Angpt2

  • Official Full Name

    angiopoietin 2

  • Overview

    The protein encoded by this gene is an antagonist of angiopoietin 1 (ANGPT1) and endothelial TEK tyrosine kinase (TIE-2, TEK). The encoded protein disrupts the vascular remodeling ability of ANGPT1 and may induce endothelial cell apoptosis. Three transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

  • Synonyms

    ANGPT2;angiopoietin 2;ANG2;AGPT2;angiopoietin-2;ANG-2;Tie2-ligand;angiopoietin-2B;angiopoietin-2a

Recombinant Proteins

  • Mouse
  • Cynomolgus
  • Human
  • Pig
  • Cynomolgus/Rhesus
  • Dog
  • Canine
  • Cattle
  • Rat
  • Rabbit
  • Chicken
  • Cynomolgus/Rhesus macaque
  • Rhesus macaque
  • CHO
  • HEK293
  • E.coli
  • Mammalian cell
  • Mammalian cells
  • Hamster
  • Insect Cell
  • Wheat Germ
  • Yeast
  • Mammalian Cell
  • Human Cell
  • In Vitro Cell Free System
  • C-His
  • CHO Stable Cells
  • Insect Cells
  • His
  • Fc
  • GST
  • Flag
  • Non
  • Myc
  • His&T7
  • mIgG2a
  • His&Fc&Avi
  • FLAG
  • N-His-Avi
  • His&Avi
Cat.# Product name Source (Host) Species Tag Protein Length Price
Angpt2-2163M Active Recombinant Mouse Angpt2 Protein, C-6×His tagged CHO Mouse His
ANGPT2-1173C Active Recombinant Cynomolgus ANGPT2 Protein, His-tagged HEK293 Cynomolgus His 1-495 a.a.
ANGPT2-200H Active Recombinant Human ANGPT2 protein, hFc-tagged HEK293 Human Fc Met1-Phe496
ANGPT2-3182H Active Recombinant Human ANGPT2 protein(Met1-Phe496), His-tagged HEK293 Human His Met1-Phe496
ANGPT2-9645H Recombinant Human ANGPT2, GST-tagged E.coli Human GST 357-443a.a.
ANGPT2-01P Recombinant Pig ANGPT2 Protein, N-His tagged Mammalian cell Pig His
ANGPT2-3075H Recombinant Human ANGPT2 protein, His-tagged E.coli Human His 174-318 aa
ANGPT2-696H Recombinant Human ANGPT2 Protein, His-tagged CHO Human His 19-496 aa
ANGPT2-1172C Active Recombinant Cynomolgus/Rhesus ANGPT2 protein, hFc-tagged HEK293 Cynomolgus/Rhesus Fc Lys274-Phe495
ANGPT2-158H Active Recombinant Human ANGPT2 Protein, His-tagged, Biotinylated Mammalian cells Human His Tyr19-Phe496
ANGPT2-435H Active Recombinant Human ANGPT2, Flag-tagged HEK293 Human Flag 19-496 a.a.
ANGPT2-550H Active Recombinant Human ANGPT2 protein, His-tagged Hamster Human His
Angpt2-587M Active Recombinant Mouse Angpt2 Protein, His-tagged CHO Mouse His Met1-Phe496
ANGPT2-933H Active Recombinant Human ANGPT2 Protein, His-tagged Mammalian cells Human His Tyr19-Phe496
ANGPT2-934H Active Recombinant Human ANGPT2 Protein, His-tagged Protein, Biotinylated Mammalian cells Human His Tyr19-Phe496
ANGPT2-2167C Active Recombinant Cynomolgus/Rhesus ANGPT2 protein, His-tagged HEK293 Cynomolgus/Rhesus His Lys274-Phe495
ANGPT2-2938D Recombinant Dog ANGPT2 protein(19-495aa), His-tagged HEK293 Dog His 19-495aa
Angpt2-476M Active Recombinant Mouse Angpt2 protein, His-tagged HEK293 Mouse His Tyr 19 - Phe 496
Ang-2-3456H Recombinant Human Ang-2 CHO Human Non 655
ANGPT2-1040C Active Recombinant Canine ANGPT2 protein(Lys274-Phe495), His-tagged HEK293 Canine His Lys274-Phe495
ANGPT2-116H Recombinant Human Angiopoietin 2, Myc-tagged Insect Cell Human Myc 21-496 a.a.
ANGPT2-244H Active Recombinant Human ANGPT2 protein, His-tagged HEK293 Human His Lys275-Phe496
ANGPT2-269H Recombinant Human ANGPT2, His-tagged, Biotinylated HEK293 Human His 19-496 a.a.
ANGPT2-388H Recombinant Human ANGPT2 Protein, His-tagged CHO Human His
Angpt2-475M Recombinant Mouse ANGPT2 protein(Lys275-Phe496), His-tagged HEK293 Mouse His Lys275-Phe496
ANGPT2-530C Recombinant Cattle ANGPT2 protein, His-tagged E.coli Cattle His Gln1~Pro123
ANGPT2-531H Recombinant Human ANGPT2 protein, His-tagged E.coli Human His Lys24~Leu165
ANGPT2-532H Recombinant Human ANGPT2 protein, His-tagged E.coli Human His Lys269~Phe496
Angpt2-533M Recombinant Mouse Angpt2 protein, His-tagged E.coli Mouse His Tyr19~Ala147
ANGPT2-534P Recombinant Pig ANGPT2 protein, His & T7-tagged E.coli Pig His&T7 Asn89~Leu206
Angpt2-535R Recombinant Rat Angpt2 protein, His-tagged E.coli Rat His Gln33~Val243
