KRAS

  • Official Full Name

    v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog

  • Overview

    GTPase KRas also known as V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog and KRAS, is a protein that in humans is encoded by the KRAS gene. Like other members of the Ras family, the KRAS protein is a GTPase and is an early player in many signal transduction pathways. KRAS is usually tethered to cell membranes because of the presence of an isoprenyl group on its C-terminus. The protein product of the normal KRAS gene performs an essential function in normal tissue signaling, and the mutation of a KRAS gene is an essential step in the development of many cancers.

  • Synonyms

    KRAS;v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog;KRAS2, v Ki ras2 Kirsten rat sarcoma 2 viral oncogene homolog;GTPase KRas;KRAS1;K-Ras 2;c-Ki-ras;oncogene KRAS2;K-ras p21 protein;c-Kirsten-ras protein;PR310 c-K-ras oncogene;transformi

Recombinant Proteins

  • Human
  • Zebrafish
  • Rhesus macaque
  • Chicken
  • Mouse
  • E.coli
  • Human Cells
  • Mammalian Cells
  • HEK293
  • Sf9 Cells
  • Insect Cells
  • Wheat Germ
  • In Vitro Cell Free System
  • His
  • Flag
  • Non
  • DDK&Myc
  • Avi&His
  • Avi
  • GST
  • Avi&Fc&His
Cat.# Product name Source (Host) Species Tag Protein Length Price
KRAS-2569H Recombinant Human KRAS, His-tagged E.coli Human His
KRAS-01H Recombinant Human KRAS G12D mutant Protein, DYKDDDDK-tagged Human Cells Human Flag
KRAS-02H Recombinant Human KRAS (G12D) Protein, His-tagged E.coli Human His 2-186 a.a.
KRAS-078H Recombinant Human KRAS G13D mutant Protein, DYKDDDDK-tagged Human Cells Human Flag
KRAS-079H Recombinant Human KRAS G12V mutant Protein, DYKDDDDK-tagged Human Cells Human Flag
KRAS-080H Recombinant Human KRAS G12S mutant Protein, DYKDDDDK-tagged Human Cells Human Flag
KRAS-081H Recombinant Human KRAS G12D mutant Protein, DYKDDDDK-tagged Human Cells Human Flag
KRAS-082H Recombinant Human KRAS G12C mutant Protein, DYKDDDDK-tagged Human Cells Human Flag
KRAS-083H Recombinant Human KRAS G12A mutant Protein, DYKDDDDK-tagged Human Cells Human Flag
KRAS-3965HAF488 Recombinant Human KRAS Protein, His-tagged, Alexa Fluor 488 conjugated E.coli Human His 195
KRAS-3965HAF555 Recombinant Human KRAS Protein, His-tagged, Alexa Fluor 555 conjugated E.coli Human His 195
KRAS-3965HAF647 Recombinant Human KRAS Protein, His-tagged, Alexa Fluor 647 conjugated E.coli Human His 195
KRAS-3965HF Recombinant Human KRAS Protein, His-tagged, FITC conjugated E.coli Human His 195
KRAS-455HAF488 Recombinant Human KRAS Protein, His-tagged, Alexa Fluor 488 conjugated E.coli Human His 202
KRAS-455HAF555 Recombinant Human KRAS Protein, His-tagged, Alexa Fluor 555 conjugated E.coli Human His 202
KRAS-455HAF647 Recombinant Human KRAS Protein, His-tagged, Alexa Fluor 647 conjugated E.coli Human His 202
KRAS-455HF Recombinant Human KRAS Protein, His-tagged, FITC conjugated E.coli Human His 202
