Recombinant Human DDX6 protein, GST-tagged

• Cat.No.: DDX6-28328TH
• Product Overview: Recombinant Human DDX6(1 a.a. - 483 a.a.) fused with GST tag at N-terminal was expressed in Wheat Germ.

Specification

• Description: This gene encodes a member of the DEAD box protein family. The protein is an RNA helicase found in P-bodies and stress granules, and functions in translation suppression and mRNA degradation. It is required for microRNA-induced gene silencing. Multiple alternatively spliced variants, encoding the same protein, have been identified.
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Form: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
• Molecular Mass: 78.87 kDa
• AA Sequence: MSTARTENPVIMGLSSQNGQLRGPV KPTGGPGGGGTQTQQQMNQLKNTNT INNGTQQQAQSMTTTIKPGDDWKKT LKLPPKDLRIKTSDVTSTKGNEFED YCLKRELLMGIFEMGWEKPSPIQEE SIPIALSGRDILARAKNGTGKSGAY LIPLLERLDLKKDNIQAMVIVPTRE LALQVSQICIQVSKHMGGAKVMATT GGTNLRDDIMRLDDTVHVVIATPGR ILDLIKKGVAKVDHVQMIVLDEADK LLSQDFVQIMEDIILTLPKNRQILL YSATFPLSVQKFMNSHLQKPYEINL MEELTLKGVTQYYAYVTERQKVHCL NTLFSRLQINQSIIFCNSSQRVELL AKKISQLGYSCFYIHAKMRQEHRNR VFHDFRNGLCRNLVCTDLFTRGIDI QAVNVVINFDFPKLAETYLHRIGRS GRFGHLGLAINLITYDDRFNLKSIE EQLGTEIKPIPSNIDKSLYVAEYHS EPVEDEKP
• Applications: Enzyme-linked Immunoabsorbent Assay; Western Blot (Recombinant protein); Antibody Production; Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Protein length: 1-483

Gene Information

• Gene Name: DDX6 DEAD (Asp-Glu-Ala-Asp) box helicase 6 [ Homo sapiens ]
• Official Symbol: DDX6
• Synonyms: DDX6; DEAD (Asp-Glu-Ala-Asp) box helicase 6; DEAD (Asp Glu Ala Asp) box polypeptide 6 , DEAD/H (Asp Glu Ala Asp/His) box polypeptide 6 (RNA helicase, 54kD) , HLR2; probable ATP-dependent RNA helicase DDX6; RCK; DEAD box-6; oncogene RCK; DEAD box protein 6; ATP-dependent RNA helicase p54; DEAD (Asp-Glu-Ala-Asp) box polypeptide 6; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 6 (RNA helicase, 54kD); P54; HLR2; FLJ36338
• Gene ID: 1656
• mRNA Refseq: NM_001257191
• Protein Refseq: NP_001244120
• MIM: 600326
• UniProt ID: P26196
• Chromosome Location: 11q23.3
• Pathway: Deadenylation-dependent mRNA decay, organism-specific biosystem; Decapping complex, organism-specific biosystem; Decapping complex, conserved biosystem; Gene Expression, organism-specific biosystem; RNA degradation, organism-specific biosystem; RNA degradation, conserved biosystem; mRNA Decay by 5 to 3 Exoribonuclease, organism-specific biosystem

Reviews

01/25/2023

Whether it's troubleshooting experimental issues, providing guidance on experimental design, or answering any inquiries related to the DDX6 protein, the manufacturer is committed to helping researchers overcome challenges and achieve their scientific goals.

09/09/2019

The manufacturer also values customer satisfaction and strives to maintain a strong relationship with researchers.

01/13/2016

They actively seek feedback and incorporate it into their product development process, continuously improving the quality and performance of the DDX6 protein.

Q&As

Can targeting DDX6 be a therapeutic strategy for cancer treatment?

There is emerging interest in developing therapies that target DDX6 to modulate its activity, potentially impacting cancer cell growth.

Does DDX6 have a role in antiviral defense mechanisms?

Yes, DDX6 has been implicated in antiviral responses, influencing the replication of certain viruses.

How does DDX6 influence RNA granules in cells?

DDX6 is a component of RNA granules and is involved in their assembly, influencing mRNA storage and translation repression.

How is DDX6 implicated in cancer?

DDX6 dysregulation has been observed in various cancers, suggesting its involvement in tumorigenesis and progression.

Are there clinical trials exploring DDX6 as a therapeutic target?

Some preclinical studies suggest the therapeutic potential of targeting DDX6, but clinical trials are still in the early stages.