Recombinant Human DST Protein (1-195 aa), His-tagged

• Cat.No.: DST-1693H
• Product Overview: Recombinant Human DST Protein (1-195 aa) is produced by Yeast expression system. This protein is fused with a 6xHis tag at the N-terminal. Research Area: Signal Transduction. Protein Description: Partial.

Specification

• Description: Cytoskeletal linker protein. Acts as an integrator of intermediate filaments, actin and microtubule cytoskeleton networks. Required for anchoring either intermediate filaments to the actin cytoskeleton in neural and muscle cells or keratin-containing intermediate filaments to hidesmosomes in epithelial cells. The proteins may self-aggregate to form filaments or a two-dimensional mesh.Isoform 3: plays a structural role in the assbly of hidesmosomes of epithelial cells; anchors keratin-containing intermediate filaments to the inner plaque of hidesmosomes. Required for the regulation of keratinocyte polarity and motility; mediates integrin ITGB4 regulation of RAC1 activity.Isoform 6: required for bundling actin filaments around the nucleus.Isoform 7: regulates the organization and stability of the microtubule network of sensory neurons to allow axonal transport.
• Source: Yeast
• Species: Human
• Tag: His
• Form: Tris-based buffer,50% glycerol
• Molecular Mass: 23.7 kDa
• Protein length: 1-195 aa
• AA Sequence: MHSSSYSYRSSDSVFSNTTSTRTSL DSNENLLLVHCGPTLINSCISFGSE SFDGHRLEMLQQIANRVQRDSVICE DKLILAGNALQSDSKRLESGVQFQN EAEIAGYILECENLLRQHVIDVQIL IDGKYYQADQLVQRVAKLRDEIMAL RNECSSVYSKGRILTTEQTKLMISG ITQSLNSGFAQTLHPSLTSG
• Purity: > 90% as determined by SDS-PAGE.
• Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4 centigrade for up to one week.
• Storage: The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20 centigrade/-80 centigrade. The shelf life of lyophilized form is 12 months at -20 centigrade/-80 centigrade.
• Concentration: A hardcopy of COA with reconstitution instruction is sent along with the products.

Gene Information

• Gene Name: DST dystonin [ Homo sapiens ]
• Official Symbol: DST
• Synonyms: DST; dystonin; BP240; BPA; CATX 15; FLJ13425; FLJ21489; FLJ30627; FLJ32235; KIAA0728; MACF2; DT; DMH; BPAG1; CATX15; CATX-15; D6S1101; FLJ46791; KIAA0465; KIAA1470; DKFZp564B2416
• Gene ID: 667
• mRNA Refseq: NM_001723
• Protein Refseq: NP_001714
• MIM: 113810
• UniProt ID: Q03001