KRAS-456HAF488 Recombinant Human KRAS Protein, His-tagged, Alexa Fluor 488 conjugated E.coli Human His 202
KRAS-456HAF555 Recombinant Human KRAS Protein, His-tagged, Alexa Fluor 555 conjugated E.coli Human His 202
KRAS-456HAF647 Recombinant Human KRAS Protein, His-tagged, Alexa Fluor 647 conjugated E.coli Human His 202
KRAS-456HF Recombinant Human KRAS Protein, His-tagged, FITC conjugated E.coli Human His 202
KRAS-457H Recombinant Human KRAS protein(G12C, Q61H), His-tagged E.coli Human His Thr2-Cys185
KRAS-1084Z Recombinant Zebrafish KRAS Mammalian Cells Zebrafish His
KRAS-1246H Recombinant Human V-Ki-ras2 Kirsten Rat Sarcoma Viral Oncogene Homolog E.coli Human Non
KRAS-163H Recombinant Human KRAS protein, MYC/DDK-tagged HEK293 Human DDK&Myc
KRAS-2443R Recombinant Rhesus monkey KRAS Protein, His-tagged Mammalian Cells Rhesus macaque His
KRAS-29908TH Recombinant Human KRAS E.coli Human Non Full L.
KRAS-325H Recombinant Human KRAS protein(Thr2-Cys185(61Q)), His-tagged E.coli Human His Thr2-Cys185(61Q)
KRAS-455H Recombinant Human KRAS Protein, His-tagged E.coli Human His 2-185 a.a.
KRAS-456H Recombinant Human KRAS G12C Protein, His-tagged E.coli Human His Thr2-Cys185, with natural variant Gly 12 Cys
KRAS-4583C Recombinant Chicken KRAS Mammalian Cells Chicken His
KRAS-547H Recombinant Human Kirsten rat sarcoma viral oncogene homolog, His-tagged E.coli Human His 1-186 a.a.
KRAS-8806M Recombinant Mouse KRAS Protein Mammalian Cells Mouse His
KRAS-4885HCL Recombinant Human KRAS 293 Cell Lysate HEK293 Human Non
KRAS-031H Recombinant Human KRAS Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 Human DDK&Myc
KRAS-03H Recombinant Human KRAS Protein, DYKDDDDK-tagged Human Cells Human Flag
KRAS-04H Recombinant Human KRAS Protein, Myc/DDK-tagged HEK293 Human DDK&Myc
KRAS-05H Recombinant Human KRAS proto-oncogene, GTPase Protein, G12R Mutant, His&Avi tagged, Biotinylated E.coli Human Avi&His 1-185 aa
KRAS-06H Recombinant Human KRAS proto-oncogene, GTPase Protein, His&Avi tagged, Biotinylated E.coli Human Avi&His 1-166 aa
KRAS-07H Recombinant Human KRAS Q61H Protein, AviTag™ E.coli Human Avi 1-185
KRAS-084H Recombinant Human KRAS Protein, DYKDDDDK-tagged Human Cells Human Flag
KRAS-085H Recombinant Human KRAS Protein, DYKDDDDK-tagged Human Cells Human Flag
KRAS-08H Recombinant Human KRAS Q61H Protein, AviTag™, Biotinylated E.coli Human Avi 1-185
KRAS-0944H Recombinant Human KRAS Protein (M1-K169), Tag Free E.coli Human Non M1-K169
KRAS-0945H Recombinant Human KRAS (G12V) Protein (2-186), N-His tagged E.coli Human His 2-186
KRAS-0946H Recombinant Human KRAS Protein (T2-K169, G12S), Tag Free E.coli Human Non T2-K169, G12S
KRAS-0947H Recombinant Human KRAS Protein (T2-K169, G12D), Tag Free E.coli Human Non T2-K169, G12D
KRAS-0948H Recombinant Human KRAS Protein (T2-K169, G13D), Tag Free E.coli Human Non T2-K169, G13D
