HDAC6

What is HDAC6 protein?

HDAC6 (histone deacetylase 6) gene is a protein coding gene which situated on the short arm of chromosome X at locus Xp11. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It contains an internal duplication of two catalytic domains which appear to function independently of each other. This protein possesses histone deacetylase activity and represses transcription. The protein consisted of 1215 amino acids and is approximately 131.4 kDa.

What is the Function of HDAC6 protein?

The protein HDAC6 is a cytoplasmic enzyme that regulates many key biological processes. These processes include cell migration, immune synapse formation, viral infection, and the degradation of misfolded proteins. In addition, HDAC6 deacetylates tubulin, Hsp90, and actin, and can form complexes with other protein companions. In particular, HDAC6 can specifically catalyze non-histone substrates and participate in and regulate numerous physiological or pathological processes. While HDAC6 is a central component of the stress response that regulates SG formation and potentially contributes to control of RNA metabolism and translation.

HDAC6 Related Signaling Pathway

HDAC6 can participate in the occurrence and development of tumor by activating Ras signaling pathway, influencing cell cycle, inhibiting apoptosis, regulating cellular immunity and promoting the invasion and metastasis of cancer cells. In addition, HDAC6 plays a key role in inducing epithelial mesenchymal transformation (EMT) in the TGF-β signaling pathway, which is a key step in many types of cancer.

HDAC6 Related Diseases

Mutations in the HDAC6 gene are commonly associated with cardiovascular and inflammatory diseases. More seriously, HDAC6 are associated with X-Linked Dominant Chondrodysplasia. In addition, mutations in the HDAC6 gene are also associated with the occurrence and development of neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease, breast cancer, colon cancer, lung cancer and many other cancers.

Fig1. Schematic model of HDAC6 regulating lung cancer cell growth.

Bioapplications of HDAC6

The modulation of HDAC6 activity holds potential for the development of novel therapeutic strategies across a range of diseases. HDAC6 inhibitors have shown promise in preclinical and clinical studies for the treatment of certain cancers, including multiple myeloma and lymphoma.

Case Study 1: Ji Hyeon Lee, 2022

Fig1. qRT-PCR data are representative of three independent experiments.

Case Study 2: Guangying Xu, 2022

Fig2. HDAC6 protein expression in colon cancer and M2 macrophage infiltration in the microenvironment were evaluated using an mIHC platform (panel: CK/HDAC6/CD68/CD163).

HDAC6 has several biochemical functions, for example, Hsp90 protein binding,NAD-dependent histone deacetylase activity (H3-K14 specific),actin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HDAC6 itself. We selected most functions HDAC6 had, and list some proteins which have the same functions with HDAC6. You can find most of the proteins on our site.

HDAC6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HDAC6 here. Most of them are supplied by our site. Hope this information will be useful for your research of HDAC6.

EGFR;UBC;CYLD;ADRBK1