TMPRSS2
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Official Full Name
transmembrane protease, serine 2 -
Overview
This gene encodes a protein that belongs to the serine protease family. The encoded protein contains a type II transmembrane domain, a receptor class A domain, a scavenger receptor cysteine-rich domain and a protease domain. Serine proteases are known to be involved in many physiological and pathological processes. This gene was demonstrated to be up-regulated by androgenic hormones in prostate cancer cells and down-regulated in androgen-independent prostate cancer tissue. The protease domain of this protein is thought to be cleaved and secreted into cell media after autocleavage. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. -
Synonyms
TMPRSS2;transmembrane protease, serine 2;transmembrane protease serine 2;PRSS10;Transmembrane protease, serine 2, EC 3.4.219;D16Ertd61e;Epitheliasin;FLJ41954;MGC6821;PP9284;Serine protease 10;TMPRSS2 ERG FUSION GENE, INCLUDED;TMPRSS2 ETV1 FUSION GENE, INCLUDED;TMPS2_HUMAN;Transmembrane protease serine 2 catalytic chain
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- Rat
- Yeast
- E.coli
- Human Cells
- Mammalian Cells
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- His
- Non
- His&T7
- Avi&His&MBP
- GST
- Flag&His&Myc
- His&SUMO
- His&Myc
Involved Pathway
TMPRSS2 involved in several pathways and played different roles in them. We selected most pathways TMPRSS2 participated on our site, such as Influenza A,Transcriptional misregulation in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with TMPRSS2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Transcriptional misregulation in cancer | PLAU,CCNA1,SS18,ETV4,SSX2,HOXA9,CD40,PAX7,GOLPH3,HIST3H3 |
| Influenza A | IFNA21,TLR3,HLA-DRA,PIK3CD,EIF2AK1,BLA,IFNB,NFKBIB,NFKB1,IFNA6 |
Protein Function
TMPRSS2 has several biochemical functions, for example, protein binding,scavenger receptor activity,serine-type endopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TMPRSS2 itself. We selected most functions TMPRSS2 had, and list some proteins which have the same functions with TMPRSS2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| scavenger receptor activity | ACKR4,TMPRSS4A,SCARA5,LOXL2,TMPRSS4B,LOXL2B,TMPRSS5,MARCO,CD5L,PRG4B |
| serine-type peptidase activity | Gzmg,TMPRSS4A,DPP10,KLK1B3,ST14,ELA3L,C1rb,CMA1,SLC38A8,GZMC |
| serine-type endopeptidase activity | CELA2A,KLK1B3,ST14B,HTRA1A,LOC100686744,MCPT1,LPA,FURINB,HPR,MASP2 |
| protein binding | THOC2,SR140,HPN,ATG4A,BMP2,LGALS8,HSP90AA1.2,CITED2,PRDX1,DVL3 |
Interacting Protein
TMPRSS2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TMPRSS2 here. Most of them are supplied by our site. Hope this information will be useful for your research of TMPRSS2.
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References
- Gierer, S; Muller, MA; et al. Inhibition of Proprotein Convertases Abrogates Processing of the Middle Eastern Respiratory Syndrome Coronavirus Spike Protein in Infected Cells but Does Not Reduce Viral Infectivity. JOURNAL OF INFECTIOUS DISEASES 211:889-897(2015).
- Yang, F; Chen, YZ; et al. Stromal TGF-beta signaling induces AR activation in prostate cancer. ONCOTARGET 5:10854-10869(2014).
