TNFRSF11B
-
Official Full Name
tumor necrosis factor receptor superfamily, member 11b -
Overview
The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein is an osteoblast-secreted decoy receptor that functions as a negative regulator of bone resorption. This protein specifically binds to its ligand, osteoprotegerin ligand, both of which are key extracellular regulators of osteoclast development. Studies of the mouse counterpart also suggest that this protein and its ligand play a role in lymph-node organogenesis and vascular calcification. Alternatively spliced transcript variants of this gene have been reported, but their full length nature has not been determined. [provided by RefSeq, Jul 2008] -
Synonyms
TNFRSF11B;tumor necrosis factor receptor superfamily, member 11b;OPG;TR1;OCIF;tumor necrosis factor receptor superfamily member 11B;osteoprotegerin;osteoclastogenesis inhibitory factor
Recombinant Proteins
- Human
- Mouse
- Chicken
- Rat
- Cynomolgus
- Pig
- Rhesus macaque
- HEK293
- CHO
- Sf21 Cells
- Mammalian Cells
- Human
- Human Cells
- C-His
- Yeast
- E.coli
- Hi-5 Insect Cells
- Insect Cells
- His
- Fc
- Non
- Fc&His
- Avi&Fc&His
- GST&His
- His&MBP
Involved Pathway
TNFRSF11B involved in several pathways and played different roles in them. We selected most pathways TNFRSF11B participated on our site, such as Cytokine-cytokine receptor interaction,Osteoclast differentiation, which may be useful for your reference. Also, other proteins which involved in the same pathway with TNFRSF11B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Osteoclast differentiation | SIRP-BETA,LILRB4,SOCS3,RELB,NOX3,FCGR1,MAP2K6,IL1A,LILRA5,FOSL2 |
| Cytokine-cytokine receptor interaction | M17,MET,CCL21,IL2RGA,CXCR3,TNFRSF10A,CSF1R,KDRL,CCL4L1,IFNA16 |
Protein Function
TNFRSF11B has several biochemical functions, for example, cytokine activity,receptor activity,tumor necrosis factor-activated receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TNFRSF11B itself. We selected most functions TNFRSF11B had, and list some proteins which have the same functions with TNFRSF11B. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| receptor activity | CHRM3,NRP2,NRXN1,CADM2A,TMEM123,CSF2RB,TLR3,RET,RNF139,TACSTD2 |
| tumor necrosis factor-activated receptor activity | CD27,TNFRSF1B,TNFRSF11A,HDR,NGFRB,TNFRSF9A,TNFRSF10B,RELT,TNFRSF9,TNFRSF4 |
| cytokine activity | SPAW,BMP4,IL17C,LFT2,GDF6,IFNPHI3,IFNA16,LTB,BMP3,RNF207B |
Interacting Protein
TNFRSF11B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TNFRSF11B here. Most of them are supplied by our site. Hope this information will be useful for your research of TNFRSF11B.
TNFRSF11B Related Signal Pathway
Resources
Research Area
Cytokine and Growth Factor Receptors on VSMCCytokines and Growth Factors Secreted by VSMC
TNF Receptor
Related Services
Related Products
References
- Chen, XJ; Lu, J; et al. Cytokines in osteoblast-conditioned medium promote the migration of breast cancer cells. TUMOR BIOLOGY 35:791-798(2014).
- Polyzos, SA; Singhellakis, PN; et al. Denosumab Treatment for Juvenile Paget's Disease: Results From Two Adult Patients With Osteoprotegerin Deficiency ("Balkan" Mutation in the TNFRSF11B Gene). JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM 99:703-707(2014).