Angpt2-536R Recombinant Rat Angpt2 protein, His-tagged E.coli Rat His Glu352~Trp477
ANGPT2-537R Recombinant Rabbit ANGPT2 protein, His-tagged E.coli Rabbit His Leu230~Thr487
ANGPT2-551H Recombinant Human ANGPT2 protein, GST-tagged Wheat Germ Human GST
ANGPT2-55H Recombinant Human ANGPT2 Yeast Human Non
ANGPT2-6380C Recombinant Chicken ANGPT2 Mammalian Cell Chicken His
ANGPT2-669R Active Recombinant Rat ANGPT2 protein, His-tagged HEK293 Rat His Lys 275 - Phe 496
Angpt2-88M Recombinant Mouse Angpt2, FLAG-tagged HEK293 Mouse Flag 19-496 a.a.
ANGPT2-001MCL Recombinant Mouse ANGPT2 cell lysate Human Cell Mouse Non
ANGPT2-2228HCL Recombinant Human ANGPT2 cell lysate Human Cell Human Non
ANGPT2-013H Recombinant Human ANGPT2 Protein, TYR19-PHE496, Tag Free, Biotinylated HEK293 Human Non TYR19-PHE496
ANGPT2-0476H Recombinant Human ANGPT2 Protein (Lys24-Leu165), His-tagged E.coli Human His Lys24-Leu165
ANGPT2-1034HF Recombinant Full Length Human ANGPT2 Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 496 amino acids
ANGPT2-1067H Recombinant Human ANGPT2 Protein (Met1-Gln248 and Lys275-Phe496), MlgG2a Fc-tagged HEK293 Human mIgG2a Met1-Gln248 and Lys275-Phe496
ANGPT2-1174C Recombinant Cynomolgus/Rhesus ANGPT2 protein (Met1-Phe495), His-tagged HEK293 Cynomolgus/Rhesus macaque His 1-495 a.a.
ANGPT2-1175C Recombinant Rhesus Macaque ANGPT2(Tyr19-Phe495) Protein, C-Fc-tagged HEK293 Rhesus macaque Fc 19-495 a.a.
ANGPT2-152H Recombinant Human ANGPT2 Protein, His-tagged E.coli Human His Lys24-Phe496
ANGPT2-1666M Recombinant Mouse ANGPT2 protein, His-tagged C-His Mouse Lys275-Phe496
ANGPT2-245H Recombinant Human ANGPT2(Lys275-Phe496) Protein, C-6*His-tagged HEK293 Human His 275-496 a.a.
ANGPT2-2467H Recombinant Human ANGPT2 Protein, His (Fc)-Avi-tagged HEK293 Human His&Fc&Avi
ANGPT2-2467H-B Recombinant Human ANGPT2 Protein Pre-coupled Magnetic Beads HEK293 Human
ANGPT2-2711H Recombinant Human ANGPT2 Protein (Met1-Phe496), C-His tagged Mammalian cells Human His Met1-Phe496
ANGPT2-27R Recombinant Rabbit ANGPT2 Protein (19-496), C-6×His-tagged HEK293 Rabbit His 19-496
ANGPT2-2888H Recombinant Human ANGPT2 protein, His-tagged, FITC-Labeled HEK293 Human His Lys 275-Phe 496
ANGPT2-28P Recombinant Pig ANGPT2 Protein, His tagged HEK293 Pig His
ANGPT2-315R Active Recombinant Rabbit ANGPT2 protein, His-tagged HEK293 Rabbit His Lys 275 - Phe 496
ANGPT2-325R Recombinant Rat ANGPT2 Protein, His (Fc)-Avi-tagged HEK293 Rat His&Fc&Avi
ANGPT2-325R-B Recombinant Rat ANGPT2 Protein Pre-coupled Magnetic Beads HEK293 Rat
ANGPT2-34H Recombinant Human ANGPT2 Protein, N-FLAG-tagged HEK293 Human FLAG 28-72;258-496 a.a.
ANGPT2-415H Active Recombinant Human ANGPT2 Protein (Met1-Phe496), His-tagged CHO Human His Met1-Phe496
ANGPT2-415HB Recombinant Human ANGPT2 protein, His-tagged, Biotinylated CHO Stable Cells Human His 1-496 a.a.
Angpt2-477M Recombinant Mouse Angpt2(Tyr19-Phe496) Protein, C-Fc-tagged HEK293 Mouse Fc 19-496 a.a.
ANGPT2-484H Recombinant Human ANGPT2 Protein Human 496
Angpt2-5135R Recombinant Rat Angpt2 protein(19-496aa), His-tagged E.coli Rat His 19-496aa
ANGPT2-5226H Recombinant Human ANGPT2 protein, His-tagged E.coli Human His 19-485aa
ANGPT2-523HB Recombinant Human ANGPT2 protein, His-Avi-tagged, Biotinylated HEK293 Human N-His-Avi Lys275-Phe496
ANGPT2-524HB Active Recombinant Human ANGPT2 protein, His & Avi-tagged, Biotinylated HEK293 Human His&Avi Lys275-Phe496
Angpt2-5309M Recombinant Mouse Angpt2 protein, His-tagged E.coli Mouse His 19-483aa
ANGPT2-5342H Recombinant Human ANGPT2 protein, His-tagged Yeast Human His 19-485aa
ANGPT2-6523H Recombinant Human ANGPT2 protein, His-Avi-tagged HEK293 Human N-His-Avi Lys275-Phe496
Angpt2-6543R Recombinant Rat Angpt2 protein(19-496aa), His-tagged Insect Cells Rat His 19-496aa
ANGPT2-6743M Active ANGPT2 protein-coupled magnetic Beads HEK293 Human Lys 275 - Phe 496
ANGPT2-964D Recombinant Dog ANGPT2 protein(19-495aa), His-tagged E.coli Dog His 19-495aa

