Recombinant Mouse Tnfrsf11b, Fc-His

• Cat.No.: Tnfrsf11b-189M
• Product Overview: Recombinant Mouse OPG (Glu22-Leu401) produced inNSO Cellswas fused to Human IgG1 (Pro100-Lys330) - 6xHis tag.

Specification

• Species: Mouse
• Source: Mammalian Cells
• Tag: Fc
• ProteinLength: 22-401 a.a.
• Description: Osteoprotegerin (OPG), also known as osteoclastogenesis inhibitory factor (OCIF) is a cytokine, which can inhibit osteoclast differentiation, activity, and survival. It is a member of the tumor necrosis factor (TNF) receptor superfamily. OPG may provide a pharmacological tool for osteoporotic and erosive bone disorders.
• Molecular Weight: The predicted molecular weight of Recombinant Mouse OPG is Mr 70.9 kDa. However, the actual molecular weight as observed by migration on SDS Page is Mr 100 kDa.
• State Of Matter: Lyophilized.
• Purity: >95% by SDS Page and analyzed by silver stain.
• Endotoxin: <1.0 EU/µg as determined by the LAL method.
• Biological Activity: The biological activity of Mouse OPG was determined by its ability to inhibit TRAIL mediated cytotoxicity using L929 mouse fibrosarcoma cells treated with TRAIL. The expected ED50 for this effect is 25-50 ng/ml in the presence of 50 ng/ml of recombinant human TRAIL.
• Storage And Stability: This lyophilized protein is stable for six to twelve months when stored desiccated at -20°Cto -70°C. After aseptic reconstitution, this protein may be stored at 2°Cto 8°Cfor one month or at -20°Cto -70°Cin a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.

Gene Information

• Gene Name: Tnfrsf11b tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin) [ Mus musculus ]
• Synonyms: Tnfrsf11b; tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin); Opg; TR1; OCIF; osteoprotegerin; osteoclastogenesis inhibitory factor; OPG
• Gene ID: 18383
• mRNA Refseq: NM_008764
• Protein Refseq: NP_032790
• UniProt ID: O08712
• Chromosome Location: 15 D1
• Pathway: Cytokine-cytokine receptor interaction
• Function: protein binding; receptor activity