TNFSF13
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Official Full Name
tumor necrosis factor (ligand) superfamily, member 13 -
Overview
The protein encoded by this gene is a member of the tumor necrosis factor (TNF) ligand family. This protein is a ligand for TNFRSF17/BCMA, a member of the TNF receptor family. This protein and its receptor are both found to be important for B cell development. In vitro experiments suggested that this protein may be able to induce apoptosis through its interaction with other TNF receptor family proteins such as TNFRSF6/FAS and TNFRSF14/HVEM. Alternative splicing results in multiple transcript variants. Some transcripts that skip the last exon of the upstream gene (TNFSF12) and continue into the second exon of this gene have been identified; such read-through transcripts are contained in GeneID 407977, TNFSF12-TNFSF13. -
Synonyms
TNFSF13;tumor necrosis factor (ligand) superfamily, member 13;tumor necrosis factor ligand superfamily member 13;APRIL;CD256;a proliferation-inducing ligand;tumor necrosis factor-like protein ZTNF2;tumor necrosis factor-related death ligand-1;TNF-
Recombinant Proteins
- Human
- Mouse
- Cynomolgus
- Rhesus macaque
- Rat
- Cattle
- Dog
- Zebrafish
- Rabbit
- HEK293
- Mammalian cells
- E.coli
- Human
- CHO
- N-His-Avi,N-Flag
- C-hFc
- Hi-5 Insect Cell
- Yeast
- Mammalian Cell
- Human Cell
- Human Cells
- HA
- Non
- Flag
- His&Flag
- N-His-Flag
- His&T7
- His
- Fc
- T7
- His&GST
- Fc&Avi
- His&Fc&Avi
- N-His-Avi,N-Flag
- His&FLAG&Avi
Involved Pathway
TNFSF13 involved in several pathways and played different roles in them. We selected most pathways TNFSF13 participated on our site, such as Cytokine-cytokine receptor interaction,Intestinal i,ne network for IgA production, which may be useful for your reference. Also, other proteins which involved in the same pathway with TNFSF13 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Intestinal i | H2-AB1,MHC2DEB,AICDA,MHC2DCB,CCL25B,ITGB7,MAP3K14,IL6,CXCL12B,CXCL12 |
| Cytokine-cytokine receptor interaction | Ccl21c,TNFRSF10B,IFNA2,GM-CSF,TNFRSF11A,ACVR1BA,IL28A,EPO,PRLRA,IL1R2 |
| Rheumatoid arthritis | GM-CSF,CXCL1,IL1A,ATP6V1D,TLR2,H2-AB1,IL11,TLR4,HLA-DRA,CD86 |
| ne network for IgA production | IL-15RA,LTBR,HLA-DQB1,CD40,CXCL12B,Il2,H2-AB1,BLB1,HLA-DOB,CXCR4B |
Protein Function
TNFSF13 has several biochemical functions, for example, cytokine activity,receptor binding,tumor necrosis factor receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TNFSF13 itself. We selected most functions TNFSF13 had, and list some proteins which have the same functions with TNFSF13. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| receptor binding | PPY,HAO1,HLA-B,F7,TNFSF8,ABCA1,EPB49,GFRA1,DECR2,FRK |
| cytokine activity | TIMP1,TGFB1,GDF2,ADIPOQ,IL1B,GDF6B,NAMPT,INHBAA,BMP15,OSM |
| tumor necrosis factor receptor binding | FADD,TRADD,TRAF6,CD70,LTB,TRAF4,LTA,TNFSF12,TRAF3,TNFB |
Interacting Protein
TNFSF13 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TNFSF13 here. Most of them are supplied by our site. Hope this information will be useful for your research of TNFSF13.
TNFRSF13B;KRAS;PIK3CA;CAMK1D
TNFSF13 Related Signal Pathway
Resources
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References
- Osorio, C; Chacon, PJ; et al. Selective regulation of axonal growth from developing hippocampal neurons by tumor necrosis factor superfamily member APRIL. MOLECULAR AND CELLULAR NEUROSCIENCE 59:24-36(2014).
- Kutukculer, N; Gulez, N; et al. Three Different Classifications, B Lymphocyte Subpopulations, TNFRSF13B (TACI), TNFRSF13C (BAFF-R), TNFSF13 (APRIL) Gene Mutations, CTLA-4 and ICOS Gene Polymorphisms in Turkish Patients with Common Variable Immunodeficiency. JOURNAL OF CLINICAL IMMUNOLOGY 32:1165-1179(2012).
