Native Rat Natriuretic Peptide B

• Cat.No.: Nppb-5459R
• Product Overview: Nppb is a 32 aapeptide secreted by the ventricles of the heart in response to excessive stretching of myocytes in the ventricles. A high concentration of thisprotein in the bloodstream is indicative of heart failure.

Specification

• Species: Rat
• Source: Rat
• Tag: Non
• Description: Native Rat Nppb, also known as BrainNatriuretic Peptide-32 (BNP32) is a member of the natriuretic peptide familyand is a secreted protein which functions as a cardiac hormone. The proteinundergoes two cleavage events, one within the cell and a second aftersecretion into the blood. The protein"s biological actions includenatriuresis, diuresis, vasorelaxation, inhibition of renin and aldosteronesecretion, and a key role in cardiovascular homeostasis.
• Form: TrifluoroacetateSalt.
• AA Sequence: Asn-Ser-Lys-Met-Ala-His-Ser-Ser-Ser-Cys-Phe-Gly-Gln-Lys-lle-Asp-Arg-lle-Gly -Ala-Val-Ser-Arg-Leu-Gly-Cys-Asp-Gly-Leu-Arg-Leu-Phe
• Purity: ≥99%
• Storage: Store at -20°C.

Gene Information

• Gene Name: Nppb natriuretic peptide B [ Rattus norvegicus ]
• Official Symbol: Nppb
• Synonyms: NPPB; natriuretic peptide B; natriuretic peptides B; iso-ANP; Brain natriuretic factor; brain natriuretic peptide; gamma-brain natriuretic peptide; natriuretic peptide precursor B; natriuretic peptide precursor type B; BNP; Bnf
• Gene ID: 25105
• mRNA Refseq: NM_031545
• Protein Refseq: NP_113733
• Chromosome Location: 5q36
• Function: hormone activity; peptide hormone receptor binding; receptor binding