Active Recombinant Human ERBB4 Protein, hIgG/His-tagged
Cat.No. : | ERBB4-04H |
Product Overview : | Recombinant human ErbB4 (26-649aa), fused to hIgG-His-tag at C-terminus, was expressed in HEK293 and purified by using conventional chromatography techniques. |
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Species : | Human |
Source : | HEK293 |
Tag : | Fc&His |
Protein Length : | 26-649 a.a. |
Description : | This gene is a member of the Tyr protein kinase family and the epidermal growth factor receptor subfamily. It encodes a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins and other factors and induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. Mutations in this gene have been associated with cancer. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. |
Form : | Liquid |
Bio-activity : | Measured by its binding ability in a functional ELISA with Human NRG1/HRG1. The ED50 range ≤ 0.2 μg/mL. |
Molecular Mass : | 96.6 kDa (863aa) |
AA Sequence : | QSVCAGTENKLSSLSDLEQQYRALRKYYENCEVVMGNLEITSIEHNRDLSFLRSVREVTGYVLVALNQFRYLPLENLRIIRGTKLYEDRYALAIFLNYRKDGNFGLQELGLKNLTEILNGGVYVDQNKFLCYADTIHWQDIVRNPWPSNLTLVSTNGSSGCGRCHKSCTGRCWGPTENHCQTLTRTVCAEQCDGRCYGPYVSDCCHRECAGGCSGPKDTDCFACMNFNDSGACVTQCPQTFVYNPTTFQLEHNFNAKYTYGAFCVKKCPHNFVVDSSSCVRACPSSKMEVEENGIKMCKPCTDICPKACDGIGTGSLMSAQTVDSSNIDKFINCTKINGNLIFLVTGIHGDPYNAIEAIDPEKLNVFRTVREITGFLNIQSWPPNMTDFSVFSNLVTIGGRVLYSGLSLLILKQQGITSLQFQSLKEISAGNIYITDNSNLCYYHTINWTTLFSTINQRIVIRDNRKAENCTAEGMVCNHLCSSDGCWGPGPDQCLSCRRFSRGRICIESCNLYDGEFREFENGSICVECDPQCEKMEDGLLTCHGPGPDNCTKCSHFKDGPNCVEKCPDGLQGANSFIFKYADPDRECHPCHPNCTQGCNGPTSHDCIYYPWTGHSTLPQHAR |
Endotoxin : | < 1 EU/μg of protein (determined by LAL method) |
Purity : | > 90% by SDS-PAGE |
Applications : | SDS-PAGE, Bioactivity |
Storage : | Can be stored at +2 to +8 centigrade for 1 week. For long term storage, aliquot and store at -20 to -80 centigrade. Avoid repeated freezing and thawing cycles. |
Concentration : | 0.25 mg/mL (determined by Absorbance at 280nm) |
Storage Buffer : | Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol |
Gene Name | ERBB4 erb-b2 receptor tyrosine kinase 4 [ Homo sapiens (human) ] |
Official Symbol | ERBB4 |
Synonyms | ERBB4; erb-b2 receptor tyrosine kinase 4; HER4; ALS19; p180erbB4; receptor tyrosine-protein kinase erbB-4; avian erythroblastic leukemia viral (v-erb-b2) oncogene homolog 4; human epidermal growth factor receptor 4; proto-oncogene-like protein c-ErbB-4; tyrosine kinase-type cell surface receptor HER4; v-erb-a erythroblastic leukemia viral oncogene homolog 4; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 4; EC 2.7.10.1 |
Gene ID | 2066 |
mRNA Refseq | NM_005235 |
Protein Refseq | NP_005226 |
MIM | 600543 |
UniProt ID | Q15303 |
◆ Recombinant Proteins | ||
Erbb4-7416M | Active Recombinant Mouse Erbb4 Protein, His tagged | +Inquiry |
ERBB4-216HAF555 | Recombinant Human ERBB4 Protein, His-tagged, Alexa Fluor 555 conjugated | +Inquiry |
ERBB4-288HAF555 | Recombinant Human ERBB4 Protein, Fc/His-tagged, Alexa Fluor 555 conjugated | +Inquiry |
ERBB4-358H | Recombinant Human ERBB4 protein, Fc-tagged | +Inquiry |
Erbb4-473M | Active Recombinant Mouse V-Erb-A Erythroblastic Leukemia Viral Oncogene Homolog 4 (avian) | +Inquiry |
◆ Cell & Tissue Lysates | ||
ERBB4-1543HCL | Recombinant Human ERBB4 cell lysate | +Inquiry |
ERBB4-1417MCL | Recombinant Mouse ERBB4 cell lysate | +Inquiry |
ERBB4-895RCL | Recombinant Rat ERBB4 cell lysate | +Inquiry |
ERBB4-001HCL | Recombinant Human ERBB4 cell lysate | +Inquiry |
Not For Human Consumption!
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