DDX58
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Official Full Name
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 -
Overview
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases which are implicated in a number of cellular processes involving RNA binding and alteration of RNA secondary structure. This gene encodes a protein containing RNA helicase-DEAD box protein motifs and a caspase recruitment domain (CARD). It is involved in viral double-stranded (ds) RNA recognition and the regulation of immune response. [provided by RefSeq, Jul 2008] -
Synonyms
DDX58;DEAD (Asp-Glu-Ala-Asp) box polypeptide 58;RIGI;RIG-I;RLR-1;probable ATP-dependent RNA helicase DDX58;RIG-1;RNA helicase RIG-I;DEAD box protein 58;RIG-I-like receptor 1;retinoic acid inducible gene I;retinoic acid-inducible gene 1 protein;retinoic acid-inducible gene I protein;DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide
Recombinant Proteins
- Human
- Rhesus macaque
- Mouse
- E. coli
- Wheat Germ
- HEK293
- Mammalian Cell
- E.coli
- Mamanlian cells
- HEK293T
- In Vitro Cell Free System
- His
- GST
- Myc&DDK
- Non
- His&Fc&Avi
- Flag
Involved Pathway
DDX58 involved in several pathways and played different roles in them. We selected most pathways DDX58 participated on our site, such as NF-kappa B signaling pathway,RIG-I-like receptor signaling pathway,Cytosolic DNA-sensing pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with DDX58 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Hepatitis B | STAT4,Ifna15,PIK3R5,TBK1,MAP3K1,IFN-a,IFNA13,BCL2,TP53,YWHAZ |
| NF-kappa B signaling pathway | BCL2,TICAM2,TRIM25,CFLAR,TNFRSF13C,GADD45B,CCL4L1,RELA,LRDD,IRAK1 |
| Epstein-Barr virus infection | YWHAE,SND1,CSNK2B,PIK3CA,HSPA6,POLR3E,MAPK9,CD19,HSPB2,PSMC1 |
| Hepatitis C | HRAS,LDLR,TRADD,TRAF2,PIK3CD,PPP2R1B,IFN-a,CLDN8,PPP2R2D,BAD |
| Cytosolic DNA-sensing pathway | LOC100033925,IFNB,NFKBIAA,IRF7,IKBKB,IFNA8,MAVS,RIPK1L,OSTN,POLR3GL |
| Influenza A | NXF2,PIK3R3,ADAR,MAP2K6,CCL2,NLRX1,CXCL10,HLA-DPA1,PIK3R2,NXT1 |
| Measles | EIF2AK3,IL13,IL2RG,CD209C,HSPA8,TNFRSF10B,IFNA16,Ifna11,CD3E; CD3D,MAVS |
| RIG-I-like receptor signaling pathway | IL-8,MAPK9,IFNA4,MAP3K7,IFIH1,RNF125,IFNE,SIKE1,MAPK8A,DAK |
| Herpes simplex infection | SRSF5B,TNFSF14,TBPL1,TAF3,HLA-DQA1,LTA,TRAF1,HNRPKL,MAP3K7,EIF2AK2 |
Protein Function
DDX58 has several biochemical functions, for example, ATP binding,double-stranded DNA binding,double-stranded RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DDX58 itself. We selected most functions DDX58 had, and list some proteins which have the same functions with DDX58. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | RASD1,CLIC5,ASIC1,DNAJC28,CD2,NEIL2,PARVA,HSPA8,PIFO,MAP3K11 |
| double-stranded RNA binding | ACTN1,SUPV3L1,DHX15,ILF3,ZNF346,DGCR8,OASL2,CLTC,IFIH1,MYH4 |
| ATP binding | BCKDK,ACSS3,ABCD3B,FARSA,NARS,ITM2C,PRKCDA,ATP2B1A,UBE2G2,MYO18A |
| double-stranded DNA binding | MTERFD3,ERCC5,HNRNPDL,EGFR,DDX11,APTX,AIM2,XRCC6,PRKDC,XRCC5 |
| helicase activity | GTF2F2,DDX39,CHD1L,DHX36,CHD8,WRN,CHD9,DDX19,DQX1,HELLS |
| single-stranded RNA binding | JMJD6,POLR2GL,TLR7,LSM14A,HNRNPA1,A1CF,AGO1,AGO2,NXF1,EIF2C3 |
| zinc ion binding | CPB1,MMP15,ZNF184,ZNRF4,BMI1,BRF1A,TRAF4,MARCH7,ABLIM2,TRIM35-31 |
| identical protein binding | SIAH1,ADORA2A,BIN1,SDK2,CLDN23,SLC2A1,RASSF1,FGFR1,TK1,TPCN1 |
Interacting Protein
DDX58 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DDX58 here. Most of them are supplied by our site. Hope this information will be useful for your research of DDX58.
MAVS;ZC3HAV1;TRIM25
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References
- Ovsyannikova, IG; Salk, HM; et al. Single-nucleotide polymorphism associations in common with immune responses to measles and rubella vaccines. IMMUNOGENETICS 66:663-669(2014).
- Enevold, C; Kjaer, L; et al. Genetic polymorphisms of dsRNA ligating pattern recognition receptors TLR3, MDA5, and RIG-I. Association with systemic lupus erythematosus and clinical phenotypes. RHEUMATOLOGY INTERNATIONAL 34:1401-1408(2014).
