Recombinant Human Histone Deacetylase 6, GST-tagged

• Cat.No.: HDAC6-399H
• Product Overview: HumanHDAC6 full-length ORF (1 a.a. - 1063 a.a.) recombinantprotein with GST-tag atN-terminal expressed in vitro wheat germ.

Specification

• Cat. No.: HDAC6-399H
• Description: HDAC6is an enzyme that in humans is encoded by the HDAC6 gene.
• Source: WheatGerm
• Species: Human
• Molecular Weight: 142.67kDa
• Reconstitution: 50 mMTris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
• Quality ControlTesting: 12.5%SDS-PAGE Stained with Coomassie Blue.
• Preparation Method: In vitrowheat germ expression system.
• Purification: GlutathioneSepharose 4 Fast Flow.
• Sequences of aminoacids: METTQYMNEG ELRVLADTYD SVYLHPNSYS CACLASGSVL RLVDAVLGAEIRNGMAIIRP PGHHAQHSLM DGYCMFNHVA VAARYAQQKH RIRRVLIVDW DVHHGQGTQF TFDQDPSVLYFSIHRYEQGR FWPHLKASNW STTGFGQGQG YTINVPWNQV GMRDADYIAA FLHVLLPVAL EFQPQLVLVAAGFDALQGDP KGEMAATPAG FAQLTHLLMG LAGGKLILSL EGGYNLRALA EGVSASLHTL LGDPCPMLESPGAPCRSAQA SVSCALEALE PFWEVLVRST ETVERDNMEE DNVEESEEEG PWEPPVLPIL TWPVLQSRTGLVYDQNMMNH CNLWDSHHPE VPQRILRIMC RLEELGLAGR CLTLTPRPAT EAELLTCHSA EYVGHLRATEKMKTRELHRE SSNFDSIYIC PSTFACAQLA TGAACRLVEA VLSGEVLNGA AVVRPPGHHA EQDAACGFCFFNSVAVAARH AQTISGHALR ILIVDWDVHH GNGTQHMFED DPSVLYVSLH RYDHGTFFPM GDEGASSQIGRAAGTGFTVN VAWNGPRMGD ADYLAAWHRL VLPIAYEFNP ELVLVSAGFD AARGDPLGGC QVSPEGYAHLTHLLMGLASG RIILILEGGY NLTSISESMA ACTRSLLGDP PPLLTLPRPP LSGALASITE TIQVHRRYWRSLRVMKVEDR EGPSSSKLVT KKAPQPAKPR LAERMTTREK KVLEAGMGKV TSASFGEEST PGQTNSETAVVALTQDQPSE AATGGATLAQ TISEAAIGGA MLGQTTSEEA VGGATPDQTT SEETVGGAIL DQTTSEDAVGGATLGQTTSE EAVGGATLAQ TTSEAAMEGA TLDQTTSEEA PGGTELIQTP LASSTDHQTP PTSPVQGTTPQISPSTLIGS LRTLELGSES QGASESQAPG EENLLGEAAG GQDMADSMLM QGSRGLTDQA IFYAVTPLPWCPHLVAVCPI PAAGLDVTQP CGDCGTIQEN WVCLSCYQVY CGRYINGHML QHHGNSGHPL VLSYIDLSAWCYYCQAYVHH QALLDVKNIA HQNKFGEDMP HPH
• Storage: Storeat -80°C. Aliquot to avoid repeated freezing and thawing.

Gene Information

• Gene Name: HDAC6 histonedeacetylase 6 [ Homo sapiens ]
• Official Symbol: HDAC6
• Synonyms: HDAC6;histone deacetylase 6; HD6; JM21; FLJ16239; EC 3.5.1.98; KIAA0901;OTTHUMP00000032398; OTTHUMP00000197663
• Gene ID: 10013
• mRNA Refseq: NM_006044
• Protein Refseq: NP_006035
• MIM: 300272
• UniProt ID: Q9UBN7
• Chromosome Location: Xp11.23
• Pathway: Cell cycle; NOTCH1 Intracellular DomainRegulates Transcription; Signal Transduction; Signaling by NOTCH; Signalingby NOTCH1; Signaling events mediated by HDAC Class I; Signaling eventsmediated by HDAC Class II; TNF-alpha/NF-kB Signaling Pathway
• Function: Hsp90 protein binding; NAD-dependenthistone deacetylase activity (H3-K14 specific); NAD-dependent histonedeacetylase activity (H3-K9 specific); NAD-dependent histone deacetylaseactivity (H4-K16 specific); actin binding; alpha-tubulin binding;beta-catenin binding; beta-tubulin binding; dynein complex binding; enzymebinding; histone deacetylase activity; histone deacetylase activity (H3-K16specific); histone deacetylase binding; hydrolase activity; metal ion binding