Active Recombinant Human TGFB3 Protein

• Cat.No.: TGFB3-105H
• Product Overview: The mature recombinant human TGF-beta 3 protein consists of 112 amino acids (301-412) without tag was expressed in E. coli.

Specification

• Species: Human
• Source: E.coli
• Description: This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate a latency-associated peptide (LAP) and a mature peptide, and is found in either a latent form composed of a mature peptide homodimer, a LAP homodimer, and a latent TGF-beta binding protein, or in an active form consisting solely of the mature peptide homodimer. The mature peptide may also form heterodimers with other TGF-beta family members. This protein is involved in embryogenesis and cell differentiation, and may play a role in wound healing. Mutations in this gene are a cause of aortic aneurysms and dissections, as well as familial arrhythmogenic right ventricular dysplasia 1.
• Bio-activity: Measured by its ability to inhibit the IL-4-dependent proliferation of HT-2 mouse T cells. The ED50 for this effect is 0.01-0.04 ng/mL.
• Molecular Mass: 12.7 kDa
• Product-Related Proteins: 301-412
• Storage: At -80 centigrade. Avoid repeated freeze-thaw cycles.
• Storage Buffer: PBS

Gene Information

• Gene Name: TGFB3 transforming growth factor beta 3 [ Homo sapiens (human) ]
• Official Symbol: TGFB3
• Synonyms: TGFB3; transforming growth factor beta 3; ARVD; LDS5; RNHF; ARVD1; TGF-beta3; transforming growth factor beta-3 proprotein; prepro-transforming growth factor beta-3
• Gene ID: 7043
• mRNA Refseq: NM_003239
• Protein Refseq: NP_003230
• MIM: 190230
• UniProt ID: P10600