Recombinant Human Histone Deacetylase 6, GST-tagged

• Cat.No.: HDAC6-402H
• Product Overview: RecombinantHuman HDAC6 protein was expressed as GST-tagged fusion protein by E. coli andpurified by GSH-sepharose.

Specification

• Cat. No.: HDAC6-402H
• Description: HDAC6is an enzyme that in humans is encoded by the HDAC6 gene. Histones play acritical role in transcriptional regulation, cell cycle progression, anddevelopmental events. It contains an internal duplication of two catalyticdomains which appear to function independently of each other.
• Source: E. coli
• Species: Human
• Antigen peptide: C-term-352aa
• Expression Vector: PGEX-4T
• Full length: False
• Reconstitution: 1M PBS (58mMNa2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% TritonX-100,15%glycerol.
• Storage: The protein is stored in PBS buffer at -20°C. Repeated freeze-thaw cycles should be avoided.

Gene Information

• Gene Name: HDAC6 histonedeacetylase 6 [ Homo sapiens ]
• Official Symbol: HDAC6
• Synonyms: HDAC6;histone deacetylase 6; HD6; JM21; FLJ16239; EC 3.5.1.98; KIAA0901;OTTHUMP00000032398; OTTHUMP00000197663
• Gene ID: 10013
• mRNA Refseq: NM_006044
• Protein Refseq: NP_006035
• MIM: 300272
• UniProt ID: Q9UBN7
• Chromosome Location: Xp11.23
• Pathway: Cell cycle; NOTCH1 Intracellular DomainRegulates Transcription; Signal Transduction; Signaling by NOTCH; Signalingby NOTCH1; Signaling events mediated by HDAC Class I; Signaling eventsmediated by HDAC Class II; TNF-alpha/NF-kB Signaling Pathway
• Function: Hsp90 protein binding; NAD-dependenthistone deacetylase activity (H3-K14 specific); NAD-dependent histonedeacetylase activity (H3-K9 specific); NAD-dependent histone deacetylaseactivity (H4-K16 specific); actin binding; alpha-tubulin binding; beta-cateninbinding; beta-tubulin binding; dynein complex binding; enzyme binding;histone deacetylase activity; histone deacetylase activity (H3-K16 specific);histone deacetylase binding; hydrolase activity; metal ion binding