Recombinant Human HIF1AN Protein (Ala2-Asn349), His tagged

Description :	Hydroxylates HIF-1 alpha at' Asn-803' in the C-terminal transactivation domain (CAD). Functions as an oxygen sensor and, under normoxic conditions, the hydroxylation prevents interaction of HIF-1 with transcriptional coactivators including Cbp/p300-interacting transactivator. Involved in transcriptional repression through interaction with HIF1A, VHL and histone deacetylases. Hydroxylates specific Asn residues within ankyrin repeat domains (ARD) of NFKB1, NFKBIA, NOTCH1, ASB4, PPP1R12A and several other ARD-containing proteins. Also hydroxylates Asp and His residues within ARDs of ANK1 and TNKS2, respectively. Negatively regulates NOTCH1 activity, accelerating myogenic differentiation. Positively regulates ASB4 activity, promoting vascular differentiation.
Source :	E. coli
Species :	Human
Tag :	His
Molecular Mass :	40.23 kDa
Protein length :	Ala2-Asn349
Purity :	>90 % as determined by SDS-PAGE.
Notes :	For research use only.
Storage :	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8 centigrade for one week. Store at -20 to -80 centigrade for twelve months from the date of receipt.
Storage Buffer :	Supplied as solution form in PBS pH 7.5 or lyophilized from PBS pH 7.5.
Reconstitution :	Reconstitute in sterile water for a stock solution.
Shipping :	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.

Gene Name	HIF1AN hypoxia inducible factor 1, alpha subunit inhibitor [ Homo sapiens (human) ]
Official Symbol	HIF1AN
Synonyms	HIF1AN; hypoxia inducible factor 1, alpha subunit inhibitor; hypoxia-inducible factor 1-alpha inhibitor; DKFZp762F1811; FIH1; FLJ20615; FLJ22027; Peptide aspartate beta dioxygenase; FIH-1; factor inhibiting HIF1; factor inhibiting HIF-1; peptide-aspartate beta-dioxygenase; hypoxia-inducible factor asparagine hydroxylase;
Gene ID	55662
mRNA Refseq	NM_017902
Protein Refseq	NP_060372
MIM	606615
UniProt ID	Q9NWT6