DST
-
Official Full Name
dystonin -
Overview
This gene encodes a member of the plakin protein family of adhesion junction plaque proteins. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene, but the full-length nature of some variants has not been defined. It has been reported that some isoforms are expressed in neural and muscle tissue, anchoring neural intermediate filaments to the actin cytoskeleton, and some isoforms are expressed in epithelial tissue, anchoring keratin-containing intermediate filaments to hemidesmosomes. Consistent with the expression, mice defective for this gene show skin blistering and neurodegeneration. -
Synonyms
DST;dystonin;BPAG1, bullous pemphigoid antigen 1, 230/240kDa;bullous pemphigoid antigen 1;BP240;BPA;CATX 15;FLJ13425;FLJ21489;FLJ30627;FLJ32235;KIAA0728;MACF2;230 kDa bullous pemphigoid antigen;230/240 kDa bullous pemphigoid antigen;BP230;BPAG1;Bullous pemphigoid antigen;DMH;DT;Dystonia musculorum protein;Hemidesmosomal plaque protein;trabeculin-beta;OTTHUMP00000016653;OTTHUMP00000016654;OTTHUMP00000016655;OTTHUMP00000016657;OTTHUMP00000016658;OTTHUMP00000224445;CATX15;CATX-15;D6S1101
Recombinant Proteins
- Human
- E.coli
- Mammalian Cell
- Wheat Germ
- Yeast
- HEK293
- His&SUMO
- His
- Non
- GST
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| DST-1196H | Recombinant Human DST Protein, His-SUMO-tagged | E.coli | Human | His&SUMO | 1-195 a.a. |
|
| DST-156H | Recombinant Human DST | Mammalian Cell | Human | His |
|
|
| DST-26933TH | Recombinant Human DST | Wheat Germ | Human | Non | 100 amino acids |
|
| DST-2893H | Recombinant Human DST Protein, GST-tagged | Wheat Germ | Human | GST |
|
|
| DST-1693H | Recombinant Human DST Protein (1-195 aa), His-tagged | Yeast | Human | His | 1-195 aa |
|
| DST-2208H | Recombinant Human DST Protein (Met1-Trp979), N-His tagged | E.coli | Human | His | Met1-Trp979 |
|
| DST-2823H | Recombinant Human DST protein(6011-6580 aa), C-His-tagged | E.coli | Human | His | 6011-6580 aa |
|
| DST-2823H-B | Recombinant Human DST Protein Pre-coupled Magnetic Beads | HEK293 | Human |
|
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| DST-301443H | Recombinant Human DST protein, GST-tagged | E.coli | Human | GST | Ser420-Asp610 |
|
| DST-688H | Recombinant Human DST Protein, His-tagged | E.coli | Human | His | Met1~Thr252 |
|
Involved Pathway
DST involved in several pathways and played different roles in them. We selected most pathways DST participated on our site, such as Alpha6-Beta4 Integrin Signaling Pathway,Assembly of collagen fibrils and other multimeric structures,Cell junction organization, which may be useful for your reference. Also, other proteins which involved in the same pathway with DST were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Extracellular matrix organization | COL28A1D,EFEMP1,CRTAP,ADAM8,COMP,NID1,MMP8,LTBP4,ADAMTS5,ADAMTS2 |
| Collagen formation | LEPREL2,COL8A1,CTSB,COL8A2,P3H2,COL6A3,CTSS,COL15A1B,COL4A5,COL4A6 |
| Cell junction organization | CDH10A,CDH17,CDH18A,CLDN3,CLDN20,CDH5,CADM2,TESK1,CLDN23,CADM2A |
| Alpha6-Beta4 Integrin Signaling Pathway | EIF4EB,DSP,MST1R,EGFR,CDKN1A,SMAD3B,PLEC,EIF4E,CLCA1,EIF4EBP1 |
| Cell-Cell communication | CDH9,KIRREL3,KIRRELA,CDH2,CDH24,CDH10A,CDH18A,CDH7,CTNND1,INADL |
| Assembly of collagen fibrils and other multimeric structures | LOX,MMP20,COL1A1,COL6A3,COL4A6,CD151,COL6A1,BMP1B,LOXL2,TLL2 |
| Type I hemidesmosome assembly | PLECA,COL17A1A,CD151 |
Protein Function
DST has several biochemical functions, for example, actin binding,calcium ion binding,integrin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DST itself. We selected most functions DST had, and list some proteins which have the same functions with DST. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein C-terminus binding | TOP2B,DDX1,PEX16,VGLL2,CEP135,PEX1,STIP1,BCL10,TAF13,SDCBP |
| integrin binding | WISP1B,FCER2,ICAM1,SFRP2,WISP1A,NISCH,THBS4,MMP14,TSPAN8,CD9 |
| actin binding | MYO19,EPB41L2,EPS8L1,HOOK1,HIP1R,KPTN,MYH7B,ANTXR2A,SHANK3,MYHZ1.1 |
| calcium ion binding | C2CD4B,MYL9B,ANXA2A,MYL9A,PCDH2AB11,CAPN8,ANXA1B,AKR1C1,C1R,PCDHGA2 |
| microtubule plus-end binding | CLIP2,KIF18A,CLASP1A,CLASP1,APC,MAPRE1,STIM1,CLIP1,KIF2C |
| protein binding | INSIG1,DNM2,TRMT12,POLR1C,FMNL1,MAGEA2B,CELF1,TFB1M,SH2D3A,CATSPERB |
| protein homodimerization activity | PON3,RCHY1,MSH2,TESCA,SUMF1,ADH5,DGCR8,PDE2A,HER5,TREX2 |
Interacting Protein
DST has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DST here. Most of them are supplied by our site. Hope this information will be useful for your research of DST.
Mapre1;MAPRE1;OPTN;APPL1;AKR1B1;NFKB1;CBFB;RNPS1;PUF60;SMAD9;TULP3
Resources
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References
- Kalache, S; Lakhani, P; et al. Effects of Preexisting Autoimmunity on Heart Graft Prolongation After Donor-Specific Transfusion and Anti-CD154. TRANSPLANTATION 97:12-19(2014).
- Wang, YT; Wang, H; et al. Rapid Dendritic Cell Activation and Resistance to Allotolerance Induction in Anti-CD154-Treated Mice Receiving CD47-Deficient Donor-Specific Transfusion. CELL TRANSPLANTATION 23:355-363(2014).
