Pdgfa
-
Official Full Name
platelet-derived growth factor alpha polypeptide -
Overview
The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a motif of eight cysteines. This gene product can exist either as a homodimer or as a heterodimer with the platelet-derived growth factor beta polypeptide, where the dimers are connected by disulfide bonds. Studies using knockout mice have shown cellular defects in oligodendrocytes, alveolar smooth muscle cells, and Leydig cells in the testis; knockout mice die either as embryos or shortly after birth. Two splice variants have been identified for this gene -
Synonyms
PDGFA;platelet-derived growth factor alpha polypeptide;PDGF1;PDGF-A;PDGF A-chain;platelet-derived growth factor alpha chain;Platelet-derived growth factor subunit A;PDGF subunit A;Platelet-derived growth factor A chain;PDGF-1;OTTHUMP00000199955;OTTHUMP00000199956;platelet-derived growth factor alpha isoform 2 preproprotein
Recombinant Proteins
- Mouse
- Human
- Canine
- Rat
- Chicken
- E.coli
- HEK293
- Mammalian Cell
- Yeast
- HEK293T
- Human cells
- Non
- GST
- Fc
- His
- His&S
- His&T7
- HA
- Myc&DDK
- His&Fc&Avi
Involved Pathway
Pdgfa involved in several pathways and played different roles in them. We selected most pathways Pdgfa participated on our site, such as MAPK signaling pathway,Ras signaling pathway,Rap signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with Pdgfa were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Transcriptional misregulation in cancer | GRIA3,HIST1H3I,MET,DOT1L,PROM1,CCNT2,SP1,ATM,REL,ID2 |
| PIK-Akt signaling pathway | TSC1,GYS1,LAMA3,HSP90AA1,SOS1,CASP9,MLST8,MAPK3,CREB5,Gh |
| Melanoma | PIK3CD,HGF,FGF16,FGF2,FGF18,FGF8,PDGFB,PIK3R2,MAP2K2,FGF5 |
| Rap signaling pathway | ID1,PIK3CG,PRKCG,IGF1,Pdgfa&Pdgfb,RAC2,MRAS,FARP2,NGF,PLCB3 |
| Pathways in cancer | ROCK1,TGFBR2,BIRC3,GNAI3,PRKACG,FGFR3,BDKRB2,ITGA2,Adcy4,GNAS |
| Prostate Cancer | LEF1,SMARCA4,INS1,NKX3,NFKBIA,FOXO1,MAP2K1,PIK3R5,PIK3R2,Pdgfa&Pdgfb |
| Choline metabolism in cancer | HRAS,PIK3CB,SLC44A2,PIK3R5,SLC22A5,PLA2G4F,PIP5K1A,PLA2G4A,SLC22A3,GRB2 |
| MAPK signaling pathway | CACNB3,NTF4,RAP1A,FGF10A,PPM1NB,RPS6KA5,JUND,IL1A,MAP3K3,LAMTOR3 |
| HTLV-I infection | FDPS,FOS,H2-AB1,ANAPC4,XPO1,CDC23,SLC2A1,DVL2,WNT11,LCK |
Protein Function
Pdgfa has several biochemical functions, for example, collagen binding,growth factor activity,platelet-derived growth factor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Pdgfa itself. We selected most functions Pdgfa had, and list some proteins which have the same functions with Pdgfa. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| collagen binding | MTAP1A,CD44,ITGA9,LUM,DDR2,RELL2,SERPINH1A,SERPINH1,ITGA1,GP6 |
| protein homodimerization activity | TENM3,PAFAH1B2,ADRB3,DMRT1,GSTZ1,ATF3,ABCG2,ZBTB4,PITX2,BST2 |
| platelet-derived growth factor binding | Pdgfa&Pdgfb,COL2A1,COL5A1,PDGFB,COL3A1,COL1A1,PDGFRA,COL4A1,PDGFRB,COL6A1 |
| protein heterodimerization activity | TWIST1,SMAD2,ZBTB1,HIST1H2BD,EFHA1,RAB3GAP2,BNIP3,HIST1H2BO,TGFB2,EGFR |
| platelet-derived growth factor receptor binding | PDGFD,PDGFAB,PDGFRA,LYN,Pdgfa&Pdgfb,ITGA5,PDGFAA,VEGFA,PTEN,TYMP |
| protein binding | MPPE1,MT3,SUMO1,S100A1,MYBPHL,VPS29,PPIF,PARVA,KRTAP9-2,RTN4 |
| growth factor activity | BMP6,PDGFAB,CXCL1,DKK1,LACRT,OSGIN1,LEP,INHBAB,PDGFC,FGF18 |
Interacting Protein
Pdgfa has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Pdgfa here. Most of them are supplied by our site. Hope this information will be useful for your research of Pdgfa.
PDGFRA;PDGFRB;PDGFB
Resources
Research Area
Angiogenic ActivatorPlatelet-Derived Growth Factors (PDGFs)
Angiogenic Activator in Cancer
Related Services
Related Products
References
- Miller, JD; Benjamin, JT; et al. Chorioamnionitis stimulates angiogenesis in saccular stage fetal lungs via CC chemokines. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY 298:L637-L645(2010).
