TGFB3
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Official Full Name
transforming growth factor, beta 3 -
Overview
This gene encodes a member of the TGF-beta family of proteins. The encoded protein is secreted and is involved in embryogenesis and cell differentiation. Defects in this gene are a cause of familial arrhythmogenic right ventricular dysplasia 1. -
Synonyms
TGFB3;transforming growth factor, beta 3;ARVD;FLJ16571;TGF-beta3;transforming growth factor beta-3;TGF-beta-3;MGC105479;MGC118722;TGF beta 3;TGF beta3;TGFB 3;TGFB3_HUMAN;transforming growth factor beta 3;OTTHUMP00000246179;OTTHUMP00000246180
Recombinant Proteins
- Rat
- Human
- Bovine
- Cattle
- Pig
- Rhesus macaque
- Chicken
- Zebrafish
- Rabbit
- Mouse
- Human/Mouse
- E. coli
- E.coli
- CHO
- Nicotiana Benthamiana
- HEK293
- CHO Cells
- Sf21 Insect Cell
- Mammalian Cell
- Insect Cell
- Human Cell
- Mammalian cells
- HEK293T
- Human cells
- C-Avi
- His
- Non
- His&Avi
- His&GST
- His&T7
- Fc
- Flag
- His&Fc&Avi
- Myc&DDK
- His&SUMO
Involved Pathway
TGFB3 involved in several pathways and played different roles in them. We selected most pathways TGFB3 participated on our site, such as MAPK signaling pathway,Cytokine-cytokine receptor interaction,FoxO signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with TGFB3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Chronic myeloid leukemia | AKT2,PTPN11,PIK3R3,MAPK1,BCL2L1,KRAS,STAT5A,NFKBIA,CRKL,SHC1 |
| Malaria | TNF,GYPC,SELE,HBB,ITGAL,COMP,THBS1,IFNG,THBS3,TLR9 |
| MAPK signaling pathway | FGF5,MAP2K5,TGFBR1B,PPP3R1B,PPM1AB,PTPRR,RAP1AB,FGFR1,PPM1BA,IL1A |
| Leishmaniasis | HLA-DOB,ITGB2,FCGR1A,HLA-DOA,TRAF6,IL4,IL1A,H2-AA,NFKB1,IFNG |
| Dilated cardiomyopathy | ITGB1,CACNG6,ITGB5,Adcy4,CACNA2D1,LMNA,TTN,SGCD,SGCB,SLC8A1 |
| Pathways in cancer | FZD1,IGF1R,WNT3,KIT,Casp3,FASLG,BCR,CSF3R,MAP2K1,PLCB2 |
| HTLV-I infection | PPP3CC,TERT,BUB1B,VDAC3,PTTG1,VCAM1,GPS2,HLA-E,PTTG2,XIAP |
| Rheumatoid arthritis | TNFSF13B,Il23a; Il12b,TLR4,HLA-DMA,HLA-DQA2,MMP3,ITGB2L,Ccl12,ATP6V0B,MMP1 |
| Chagas disease (American trypanosomiasis) | IL6,C1QC,CD3D,PPP2R1A,IFNGR1,IKBKG,GNAI3,FAS,IFNGR2,PPP2CA |
Protein Function
TGFB3 has several biochemical functions, for example, cytokine activity,growth factor activity,identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TGFB3 itself. We selected most functions TGFB3 had, and list some proteins which have the same functions with TGFB3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| identical protein binding | DCP1A,SHANK3,PRPF3,TRA@,RUNX1T1,RAD52,TRIM39,RASSF1,MNS1,SIAH1A |
| type I transforming growth factor beta receptor binding | ENG,FKBP1A,TGFB1,SMAD6,SMAD2,TGFBR2,SMAD7,SNX25 |
| type III transforming growth factor beta receptor binding | TGFB2,TGFB1,TGFBR2 |
| growth factor activity | TFF1,BMP6,CDNF,JAG1,IL11,KLK1B4,SPAW,LACRT,Il2,FGF13B |
| cytokine activity | KITLG,TGFB1A,SP100,AREG,MSTN,BMP8A,BMP3,TNFSF8,IFNA1,IFNA6 |
| protein heterodimerization activity | EXT2,MEF2A,CHRNB2,ZHX2,MLXIPL,ATF1,MAFGB,RELA,TTR,TRP53 |
| type II transforming growth factor beta receptor binding | TGFB2,BAMBI,TGFBR3,ENG,TGFB1A,TGFBR1,TGFB1 |
| transforming growth factor beta binding | THBS1,TGFBR2,CD109,ACVR1,ITGAV,ENG,LTBP4,TGFBR1,ACVRL1,TGFBR3 |
| protein binding | MAGOHB,CD8A,ZNF259,POLG,CLDN8,TP63,TNS1,TACR1,IL1RL1,KIAA1967 |
Interacting Protein
TGFB3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TGFB3 here. Most of them are supplied by our site. Hope this information will be useful for your research of TGFB3.
TGFBR2;TGFBR1;TGFBR3;CHMP2A;SDC4;CCL20
TGFB3 Related Signal Pathway
Resources
Gene Families
What Is Tumor Necrosis Factor (TNF)/TNF SuperfamilyGrowth Factors
TGF-β Superfamily Signaling
Related Services
Related Products
References
- Petra, H; Eva, H; et al. Molecular Profiling of Acute and Chronic Rejections of Renal Allografts. CLINICAL & DEVELOPMENTAL IMMUNOLOGY :-(2013).
- Le, M; Naridze, R; et al. Transforming Growth Factor Beta 3 Is Required for Excisional Wound Repair In Vivo. PLOS ONE 7:-(2012).
Reviews
Q&As
It is a truncated product.