Recombinant Human HDAC6 Protein, GST-tagged

• Cat.No.: HDAC6-096H
• Product Overview: Full-length recombinant N-terminal GST-tagged human HDAC6 protein was expressed in Sf9 cells.

Specification

• Description: Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It contains an internal duplication of two catalytic domains which appear to function independently of each other. This protein possesses histone deacetylase activity and represses transcription.
• Source: Insect cell
• Species: Human
• Tag: GST
• Molecular Mass: 159 kDa
• Purity: ≥65% estimated by SDS-PAGE
• Unit Definition: One unit is the amount of enzyme required to release 1 pmol of acetate per minute at 37 centigrade in 25 mM Tris/HCl, pH 8.0, 137 mM NaCl, 2.7 mM KCl, 1 mM MgCl2, 0.1 mg/ml BSA, and 20 μM fluorogenic HDAC substrate 3.
• Stability: ≥ 6 months
• Storage: At -80 centigrade.
• Storage Buffer: 40 mM Tris-HCl, pH 8.0, 110 mM sodium chloride, with 2.2 mM potassium chloride, 0.04% Tween 20, 3 mM DTT, and 20% glycerol

Gene Information

• Gene Name: HDAC6 histone deacetylase 6 [ Homo sapiens (human) ]
• Official Symbol: HDAC6
• Synonyms: HDAC6; histone deacetylase 6; HD6; JM21; CPBHM; PPP1R90; histone deacetylase 6; protein phosphatase 1, regulatory subunit 90; tubulin-lysine deacetylase HDAC6; EC 3.5.1.98
• Gene ID: 10013
• mRNA Refseq: NM_006044
• Protein Refseq: NP_006035
• MIM: 300272
• UniProt ID: Q9UBN7