NPPB
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Official Full Name
natriuretic peptide B -
Overview
This gene is a member of the natriuretic peptide family and encodes a secreted protein which functions as a cardiac hormone. The protein undergoes two cleavage events, one within the cell and a second after secretion into the blood. The protein's biological actions include natriuresis, diuresis, vasorelaxation, inhibition of renin and aldosterone secretion, and a key role in cardiovascular homeostasis. A high concentration of this protein in the bloodstream is indicative of heart failure. Mutations in this gene have been associated with postmenopausal osteoporosis. -
Synonyms
NPPB;natriuretic peptide B;BNP;natriuretic peptides B;OTTHUMP00000002506;natriuretic protein;brain type natriuretic peptide;gamma-brain natriuretic peptide;natriuretic peptide precursor B;Brain natriuretic peptide;B-type natriuretic peptide
Recombinant Proteins
- Mouse
- Human
- Dog
- Pig
- Rat
- Chicken
- Mammalian Cells
- E.coli
- HEK293
- Protein Conjugation
- Rat
- Wheat Germ
- In Vitro Cell Free System
- Human
- His
- GST
- Non
- His&GST
- N-6×His and C-mFc
- N-6×His and C-mIgG Fc
- His&Fc&Avi
- His&SUMO
- N-His Flag
- Fc
Involved Pathway
NPPB involved in several pathways and played different roles in them. We selected most pathways NPPB participated on our site, such as cGMP-PKG signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with NPPB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| cGMP-PKG signaling pathway | CALM1,SLC25A5,SLC8A1,ATP2A2,ROCK2,VDAC1,ATP1B3,GNA12,MYH7,RHOA |
Protein Function
NPPB has several biochemical functions, for example, diuretic hormone activity,hormone activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NPPB itself. We selected most functions NPPB had, and list some proteins which have the same functions with NPPB. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| hormone activity | MLN,CCK,GCGB,APLN,BMP10,HAMP,SMTLB,GAST,TSHB,UTS1 |
| receptor binding | ABCA1,ADIPOQ,LAMA4,HSD17B4,CADM2,ANKRD13C,CAV1,FGF18A,NUDT19,SRPX2 |
| protein binding | PPFIA2,SULT1E1,ANKRA2,SNX12,RELA,FZD8,USP49,RNF40,C7orf49,TLX3 |
Interacting Protein
NPPB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NPPB here. Most of them are supplied by our site. Hope this information will be useful for your research of NPPB.
PSMA3;KRTAP10-9;KRT40;NOTCH2NL;DPP4;FAP;EWSR1
Resources
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References
- Goswami, SC; Thierry-Mieg, D; et al. Itch-associated peptides: RNA-Seq and bioinformatic analysis of natriuretic precursor peptide B and gastrin releasing peptide in dorsal root and trigeminal ganglia, and the spinal cord. MOLECULAR PAIN 10:-(2014).
- Gallos, G; Remy, KE; et al. Functional expression of the TMEM16 family of calcium-activated chloride channels in airway smooth muscle. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY 305:L625-L634(2013).