KRAS-0949H Recombinant Human KRAS Protein (T2-K169, G12C), Tag Free E.coli Human Non T2-K169, G12C
KRAS-0950H Recombinant Human KRAS Protein (T2-K169), Tag Free E.coli Human Non T2-K169
KRAS-0951H Recombinant Human KRAS Protein (T2-K169, G12A), Tag Free E.coli Human Non T2-K169, G12A
KRAS-0952H Recombinant Human KRAS Protein (T2-K169, G12R), Tag Free E.coli Human Non T2-K169, G12R
KRAS-0953H Recombinant Human KRAS Protein (M1-K169), His tagged E.coli Human His M1-K169
KRAS-0954H Recombinant Human KRAS Protein (T2-K169, G12V), GST tagged E.coli Human GST T2-K169, G12V
KRAS-0955H Recombinant Human KRAS Protein (T2-K169, G12S), GST tagged E.coli Human GST T2-K169, G12S
KRAS-0956H Recombinant Human KRAS Protein (T2-K169, G12D), GST tagged E.coli Human GST T2-K169, G12D
KRAS-0957H Recombinant Human KRAS Protein (T2-K169, G13D), GST tagged E.coli Human GST T2-K169, G13D
KRAS-0958H Recombinant Human KRAS Protein (T2-K169, G12C), GST tagged E.coli Human GST T2-K169, G12C
KRAS-0959H Recombinant Human KRAS Protein (T2-K169), GST tagged E.coli Human GST T2-K169
KRAS-0960H Recombinant Human KRAS Protein (T2-K169, G12A), GST tagged E.coli Human GST T2-K169, G12A
KRAS-0961H Recombinant Human KRAS Protein (T2-K169, G12R), GST tagged E.coli Human GST T2-K169, G12R
KRAS-0962H Recombinant Human KRAS Protein (M1-M188, Q61K), Biotinylated tagged E.coli Human M1-M188, Q61K
KRAS-0963H Recombinant Human KRAS Protein (M1-M188, Q61R), Biotinylated tagged E.coli Human M1-M188, Q61R
KRAS-09H Recombinant Human KRAS G12C Protein, AviTag™, Biotinylated E.coli Human Avi 1-185
KRAS-100H Recombinant Human KRAS G12D, Isoform A, GppNHp-loaded, N-His-tagged E.coli Human His 2-186
KRAS-101H Recombinant Human KRAS G12D, Isoform A, GDP-loaded, N-His-tagged E.coli Human His 2-186
KRAS-102H Recombinant Human KRAS, Isoform B, BODIPY-GDP Loaded, N-His-tagged Sf9 Cells Human His 2-186
KRAS-103H Recombinant Human KRAS, Isoform B, GDP-Loaded, N-His-tagged Sf9 Cells Human His 2-186
KRAS-10H Recombinant Human KRAS (G12C) Mutant Protein, His-tagged E.coli Human His 2-186 a.a.
KRAS-11H Recombinant Human KRAS G12V Protein, AviTag™, Biotinylated E.coli Human Avi 1-185
KRAS-1232H Recombinant Human KRAS protein, His-tagged E.coli Human His Thr2-Cys185(G12C)
KRAS-1264H Recombinant Human KRAS Protein, His (Fc)-Avi-tagged HEK293 Human Avi&Fc&His
KRAS-1264H-B Recombinant Human KRAS Protein Pre-coupled Magnetic Beads HEK293 Human
Kras-1283M Recombinant Mouse Kras Protein, MYC/DDK-tagged HEK293 Mouse DDK&Myc
KRAS-12H Recombinant Human KRAS G13D Protein, AviTag™, Biotinylated E.coli Human Avi 1-185
KRAS-13H Recombinant Human KRAS (G12D) Protein (1-186), N-His-tagged E.coli Human His 1-186
KRAS-14H Recombinant Human KRAS G12D Protein, Avi Tag E.coli Human Avi 1-185
KRAS-15H Recombinant Human KRAS G12D protein, Avi Tag, Biotinylated E.coli Human Avi 1-185
KRAS-16H Recombinant Human KRAS G12V Protein, Avi Tag E.coli Human Avi 1-185
