Mstn
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Official Full Name
myostatin -
Overview
The protein encoded by this gene is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. This gene is thought to encode a secreted protein which negatively regulates skeletal muscle growth. -
Synonyms
MSTN;myostatin;GDF8;Growth/differentiation factor 8;GDF-8;OTTHUMP00000163498;growth differentiation factor 8
Recombinant Proteins
- Mouse
- Human
- Rat
- Human/Mouse/Rat
- Chicken
- Cattle
- Rhesus macaque
- Cynomolgus
- Pig
- Dog
- Cat
- Horse
- HEK293
- E.coli
- Nicotiana Benthamiana
- Mammalian cells
- NS0
- Mammalian Cell
- Wheat Germ
- HEK293F
- Human Cell
- HEK293T
- In Vitro Cell Free System
- Fc
- Non
- His
- GST
- Myc&DDK
- His&Fc&Avi
- N-His&C-Myc
Involved Pathway
Mstn involved in several pathways and played different roles in them. We selected most pathways Mstn participated on our site, such as Hypertrophy Model, which may be useful for your reference. Also, other proteins which involved in the same pathway with Mstn were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Hypertrophy Model | ADAM10A,WDR1,MYOG,MSTNB,CYR61,JUND,HBEGFB,IFRD1,DUSP14,ZEB1B |
Protein Function
Mstn has several biochemical functions, for example, cytokine activity,growth factor activity,heparin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Mstn itself. We selected most functions Mstn had, and list some proteins which have the same functions with Mstn. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| identical protein binding | SORD,DVL2,RAD51,MYOM1,MCIN,DRG1,SMG9,PAFAH1B3,TRP53,CLDN16 |
| heparin binding | NRP1A,APOB,FGFR4,BSPH1,CYR61,ZNF207,APOA5,LIPH,SELL,THBS4 |
| cytokine activity | IL29,LEFTY1,INHBC,FASLG,IFNL3,RNF207B,IL9,Ccl27a,CCL20A.3,IL17A |
| receptor binding | RND1,GSTM7,NSG1,Ren1,STRAP,WIPI1,GDNF,CX3CL1,NTF3,NPY |
| protein binding | MALL,EIF4EBP1,TSHR,NUP98,MRPL9,RNF213,NPDC1,CD72,NFKBID,DPYSL4 |
| growth factor activity | GDF9,NRG2,CNTF,GDF6B,VEGFB,FGF14,IL7,THPO,OSGIN1,NDR1 |
| transforming growth factor beta receptor binding | GDF9,NDR1,BMP3,TGFBR3,TGFB2,BMP8A,BMP8B,GDF2,USP15,AMH |
Interacting Protein
Mstn has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Mstn here. Most of them are supplied by our site. Hope this information will be useful for your research of Mstn.
FURIN;BMP1;WFIKKN1;ACVR2B
Resources
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References
- Tang, L; Liu, CT; et al. A prepared anti-MSTN polyclonal antibody reverses insulin resistance of diet-induced obese rats via regulation of PI3K/Akt/mTOR&FoxO1 signal pathways. BIOTECHNOLOGY LETTERS 36:2417-2423(2014).
- Bialek, P; Parkington, J; et al. A myostatin and activin decoy receptor enhances bone formation in mice. BONE 60:162-171(2014).
