 protein, His-Avi-tagged, Biotinylated C-His-Avi Human Non Gln26-Pro651
ERBB4-513HFL Active Recombinant Full Length Human ERBB4 Protein, C-Flag-tagged Mammalian cells Human Flag Full L.
ERBB4-6744H Recombinant Human ERBB4 protein, His-Avi-tagged HEK293 Human His&Avi Gln26-Pro651
ERBB4-1126H Recombinant Human V-Erb-A Erythroblastic Leukemia Viral Oncogene Homolog 4 (avian), GST-tagged Sf9 Insect Cell Human GST
ERBB4-1218H Recombinant Human V-Erb-A Erythroblastic Leukemia Viral Oncogene Homolog 4 (avian), GST-tagged Insect Cell Human GST 708-993 a.a.
ERBB4-139H Recombinant Human ERBB4 Protein, DDK-tagged Insect Cell Human Flag
ERBB4-140H Recombinant Human ERBB4 Protein, DDK-tagged Insect Cell Human Flag Met-Gln26-Pro651
ERBB4-141H Recombinant Human ERBB4 Protein, DDK/HIS-tagged HEK293 Human His&Flag Leu33-Val532
ERBB4-2134R Recombinant Rat ERBB4 Protein Mammalian Cell Rat His
ERBB4-216H Recombinant Human ERBB4, His-tagged Insect Cell Human His Met1-Arg649
ERBB4-217R Recombinant Rat Erbb4, His tagged Human Cell Rat His 1-651 a.a.
ERBB4-2237C Recombinant Chicken ERBB4 Mammalian Cell Chicken His
ERBB4-233H Recombinant Human ERBB4, C13&N15-labeled HEK293 Human Non 26-651 a.a.
ERBB4-26848TH Recombinant Human ERBB4 Human Non 682-993 a.a.
ERBB4-329H Recombinant Human ERBB4, GST-tagged, Active Sf9 Insect Cell Human GST 682-993 a.a.
ERBB4-3450H Active Recombinant Human ERBB4 Protein, GST-tagged Insect Cell Human GST
ERBB4-3451H Recombinant Human ERBB4 Protein, GST-tagged Wheat Germ Human GST
ErbB4-7282H Active Recombinant Human, Rhesus ErbB4 protein, hFc-tagged HEK293 Human/Rhesus macaque Fc Met1-Arg649
ERBB4-7284H Active Recombinant Human ERBB4 protein, His-tagged HEK293 Human His Gln26-Pro651
Erbb4-7416M Active Recombinant Mouse Erbb4 Protein, His tagged HEK293 Mouse His Met1-Leu652
Erbb4-8720R Active Recombinant Rat Erbb4 protein(Met1-Pro651), hFc-tagged HEK293 Rat Fc Met1-Pro651
ERBB4-001HCL Recombinant Human ERBB4 cell lysate Insect Cell Human Non
ERBB4-1417MCL Recombinant Mouse ERBB4 cell lysate Human Cell Mouse Non
ERBB4-1543HCL Recombinant Human ERBB4 cell lysate Human Cell Human Non
ERBB4-895RCL Recombinant Rat ERBB4 cell lysate Human Cell Rat Non
ERBB4-04H Active Recombinant Human ERBB4 Protein, hIgG/His-tagged HEK293 Human His&Fc 26-649 a.a.
Erbb4-10551M Recombinant Mouse Erbb4 Protein, His (Fc)-Avi-tagged HEK293 Mouse His&Fc&Avi
Erbb4-10551M-B Recombinant Mouse Erbb4 Protein Pre-coupled Magnetic Beads HEK293 Mouse
ERBB4-116H Recombinant Human ERBB4 Protein, ECD, Tag Free, Biotinylated CHO Human Non ECD
ERBB4-1325S Recombinant Human ERBB4 Protein (R676-V1308), Tag Free Insect Cell Human Non R676-V1308
ERBB4-1326S Recombinant Human ERBB4 Protein (R676-V1308), GST tagged Insect Cell Human GST R676-V1308
ErbB4-1400H Recombinant Human ErbB4 protein, hFc-tagged HEK293 Human Fc Gln26-Pro651
ERBB4-1791R Recombinant Rat ERBB4 Protein, His (Fc)-Avi-tagged HEK293 Rat His&Fc&Avi
ERBB4-1791R-B Recombinant Rat ERBB4 Protein Pre-coupled Magnetic Beads HEK293 Rat
ERBB4-2052H Recombinant Human ERBB4 Protein, Fc/His-tagged HEK293 Human His&Fc Gln26-Arg649
ERBB4-2116H Recombinant Human ERBB4 Protein, MYC/DDK-tagged HEK293 Human Myc&DDK
ERBB4-239H Recombinant Human ERBB4 Protein, His-tagged HEK293 Human His 1308
ERBB4-240H Recombinant Human ERBB4 Protein, Fc-tagged HEK293 Human Fc 1308
ERBB4-2651H Active Recombinant Human ERBB4 protein, hFc&His-tagged HEK293 Human His&Fc Gln26-Arg649
ERBB4-2678H Recombinant Human ERBB4 Protein (Cys29-Asn278), His tagged E.coli Human His Cys29-Asn278
ERBB4-358H Recombinant Human ERBB4 protein, Fc-tagged HEK293 Human Fc 626
ERBB4-385H Recombinant Human ERBB4 Protein, His-tagged E.coli Human His Cys29~Asn278
ERBB4-4240H Recombinant Human ERBB4 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Human Myc&DDK
ERBB4-4524HF Recombinant Full Length Human ERBB4 Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 1308 amino acids
ERBB4-69H Recombinant Human ERBB4 Protein (ECD), Fc-His-tagged(C-ter) HEK293 Human His&Fc Gln26-Arg649
ERBB4-859H Recombinant Human ERBB4 Protein, His (Fc)-Avi-tagged HEK293 Human His&Fc&Avi
ERBB4-859H-B Recombinant Human ERBB4 Protein Pre-coupled Magnetic Beads HEK293 Human
Erbb4-971M Recombinant Mouse Erbb4 Protein, MYC/DDK-tagged HEK293T Mouse Myc&DDK

