Recombinant Human DST

• Cat.No.: DST-26933TH
• Product Overview: Recombinant fragment of Human Dystonin with N-terminal proprietary tag. Predicted MW 36.63 kDa.

Specification

• Description: This gene encodes a member of the plakin protein family of adhesion junction plaque proteins. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene, but the full-length nature of some variants has not been defined. It has been reported that some isoforms are expressed in neural and muscle tissue, anchoring neural intermediate filaments to the actin cytoskeleton, and some isoforms are expressed in epithelial tissue, anchoring keratin-containing intermediate filaments to hemidesmosomes. Consistent with the expression, mice defective for this gene show skin blistering and neurodegeneration.
• Protein length: 100 amino acids
• Molecular Weight: 36.630kDa inclusive of tags
• Source: Wheat germ
• Form: Liquid
• Purity: Proprietary Purification
• Storage buffer: pH: 8.00Constituents:0.3% Glutathione, 0.79% Tris HCl
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequences of amino acids: EDKLILAGNALQSDSKRLESGVQFQ NEAEIAGYILECENLLRQHVIDVQI LIDGKYYQADQLVQRVAKLRDEIMA LRNECSSVYSKGRILTTEQTKLMIS
• Tag: Non

Gene Information

• Gene Name: DST dystonin [ Homo sapiens ]
• Official Symbol: DST
• Synonyms: DST; dystonin; BPAG1, bullous pemphigoid antigen 1, 230/240kDa; bullous pemphigoid antigen 1; BP240; BPA; CATX 15; FLJ13425; FLJ21489; FLJ30627; FLJ32235; KIAA0728; MACF2
• Gene ID: 667
• mRNA Refseq: NM_001723
• Protein Refseq: NP_001714
• MIM: 113810
• Uniprot ID: Q03001
• Chromosome Location: 6p12.1
• Pathway: Alpha6-Beta4 Integrin Signaling Pathway, organism-specific biosystem; Cell junction organization, organism-specific biosystem; Cell-Cell communication, organism-specific biosystem; Type I hemidesmosome assembly, organism-specific biosystem
• Function: actin binding; calcium ion binding; integrin binding; microtubule plus-end binding; protein C-terminus binding