HIF1AN
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Official Full Name
hypoxia inducible factor 1, alpha subunit inhibitor -
Overview
Hypoxia-inducible factor 1-alpha inhibitor is a protein that in humans is encoded by the HIF1AN gene. -
Synonyms
HIF1AN;hypoxia inducible factor 1, alpha subunit inhibitor;hypoxia-inducible factor 1-alpha inhibitor;DKFZp762F1811;FIH1;FLJ20615;FLJ22027;Peptide aspartate beta dioxygenase;FIH-1;factor inhibiting HIF1;factor inhibiting HIF-1;peptide-aspartate
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- E.coli
- Mammalian Cells
- HEK293
- Wheat Germ
- Human
- Yeast
- In Vitro Cell Free System
- His
- DDK
- Myc
- Non
- GST
- Avi
- Fc
- Flag
Involved Pathway
HIF1AN involved in several pathways and played different roles in them. We selected most pathways HIF1AN participated on our site, such as Cellular response to hypoxia,Cellular responses to stress,HIF-2-alpha transcription factor network, which may be useful for your reference. Also, other proteins which involved in the same pathway with HIF1AN were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Hypoxic and oxygen homeostasis regulation of HIF-1-alpha | COPS5,NAA10,HIF3A,GNB2L1 |
| Cellular response to hypoxia | EGLN1B,EGLN2,EGLN3,HIF3A,EPAS1B,HIF1AL |
| HIF-2-alpha transcription factor network | EGLN2,CITED2,EGLN3 |
| Regulation of Hypoxia-inducible Factor (HIF) by oxygen | HIF3A,EGLN2,EGLN1B,EPAS1B,EGLN3,HIF1AL |
| Oxygen-dependent asparagine hydroxylation of Hypoxia-inducible Factor Alpha | EPAS1B |
| Cellular responses to stress | PHC1,H3F3D,SCMH1,KAT5,HSPH1,ATG7,HIST1H1D,DYNLL2B,Txn1,CDKN2C |
Protein Function
HIF1AN has several biochemical functions, for example, NF-kappaB binding,Notch binding,ankyrin repeat binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HIF1AN itself. We selected most functions HIF1AN had, and list some proteins which have the same functions with HIF1AN. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| iron ion binding | CYP27B1,CYP26C1,CYP2A13,CYP3A25,HBB,MFI2,CYP4F11,CYP2X10.2,CYP2AA8,CYP20A1 |
| NF-kappaB binding | CDK5RAP3,DNAJA3,MTDH,TAF4B,HSPA6,HDAC3,GSK3B,CDKN2A,BRMS1,CPNE1 |
| Notch binding | DTX1,C8orf4,JAG1A,NCOR2,DLL4,AAK1,JAG1B,DLL1,EGFL7,SNW1 |
| zinc ion binding | GLO1,ZCCHC17,RNF115,TXNDC17,TRIM44,CCNB1IP1,KDM5A,TRIM12A,ZNF622,L3MBTL4 |
| carboxylic acid binding | AKR1C2,AKR1C21,PCK1,GOT1,GRHPR,HMGCL |
| protein homodimerization activity | RELA,XCL1,RAB11FIP4B,MSH2,EEA1,S100A13,SOD1,RAB11FIP2,PFKM,IMPA2 |
| oxygen sensor activity | EGLN2,NOX4 |
| oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors | KDM5A,ALKBH8,KDM5C,KDM5D,KDM5B,KDM5BA,JHDM1D,EGLN2,EGLN3,PHF8 |
| protein binding | KDM4A,SDPR,NCOA5,SR140,NAV2,CCDC36,NMUR2,ARVCF,SIGLEC6,PPP1R12A |
Interacting Protein
HIF1AN has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HIF1AN here. Most of them are supplied by our site. Hope this information will be useful for your research of HIF1AN.
ASB9;HIF1A;TNKS2;TNKS;GABPB2;TRPV4;OTUD7B;ASB13;INVS
Resources
Research Area
Regulator of NFkBNotch Family
Intracellular Factors in Inflammation
ROS and Stress Resistance
Intracellular Signaling Molecules in Angiogenesis
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References
- Liu, Y; Zhang, LW; et al. DNA-PKcs Deficiency Inhibits Glioblastoma Cell-Derived Angiogenesis After Ionizing Radiation. JOURNAL OF CELLULAR PHYSIOLOGY 230:1094-1103(2015).
- Shida, T; Nozawa, T; et al. Fluvastatin-induced reduction of oxidative stress ameliorates diabetic cardiomyopathy in association with improving coronary microvasculature. HEART AND VESSELS 29:532-541(2014).
