Recombinant Human V-Erb-A Erythroblastic Leukemia Viral Oncogene Homolog 4 (avian), GST-tagged

• Cat.No.: ERBB4-1126H
• Product Overview: Recombinant human ERBB4 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Specification

• Species: Human
• Source: Sf9 Cells
• Tag: GST
• Description: ERBB4 is a receptor tyrosine kinase that is a member of the epidermal growth factor receptor subfamily. ERBB4 is a single-pass type I transmembrane protein with multiple furin-like cysteine rich domains, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins-2 and -3, heparin-binding EGF-like growth factor and betacellulin.
• Biological Activity: 137 pmol/µg×min
• Molecular Weight: 102,062 Da
• Appearance: Liquid
• Storage: 50 mMTris-HCl, pH 8.0;100 mMNaCl, 5 mM DTT, 15 mM reducedglutathione, 20% glycerol.
• Pathways: Calcium signaling pathway; Endocytosis; ErbB signaling pathway

Gene Information

• Gene Name: ERBB4 v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) [ Homo sapiens ]
• Official Symbol: ERBB4
• Synonyms: ERBB4; v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian); v-erb-a avian erythroblastic leukemia viral oncogene homolog-like 4; Receptor tyrosine-protein kinase erbB-4; HER4; Tyrosine kinase-type cell surface receptor HER4; p180erbB4; EC 2.7.10.1; MGC138404; avian erythroblastic leukemia viral (v-erb-b2) oncogene homolog 4; receptor tyrosine-protein kinase erbB-4; v-erb-a erythroblastic leukemia viral oncogene homolog 4; OTTHUMP00000163968; OTTHUMP00000206623; OTTHUMP00000209432
• Gene ID: 2066
• mRNA Refseq: NM_001042599
• Protein Refseq: NP_001036064
• MIM: 600543
• UniProt ID: Q15303
• Chromosome Location: 2q33.3-q34
• Function: ATP binding; nucleotide binding; protein binding; receptor activity; receptor signaling protein tyrosine kinase activity; transferase activity; transmembrane receptor protein tyrosine kinase activity