CXCL1
-
Official Full Name
chemokine (C-X-C motif) ligand 1 -
Overview
This gene encodes a protein that is a member of the CXC subfamily of chemokines. Chemokines, which recruit and activate leukocytes, are classified by function (inflammatory or homeostatic) or by structure. This secretory protein is proposed to bind the G-protein coupled receptor chemokine (C-X-C motif) receptor 2 to recruit neutrophils. In mouse, deficiency of this gene is associated with colitis and with defects in immune cell recruitment to the lung. [provided by RefSeq, Apr 2013] -
Synonyms
CXCL1;chemokine (C-X-C motif) ligand 1;KC;Fsp;N51;gro;Gro1;Mgsa;Scyb1;growth-regulated alpha protein;KC/GR)-alpha;KC/GRO-alpha;GRO1 oncogene;alpha-chemokine;secretory protein N51;C-X-C motif chemokine 1;platelet-derived growth factor-inducible protein KC
Recombinant Proteins
- Human
- Pan troglodytes
- Mouse
- Cotton Rat
- Rhesus macaque
- Rat
- Cynomolgus
- E.coli
- CHO
- Mammalian Cell
- Human Cell
- HEK293F
- HEK293
- Human Cells
- E. coli
- Mammalian cells
- In Vitro Cell Free System
- His
- N-His&NusA
- Fc
- Non
- MBP
- StrepII
- His&GST
- His&T7
- His&MBP
- His&Fc&Avi
- Flag
- GST
- His&SUMO
Involved Pathway
CXCL1 involved in several pathways and played different roles in them. We selected most pathways CXCL1 participated on our site, such as Cytokine-cytokine receptor interaction,Chemokine signaling pathway,NOD-like receptor signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CXCL1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Amoebiasis | RAB7B,PRKCB,SERPINB6B,HSPB1,GM-CSF,ARG1,COL27A1,NFKB1,LAMA3,LAMA1 |
| Chemokine signaling pathway | PIK3R5,CCL4L1,CCR5,VAV2,PIK3CA,RELA,ADRBK1,CXCR5,CCL21,GNAI1 |
| NOD-like receptor signaling pathway | CARD18,CCL2,MAPK14A,CASPA,MAPK12,HSP90AA1.2,CCL5,NFKB1,CARD9,ERBB2IP |
| Cytokine-cytokine receptor interaction | CCR9,CSH,IL21,IL1R2,IL17B,CXCL12A,INHBC,IFNGR1,CCL17,CCL25B |
| Epithelial cell signaling in Helicobacter pylori infection | JAM3,JAM2,CXCR2,ATP6AP1,MAPK9,IKBKG,NFKBIA,PTPN11,NFKB1,ATP6V1G3 |
| Salmonella infection | IL1A,ROCK2,DYNC1LI1,NOS2,PFN4,TLR4BB,WASLB,ROCK1,NOS2B,RHOGD |
| TNF signaling pathway | VEGFC,PIK3R2,PGAM5,PIK3R1,FADD,CREB3L2,MMP14,MLKL,RIPK1,TNFRSF1B |
| Legionellosis | TLR5,C3,BCL2L13,EEF1G,TLR2,CASP7,CASP9,Itgam&Itgb2,RAB1B,NLRC4 |
| Rheumatoid arthritis | HLA-DRB3,MMP3,ITGB2L,TNFRSF11A,CCL5,HLA-DOB,CXCL5,TNFSF11,ATP6V1F,TNFSF13 |
Protein Function
CXCL1 has several biochemical functions, for example, CXCR chemokine receptor binding,chemokine activity,enzyme activator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CXCL1 itself. We selected most functions CXCL1 had, and list some proteins which have the same functions with CXCL1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| enzyme activator activity | ARL1,TAB1,DCP1A,CTSA,CLPS,MGST2,ALDH1A2,LTC4S,PITRM1,MMP16 |
| receptor binding | YES1,NPFFL,UFD1L,IL28A,NPFF,IL29,CXCL10,ADM,TYROBP,F2 |
| growth factor activity | DKK1,TGFA,FGF20A,TGFB1,PDGFD,FGF10B,CTGF,LIF,GDF10,CDNF |
| chemokine activity | CCL44,CXCL6,CCL1,CCL19B,CCL27,CCL34B.1,CCL2,PPBP,PF4,CCL33.3 |
| CXCR chemokine receptor binding | AMCF-II,CXCL6,CXCL2,CXCL18B,CXCL12B,CXCL12,CXCL20,PF4V1,CXCL12A,CXCL3 |
Interacting Protein
CXCL1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CXCL1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CXCL1.
XRCC3;HRAS;ESR1;PTEN;purL
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References
- McDermott, AJ; Higdon, KE; et al. The role of Gr-1(+) cells and tumour necrosis factor-alpha signalling during Clostridium difficile colitis in mice. IMMUNOLOGY 144:704-716(2015).
- Lee, YH; Shynlova, O; et al. Stretch-induced human myometrial cytokines enhance immune cell recruitment via endothelial activation. CELLULAR & MOLECULAR IMMUNOLOGY 12:231-242(2015).