    Involved Pathway

    ERBB4 involved in several pathways and played different roles in them. We selected most pathways ERBB4 participated on our site, such as ErbB signaling pathway,Calcium signaling pathway,Endocytosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with ERBB4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Endocytosis SMAP1,SH3GLB2A,ZFYVE16,BF2,EHD1A,RHOAA,ITCHA,ACAP1,VPS26A,DNM1B
    ErbB signaling pathway MAP2K2A,MYCB,PAK7,PTK2AB,PRKCG,HRAS,NCK2A,PTK2,EGFRA,MAPK9
    Calcium signaling pathway SPHK1,P2RX1,PLCD3,ATP2A1L,F2R,TACR1,EDNRB2,PHKA1,CALM3B,BDKRB1
    Proteoglycans in cancer ITGB3,CTTN,MAPK1,PTCH1,PPP1R12A,PIK3CB,FGFR1,WNT8B,WNT3A,WNT7B

    Protein Function

    ERBB4 has several biochemical functions, for example, ATP binding,epidermal growth factor receptor binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ERBB4 itself. We selected most functions ERBB4 had, and list some proteins which have the same functions with ERBB4. You can find most of the proteins on our site.

    Function Related Protein
    epidermal growth factor receptor binding VAV3,ATXN2,VAV2,AGR2,ARF4,TNK2,EREG,FER,FAM83B,HBEGF
    protein homodimerization activity CITED1,SETMAR,CARD8,ACTN1,TGFB1,IKBKG,KLRB1B,LDB1,GLIPR2,SUPV3L1
    ATP binding ACTG2,CKMA,RYK,Fert2,CTPS2,STK36,KCNJ8,GRK1A,XRCC5,PFKM
    transmembrane receptor protein tyrosine kinase activity RET,INSRR,INSRA,FLT1,ERBB4A,TIE1,IGF1RB,FGFR1A,KITA,EGFR
    receptor signaling protein tyrosine kinase activity TYRO3,KITA,KITB,ERBB3B,EGFR,LYN,EGFRA,ERBB2,KIT,ERBB4A
    protein binding UBE3A,TMEM119,TECPR1,CREB5,TGFA,FBXL15,CCDC55,PSMB7,GH1,LBH
    transcription regulatory region DNA binding CDK9,TBX21,ARID4A,TOMM20A,JUN,BCL11AB,H2AFY,FOXA1,CCNT1,TNF
    protein tyrosine kinase activity ABL1,MAP3K11,FGFR1B,FGFR1A,AXL,PDGFRB,BTK,Fert2,DYRK1A,JAK2A

    Interacting Protein

    ERBB4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ERBB4 here. Most of them are supplied by our site. Hope this information will be useful for your research of ERBB4.

    ERBB2;DLG4;SHC1;ERBB3;GRB2

    Resources

    Research Area

    Cancer Drug Targets
    Receptor Tyrosine Kinases (RTKs)
    Receptor Tyrosine Kinases (RTKs) in the Akt Pathway
    Negative Regulators of the Jak/STAT Pathway
    Receptors in the Jak/STAT Pathway
    EGF Receptor

    References

    • Nevoltris, D; Lombard, B; et al. Conformational Nanobodies Reveal Tethered Epidermal Growth Factor Receptor Involved in EGFR/ErbB2 Predimers. ACS NANO 9:1388-1399(2015).
    • D'Souza, JW; Reddy, S; et al. Combining Anti-ERBB3 Antibodies Specific for Domain I and Domain III Enhances the Anti-Tumor Activity over the Individual Monoclonal Antibodies. PLOS ONE 9:-(2014).

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