Recombinant Human TMPRSS2 Protein, His-tagged

Cat.No. : TMPRSS2-427H
Product Overview : Recombinant Human TMPRSS2 Protein (Trp106-Gly492) with N-His tag was expressed in E. coli.
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Species : Human
Source : E.coli
Tag : His
Protein Length : Trp106-Gly492
Description : This gene encodes a protein that belongs to the serine protease family. The encoded protein contains a type II transmembrane domain, a receptor class A domain, a scavenger receptor cysteine-rich domain and a protease domain. Serine proteases are known to be involved in many physiological and pathological processes. This gene was demonstrated to be up-regulated by androgenic hormones in prostate cancer cells and down-regulated in androgen-independent prostate cancer tissue. The protease domain of this protein is thought to be cleaved and secreted into cell media after autocleavage. This protein also facilitates entry of viruses into host cells by proteolytically cleaving and activating viral envelope glycoproteins. Viruses found to use this protein for cell entry include Influenza virus and the human coronaviruses HCoV-229E, MERS-CoV, SARS-CoV and SARS-CoV-2 (COVID-19 virus). Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Form : Freeze-dried powder
Molecular Mass : Predicted Molecular Mass: 46.5 kDa
Accurate Molecular Mass: 44 kDa
Purity : > 95%
Applications : Positive Control; Immunogen; SDS-PAGE; WB.
Stability : The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 centigrade for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
Storage : Avoid repeated freeze/thaw cycles. Store at 2-8 centigrade for one month. Aliquot and store at -80 centigrade for 12 months.
Storage Buffer : 20mM Tris, 150mM NaCl, pH8.0, containing 1mM EDTA, 1mM DTT, 0.01% SKL, 5% Trehalose and Proclin300.
Reconstitution : Reconstitute in sterile water to a concentration of 0.1-1.0 mg/mL. Do not vortex.
Gene Name TMPRSS2 transmembrane protease, serine 2 [ Homo sapiens (human) ]
Official Symbol TMPRSS2
Synonyms TMPRSS2; transmembrane protease, serine 2; transmembrane protease serine 2; PRSS10; epitheliasin; serine protease 10; PP9284; FLJ41954
Gene ID 7113
mRNA Refseq NM_001135099
Protein Refseq NP_001128571
MIM 602060
UniProt ID O15393

Not For Human Consumption!

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