Recombinant Mouse Ephrin B2, Fc-His

• Cat.No.: Efnb2-1734M
• Product Overview: Recombinant Mouse EphrinB2 (Arg27-Ala227) produced inNSO Cellswas fused to Fc region of human IgG1 (Pro100 - Lys330) - 6xHis tag

Specification

• Cat. No.: Efnb2-1734M
• Description: Ephrin-B2 (EFNB2) is a transmembrane ligand that is specifically expressed on arterial endothelial cells (ECs) and surrounding cells and interacts with multiple EphB class receptors. Ephrin-B2 plays a role in angiogenesis and regulates the targeted migration of branchial neural crest cells. EFNB2 serves as a functional receptor for both Hendra virus (HeV) and Nipah virus (NiV).
• Molecular Weight: The predicted molecular weight of Recombinant Mouse Ephrin-B2 is Mr 49.6 kDa. However, the actual molecular weight as observed by migration on SDS Page is Mr 60-65 kDa.
• Source: Mammalian cells
• State Of Matter: Lyophilized.
• Purity: >90% by SDS Page and analyzed by silver stain.
• Formulation: This recombinant protein was 0.2 µm filtered and lyophilized from modified Dulbecco's phosphate buffered saline (1X PBS) pH 7.2 – 7.3 with no calcium, magnesium, or preservatives.
• Endotoxin: <1.0 EU/µg as determined by the LAL method.
• Biological Activity: The biological activity of Mouse EFNB2 was determined by its ability to compete with biotinylated rmEphrinB2 for binding with immobilized rmEphB2 in a functional ELISA assay.
• Storage And Stability: This lyophilized protein is stable for six to twelve months when stored desiccated at -20℃ to -70℃. After aseptic reconstitution, this protein may be stored at 2℃ to 8℃ for one month or at -20℃ to -70℃ in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
• Tag: His&Fc
• Protein length: Arg27-Ala227

Gene Information

• Gene Name: Efnb2 ephrin B2 [ Mus musculus ]
• Synonyms: Efnb2; ephrin B2; Epl5; ELF-2; Eplg5; Htk-L; Lerk5; LERK-5; NLERK-1; OTTMUSP00000024973
• Gene ID: 13642
• mRNA Refseq: NM_010111
• Protein Refseq: NP_034241
• UniProt ID: P52800
• Chromosome Location: 8 A1.1; 8 2.0 cM
• Pathway: Axon guidance
• Function: receptor binding

Reviews

01/05/2022

During the experiment, the technician helped me solve the problems in a timely and accurate manner.

01/02/2022

The EFNB2 proteins purchased from your company is suitable for WB.

01/23/2021

Received high quality protein products and obtained satisfactory experimental results.

Q&As

What effect does EphB6 overexpression have on EFNB2?

EphB6 overexpression up-regulates the expression of its ligand EFNB2.

What diseases is EFNB2 involved in?

EFNB2 is associated with breast, colon, bladder, cervical and other cancers.

What is the biological function of EFNB2?

EFNB2 is involved in tissue plasticity, tumorigenesis, and other biological processes.

Where is EFNB2 mainly expressed?

EFNB2 is widely expressed in tumor vasculature.

What is the association between EFNB2 and BUC cells?

EFNB2 promotes BUC cell proliferation by inhibiting apoptosis in BUC cells.

How is EphB6 related to EFNB2?

EFNB2 is one of the physiological ligands of EphB6 that functions by binding to EphB6.