DDX50
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Official Full Name
DEAD (Asp-Glu-Ala-Asp) box polypeptide 50 -
Overview
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box enzyme that may be involved in ribosomal RNA synthesis or processing. This gene and DDX21, also called RH-II/GuA, have similar genomic structures and are in tandem orientation on chromosome 10, suggesting that the two genes arose by gene duplication in evolution. This gene has pseudogenes on chromosomes 2, 3 and 4. Alternative splicing of this gene generates multiple transcript variants, but the full length nature of all the other variants but one has not been defined. -
Synonyms
DDX50;DEAD (Asp-Glu-Ala-Asp) box polypeptide 50;ATP-dependent RNA helicase DDX50;GU2;GUB;MGC3199;RH II/GuB;4933429B04Rik;DDX50_HUMAN;DEAD box protein 50;Gu beta;Gu-beta;MGC109605;Nucleolar protein Gu2;RH II;RNA helicase II / Gu beta;RNA helicase II/Gu beta;RH-II/GuB
Recombinant Proteins
- Rhesus macaque
- Human
- Mouse
- Mammalian Cells
- Wheat Germ
- E.coli
- HEK293
- In Vitro Cell Free System
- His
- GST
- Myc&DDK
- Non
- His&Fc&Avi
Involved Pathway
DDX50 involved in several pathways and played different roles in them. We selected most pathways DDX50 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with DDX50 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
DDX50 has several biochemical functions, for example, ATP binding,ATP-dependent RNA helicase activity,poly(A) RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DDX50 itself. We selected most functions DDX50 had, and list some proteins which have the same functions with DDX50. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP-dependent RNA helicase activity | DDX51,DDX6,DDX3,DDX19,EIF4A1B,BAT1,DDX47,DHX32,YTHDC2,EIF4A3 |
| poly(A) RNA binding | RPS15,SMC1A,EPPK1,NCOA5,CFAP20,RPL22,EIF3G,MRPL2,ANXA11,DHX37 |
| ATP binding | AK7,TRNT1,ABCA8,EPHA2,CASKB,HIPK4,ACLYA,NMNAT2,OBSCN,TRMU |
Interacting Protein
DDX50 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DDX50 here. Most of them are supplied by our site. Hope this information will be useful for your research of DDX50.
ESR2;SMNDC1;PINX1;KRAS;q81xs6_bacan;MED19;ssrna_ug;AIM2;MED26;ESR1;NPM1;RPL10;MNDA;HDGF;SRPK2;HNRNPU
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