    Involved Pathway

    Angpt2 involved in several pathways and played different roles in them. We selected most pathways Angpt2 participated on our site, such as Ras signaling pathway,Rap signaling pathway,HIF- signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with Angpt2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Ras signaling pathway REL,FGF10,PLA2G12B,FASLG,GNG12,Kitl,RASA4,PDGFB,GRIN2B,RASGRP3
    HIF- signaling pathway HKDC1,MTOR,PIK3CB,PGK1,FLT1,ANGPT4,HK3,PDHA1,EIF4E1B,IL6
    Rap signaling pathway KRIT1,GNAI2,ITGB1,MAPK3,INS,MET,MAP2K6,PDGFD,PIK3CG,INS1
    PIK-Akt signaling pathway TSC1,PGF,INS,FGF19,IFNA5,RPS6KB2,PPP2R5A,FGF11,CCND2,COL6A5

    Protein Function

    Angpt2 has several biochemical functions, for example, metal ion binding,protein binding,receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Angpt2 itself. We selected most functions Angpt2 had, and list some proteins which have the same functions with Angpt2. You can find most of the proteins on our site.

    Function Related Protein
    protein binding EIF4G1,STAMBP,Icosl,CT45A3,PSMB7,C9orf24,RASSF2,CA1,BIK,ERCC1
    receptor tyrosine kinase binding ZFP259,ELMO2,FNTA,ANGPT4,HYAL2,NRG3,FIZ1,PTPN1,DNAJA3,SHC4
    metal ion binding MCM10,NUDT8,ZDHHC16B,ZNF592,ZNF549,OSR1,ZNF691,CYP2D9,CA15A,MORC2A
    receptor binding SLC9A3R1,PCSK1N,TENM2,HSD17B4,LYN,TMED1,IAPP,LRP6,INHA,PTK2BB

    Interacting Protein

    Angpt2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Angpt2 here. Most of them are supplied by our site. Hope this information will be useful for your research of Angpt2.

    daap-5;TEK;daap-4;VEGFA;ANXA7;CDKN1A;CSNK2B;IQCB1

    Resources

    Research Area

    Cancer Drug Targets
    Angiogenesis Inhibitor
    Inflammatory Mediators
    Angiopoietins, Angiopoietin-like Proteins, and Receptors
    Angiopoietin
    Angiogenesis Inhibitor in Cancer

    References

    • Rigamonti, N; Kadioglu, E; et al. Role of Angiopoietin-2 in Adaptive Tumor Resistance to VEGF Signaling Blockade. CELL REPORTS 8:696-706(2014).
    • D'Amico, G; Korhonen, EA; et al. Tie1 deletion inhibits tumor growth and improves angiopoietin antagonist therapy. JOURNAL OF CLINICAL INVESTIGATION 124:824-834(2014).

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