Active Recombinant Human TGFB3 Protein

• Cat.No.: TGFB3-018H
• Product Overview: Purified recombinant protein of Human transforming growth factor, beta 3 (TGFB3)(Ala301-Ser412) was expressed in CHO cells.

Specification

• Species: Human
• Source: CHO
• Tag: Non
• Protein Length: 301-412 a.a.
• Description: This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate a latency-associated peptide (LAP) and a mature peptide, and is found in either a latent form composed of a mature peptide homodimer, a LAP homodimer, and a latent TGF-beta binding protein, or in an active form consisting solely of the mature peptide homodimer. The mature peptide may also form heterodimers with other TGF-beta family members. This protein is involved in embryogenesis and cell differentiation, and may play a role in wound healing. Mutations in this gene are a cause of aortic aneurysms and dissections, as well as familial arrhythmogenic right ventricular dysplasia 1. [provided by RefSeq, Aug 2016].
• Bio-activity: The ED50 is from 0.10 to 0.4 ng/ml, corresponding to a specific activity of 2.5-10 x 10^6 units/mg.
• Molecular Mass: 12.7 kDa
• Endotoxin: Less than 0.01 ng per µg protein as determined by the LAL method.
• Purity: > 98% as determined by Coomassie stained SDS-PAGE.
• Concentration: Protein formulated and vialed at >50 µg/mL in specified buffer
• Storage Buffer: 25% Acetonitrile, 0.1% TFA (trifluoroacetic acid)

Gene Information

• Gene Name: TGFB3 transforming growth factor, beta 3 [ Homo sapiens ]
• Official Symbol: TGFB3
• Synonyms: TGFB3; transforming growth factor, beta 3; transforming growth factor beta-3; TGF-beta-3; ARVD; TGF-beta3; FLJ16571
• Gene ID: 7043
• mRNA Refseq: NM_003239
• Protein Refseq: NP_003230
• MIM: 190230
• UniProt ID: P10600