KRAS-17H Recombinant Human KRAS G13D Protein, Avi Tag E.coli Human Avi 1-185
KRAS-19H Recombinant Human KRAS protein, His-tagged Insect Cells Human His Met 1 - Lys 169
KRAS-2227H Recombinant Human KRAS protein, His-Avi-tagged, Biotinylated E.coli Human Avi&His Thr2-Cys185(G12D)
KRAS-224H Recombinant Human KRAS Protein, His-tagged(N-ter) E.coli Human His Thr2-Cys186
KRAS-2264R Recombinant Rhesus Macaque KRAS Protein, His (Fc)-Avi-tagged HEK293 Rhesus macaque Avi&Fc&His
KRAS-2264R-B Recombinant Rhesus Macaque KRAS Protein Pre-coupled Magnetic Beads HEK293 Rhesus macaque
KRAS-3259H Recombinant Human KRAS protein(Thr2-Cys185(G12D)), His-tagged E.coli Human His Thr2-Cys185(G12D)
KRAS-33H Recombinant Human KRAS Protein (1-186aa), N-His tagged E.coli Human His 1-186aa
KRAS-3489H Active Recombinant Human KRAS Protein, His-tagged E.coli Human His 2-186 a.a.
KRAS-34H Recombinant Human KRAS G12C mutant Protein, His-tagged E.coli Human His
KRAS-358H Recombinant Human KRAS Protein, His-tagged E.coli Human His
KRAS-40HFL Recombinant Full Length Human KRAS Protein, C-Flag-tagged Mammalian Cells Human Flag Full L.
KRAS-4373H Recombinant Human KRAS Protein (Met1-Met188), N-His tagged E.coli Human His Met1-Met188
KRAS-4374H Recombinant Human KRAS Protein (Met1-Val186), C-His tagged Mammalian Cells Human His Met1-Val186
KRAS-4376H Recombinant Human KRAS Protein (Met1-Arg149), N-His tagged E.coli Human His Met1-Arg149
KRAS-4377H Recombinant Human KRAS Protein (Met1-Met188), N-GST tagged E.coli Human GST Met1-Met188
KRAS-4378H Recombinant Human KRAS Protein (Thr2-Cys184), N-His tagged E.coli Human His Thr2-Cys184
KRAS-450H Recombinant Human KRAS(Met1-Lys169(Gly12Cys)) Protein, N-6*His-tagged E.coli Human His 1-169 a.a.
KRAS-451H Recombinant Human KRAS(Met1-Lys169) Protein, N-6*His-tagged E.coli Human His 1-169 a.a.
KRAS-452H Recombinant Human KRAS(Met1-Lys169) Protein, N-6*His-tagged E.coli Human His 1-169 a.a.
KRAS-454H Recombinant Human KRAS(Thr2-Cys185(Gly12Val)) Protein, N-6*His-tagged E.coli Human His 2-185 a.a.
KRAS-458H Recombinant Human KRAS protein(G12D, Q61H), His-tagged E.coli Human His Thr2-Cys185
KRAS-459H Recombinant Human KRAS(Thr2-Cys185(Gly12 Ser)) Protein, N-6*His-tagged E.coli Human His 2-185 a.a.
KRAS-4888H Recombinant Human KRAS Protein, GST-tagged Wheat Germ Human GST
KRAS-4903M Recombinant Mouse KRAS Protein, His (Fc)-Avi-tagged HEK293 Mouse Avi&Fc&His
KRAS-4903M-B Recombinant Mouse KRAS Protein Pre-coupled Magnetic Beads HEK293 Mouse
KRAS-5845HF Recombinant Full Length Human KRAS Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 188 amino acids
KRAS-66H Recombinant Human KRAS Protein (G12C), GST-Tagged E.coli Human GST
KRAS-67H Recombinant Human KRAS Protein (G12R), GST-Tagged, GppNHp Loaded E.coli Human GST
KRAS-68H Recombinant Human KRAS Protein (G12V), GST-Tagged, GppNHp Loaded E.coli Human GST
KRAS-75H Recombinant Human KRAS Protein, GST-tagged E.coli Human GST 188

