Recombinant Mouse Efnb2 Protein, Myc/DDK-tagged

• Cat.No.: Efnb2-2756M
• Product Overview: Purified recombinant protein of mouse full-length ephrin B2 (Efnb2), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds to receptor tyrosine kinase including EPHA4, EPHA3 and EPHB4. Together with EPHB4 plays a central role in heart morphogenesis and angiogenesis through regulation of cell adhesion and cell migration. EPHB4-mediated forward signaling controls cellular repulsion and segregation from EFNB2-expressing cells. May play a role in constraining the orientation of longitudinally projecting axons.
• Source: HEK293T
• Species: Mouse
• Tag: Myc&DDK
• Molecular Mass: 37.2 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Efnb2 ephrin B2 [ Mus musculus (house mouse) ]
• Official Symbol: Efnb2
• Synonyms: EFNB2; ephrin B2; ephrin-B2; HTK ligand; EPH-related receptor tyrosine kinase ligand 5; Epl5; ELF-2; Eplg5; Htk-L; Lerk5; LERK-5; NLERK-1
• Gene ID: 13642
• mRNA Refseq: NM_010111
• Protein Refseq: NP_034241
• UniProt ID: P52800