FCGR2B
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Official Full Name
Fc fragment of IgG, low affinity IIb, receptor (CD32) -
Overview
The protein encoded by this gene is a low affinity receptor for the Fc region of immunoglobulin gamma complexes. The encoded protein is involved in the phagocytosis of immune complexes and in the regulation of antibody production by B-cells. Variations in this gene may increase susceptibilty to systemic lupus erythematosus (SLE). Several transcript variants encoding different isoforms have been found for this gene. -
Synonyms
FCGR2B;Fc fragment of IgG, low affinity IIb, receptor (CD32);CD32;FCG2;CD32B;FCGR2;IGFR2;low affinity immunoglobulin gamma Fc region receptor II-b;CDw32;fcRII-b;Fc gamma RIIb;fc-gamma-RIIb;fc-gamma RII-b;igG Fc receptor II-b;Fc fragment of IgG, low affinity II, receptor for (CD32);Fc fragment of IgG, low affinity IIb, receptor for (CD32)
Recombinant Proteins
- Human
- Mouse
- Rat
- Cynomolgus
- Rhesus macaque
- E.coli
- Human Cell
- HEK293
- Mammalian cells
- Mammalian Cell
- Wheat Germ
- CHO Cells
- CHO
- HEK293T
- In Vitro Cell Free System
- E.coli expression system
- GST
- His&Avi
- His
- C-His&Avi
- Non
- His&T7
- Myc&DDK
- Flag
- His&Fc&Avi
Involved Pathway
FCGR2B involved in several pathways and played different roles in them. We selected most pathways FCGR2B participated on our site, such as Phagosome,Osteoclast differentiation,B cell receptor signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with FCGR2B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Staphylococcus aureus infection | FPR3,HLA-DPA1,C5AR1,FGG,HLA-DRB1,PLG,C4A,MASP1,C1RA,C1QA |
| Measles | HSPA1L,IFNA17,TNFRSF10D,IL12B,IFNA6,STAT2,HSPA6,MAVS,PIK3CB,TNFSF10 |
| Fc gamma R-mediated phagocytosis | GAB2,PPAP2B,ASAP3,INPPL1,RAC1,LIMK2,WASL,HCK,PLD2,CFL1 |
| B Cell Receptor Signaling Pathway | BCL10,MALT1,CDK2,CRKL,NFKBIB,RAC1,PPP3CA,CR2,PIK3CD,PRKCB |
| Phagosome | MHC2DEB,CORO1A,NCF2,FCGR2A,ATP6V1B2,LAMP1,STX12,BLA,HLA-C,TUBA3A |
| Tuberculosis | IRAK1,IL10RB,IFNA4,HLA-DRB1,STAT1,LAMP2,BAX,ATP6V0B,HLA-DMA,H2-AA |
| Osteoclast differentiation | TGFBR2,OSCAR,IKBKG,TRAF2,RAC1,PIK3CG,MITF,CYBA,LILRB3,SIRP-BETA |
Protein Function
FCGR2B has several biochemical functions, for example, IgG binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FCGR2B itself. We selected most functions FCGR2B had, and list some proteins which have the same functions with FCGR2B. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| IgG binding | PIP,FCGR1A,FCGR1B,FCER1G,FCGR2C,cgr2b,FCGRT,FCGR2A,CD247L,FCGR3A |
| protein binding | KLF6,BLK,CLCN1,PRSS21,PFKM,HMG20B,ATF2,UBASH3A,NFE2L3,ACKR4 |
Interacting Protein
FCGR2B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FCGR2B here. Most of them are supplied by our site. Hope this information will be useful for your research of FCGR2B.
PTPN6;IGHG1
Resources
Research Area
Fc ReceptorsITIM/ITAM Immunoreceptors and Related Molecules
B Cell CD Antigen
Granulocyte Markers
CD Antigen (Dendritic Cell Pathogen Recognition Uptake)
CD Antigen (Granulocyte Markers)
Macrophage Marker CD Antigen
Macrophage Markers
Thymus-Independent B Cell Activation
Dendritic Cell Pathogen Recognition/Uptake
MDSC Phenotyping - Positive Markers
Related Services
Related Products
References
- Karpus, ON; Kiener, HP; et al. CD55 deposited on synovial collagen fibers protects from immune complex-mediated arthritis. ARTHRITIS RESEARCH & THERAPY 17:-(2015).
- Lee, CS; Ashton-Key, M; et al. Expression of the inhibitory Fc gamma receptor IIB (FCGR2B, CD32B) on follicular lymphoma cells lowers the response rate to rituximab monotherapy (SAKK 35/98). BRITISH JOURNAL OF HAEMATOLOGY 168:145-148(2015).
