Efnb2
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Official Full Name
Ephrin-B2 -
Overview
Ephrin type-B receptor 2 is a protein that in humans is encoded by the EPHB2 gene. Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by this gene is a receptor for ephrin-B family members. -
Synonyms
EPHB2;EPH receptor B2;DRT;EK5;ERK;CAPB;Hek5;PCBC;EPHT3;Tyro5;MGC87492;ephrin type-B receptor 2;EPH-like kinase 5;eph tyrosine kinase 3;elk-related tyrosine kinase;protein-tyrosine kinase HEK5;tyrosine-protein kinase TYRO5;renal carcinoma antigen NY-REN-47;tyrosine-protein kinase receptor EPH-3;developmentally-regulated Eph-related tyrosine kinase;EphB2;EC=2.7.10.1;Developmentally-regulated Eph-related tyrosine kinase;CAPB;PCBC;EFN B2;EFNB 2;EFNB2;Eph related receptor tyrosine kinase ligand 5;EPH-related receptor tyrosine kinase ligand 5;Ephrin-B2;EphrinB2;EPLG 5;EPLG5;Htk L;HTK ligand;HTK-L;HTKL;LERK 5;LERK-5;LERK5;Ligand of eph related kinase 5 antibody;MGC126226;MGC126227;MGC126228;OTTMUSP00000024973;Htk-L;ELF-2;NLERK-1
Recombinant Proteins
- Human
- Mouse
- Rat
- Canine
- Chicken
- Mus musculus
- HEK293
- Mammalian Cells
- E.coli
- Human Cells
- Wheat Germ
- Insect Cells
- In Vitro Cell Free System
- Fc
- His
- Fc&His
- GST&His
- GST
- Non
- Avi&Fc&His
- DDK&Myc
Involved Pathway
Efnb2 involved in several pathways and played different roles in them. We selected most pathways Efnb2 participated on our site, such as Axon guidance,Developmental Biology,EPH-Ephrin signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with Efnb2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| EPHB-mediated forward signaling | ARPC2,ARPC1B,KALRNB,ARHGEF28,ARPC3,ACTR2B,EPHB4A,EPHB4B,EFNB2A,KALRN |
| Developmental Biology | CNKSR1,RNF8,FGFR1B,GDNF,FRS2A,JAK1,RND1L,ST8SIA2,PRDM14,PAK4 |
| EPH-ephrin mediated repulsion of cells | EFNA1,EFNA4,EPHA4A,EPHB3A,EPHA2A,EFNA5,EFNA3,EFNB3B,AP2B1,EFNB1 |
| EPHB forward signaling | EFNB3,EFNB1,ITSN1,GRB7,EFNA5 |
| Axon guidance | EFNA2,MAPK3,EFNA3B,EPHA5,FES,ARHGEF12,SCN9A,JAK1,Sema3f,NRG4 |
| EPH-Ephrin signaling | EFNA1,EPHA2A,AP2M1,AP2A2,ARHGEF28,KALRN,EPHB4A,EPHA10,EFNB2A,AP2B1 |
| Ephrin signaling | EFNB2A,EPHB3A,EPHB4A,EFNB3B,SDCBP,MYL12A,EFNB3,EFNB1,EPHB4B |
| Ephrin B reverse signaling | PTPN13,EFNB1 |
Protein Function
Efnb2 has several biochemical functions, for example, ephrin receptor binding,protein binding,virus receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Efnb2 itself. We selected most functions Efnb2 had, and list some proteins which have the same functions with Efnb2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | FAM86A,KCTD15,IGF2BP2,THOC1,TRIM32,CARD8,SPI1B,HRAS,TERF2IP,WNT2 |
| ephrin receptor binding | EFNA2,CHN1,EFNA3B,SRC,EFNA1B,PTPN1,EFNA5,CRK,EFNB3B,EFNB2B |
| virus receptor activity | SLC1A5,SLC20A2,CLEC4M,CD46,CR2,TYRO3,ACE2,CR1,SELPLG,ITGB6 |
Interacting Protein
Efnb2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Efnb2 here. Most of them are supplied by our site. Hope this information will be useful for your research of Efnb2.
NCK2
Resources
Research Area
Endothelial Cell Development MoleculesSynaptic Adhesion Molecules
Glial Lineage Markers
Ephrin
Related Services
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References