    Involved Pathway

    KRAS involved in several pathways and played different roles in them. We selected most pathways KRAS participated on our site, such as MAPK signaling pathway,ErbB signaling pathway,Ras signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with KRAS were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Tight junction GNAI2B,CLDN4,ACTN2,ACTN1,EPB41L1,CASK,MYL7,LLGL1,PARD6A,CLDN2
    GnRH signaling pathway CAMK2G,MAP2K3,CAMK2B,LHBETA1,CDC42L2,GNRH3,GNRHR4,PRKACG,MAP2K7,CALM3
    Phospholipase D signaling pathway PLA2G4F,CYTH2,CYTH4,PDGFD,PIP5K1A,SHC1,Pdgfa&Pdgfb,INSR,PTGFR,GRM1
    Cholinergic synapse GNG5,Adcy4,CREB3L3,CHRNA3,PIK3CD,GNAI3,GNA11,CREB3L1,GNAI1,PLCB4
    Insulin signaling pathway SOCS2,MTOR,PRKAR1A,TRIP10,MAPK3,PPP1CAA,RPS6KB1B,IRS1,PYGL,CALM1B
    VEGF signaling pathway PPP3R1B,CDC42,PIK3CD,PPP3R2,RAC3B,PIK3R3,PRKCG,BADB,PTGS2,RAF1
    Sphingolipid signaling pathway LASS4,PIK3CB,PDPK1,PPP2R3C,AKT2,NSMAF,OPRD1,PPP2R2B,DEGS1,MAPK1
    Dorso-ventral axis formation GRB2,PIWIL1,PIWIL4,GRB2B,NOTCH4,PPP1R2P9,NOTCH1A,ETV6,SPIRE2,GRB2A
    Central carbon metabolism in cancer RAF1,PDHA2,PFKL,PIK3CB,MAP2K2,PIK3CD,PDGFRA,PIK3CG,PDK1,PGAM1

    Protein Function

    KRAS has several biochemical functions, for example, GDP binding,GMP binding,GTP binding. Some of the functions are cooperated with other proteins, some of the functions could acted by KRAS itself. We selected most functions KRAS had, and list some proteins which have the same functions with KRAS. You can find most of the proteins on our site.

    Function Related Protein
    protein binding COL4A3BP,ZFP110,C22orf28,ACE,MTUS2,CREB3,INO80,ADAMTSL5,CAMTA2,SP4
    GTP binding RAB18B,ANXA6,RHOC,GTPBP4,SEPT2,DNM3,ARHGAP5,ARF1,TUBA3D,RAB3AA
    LRR domain binding ZXDC,STK11,POLR2J,LRRFIP2,ROBO1
    GDP binding RAB27B,RAB5C,SRP54,RAN,TRIM23,RAB28,RAP1B,EIF2B1,ARL2,SEPT12
    protein complex binding BRK1,Ctsl,C8A,SH2B3,RAP1A,CPD,PRKACA,MYC,ATP6V1B1,PPARA
    GMP binding RAB26

    Interacting Protein

    KRAS has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KRAS here. Most of them are supplied by our site. Hope this information will be useful for your research of KRAS.

    ARAF;RASSF2;gtp;q46342_closo;Pik3ca;Rassf5;PIK3R2;RGL2;DEAF1;FRAT2;ZNF189;TNFSF13;DIRAS3;MOCS2;MT-CYB

    KRAS Related Signal Pathway

    Resources

    Gene Families

    TGF-β Superfamily Signaling

    Research Area

    Cancer Drug Targets
    Ovarian Cancer Biomarkers
    Pancreatic Cancer Biomarkers
    Tumor Antigens
    Oncoprotein-Signal Transducers
    RAS-MAPK Pathway

    References

    • Bettington, ML; Walker, NI; et al. A clinicopathological and molecular analysis of 200 traditional serrated adenomas. MODERN PATHOLOGY 28:414-427(2015).
    • Puzanov, I; Lindsay, CR; et al. A Phase I Study of Continuous Oral Dosing of OSI-906, a Dual Inhibitor of Insulin-Like Growth Factor-1 and Insulin Receptors, in Patients with Advanced Solid Tumors. CLINICAL CANCER RESEARCH 21:701-711(2015).

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