Recombinant Human TNFSF13, Fc Chimera

• Cat.No.: TNFSF13-2141H
• Product Overview: Recombinant Human April extracellular domain (N-terminus fused with human IgG1Fc) produced in mammalian cells contains 373 amino acids with predicted MW 41.87 KD x 2 (dimmer) and 8 cysteines (Fc contains 6). It also has 2 N-link glycosylation sites with MW increase up to 10 KD.

Specification

• Species: Human
• Source: Mammalian Cells
• Tag: Fc
• Description: April competes with AGP3 binding to its receptor TACI and BCMA on T and B lymphoma cells , resulting in stimulation of proliferation of primary human and mouse B and T Cells. Well-documented antibodies are available to characterize human April protein.
• Purity: >90%.
• Recommended Storage Temperature: -70 °C.

Gene Information

• Gene Name: TNFSF13 tumor necrosis factor (ligand) superfamily, member 13 [ Homo sapiens ]
• Synonyms: tumor necrosis factor (ligand) superfamily, member 13; APRIL; CD256; TALL2; TRDL-1; ligand; UNQ383/PRO715; TNFSF13; TALL-2; TNF-related death ligand 1; a proliferation inducing ligand; a proliferation-inducing ligand; tumor necrosis factor-related death ligand-1; TNF- and APOL-related leukocyte expressed ligand 2; tumor necrosis factor ligand superfamily member 13 epsilon; tumor necrosis factor (ligand) superfamily member 13 transcript variant delta;ZTNF2; A proliferation-inducing ligand; CD256 antigen
• Gene ID: 8741
• mRNA Refseq: NM_003808
• Protein Refseq: NP_003799
• MIM: 604472
• UniProt ID: O75888
• Chromosome Location: 17p13.1
• Pathway: Cytokine-cytokine receptor interaction; Intestinal immune network for IgA production
• Function: tumor necrosis factor receptor binding; cytokine activity; protein binding; receptor binding