Recombinant Human TIMP Metallopeptidase Inhibitor 1

• Cat.No.: TIMP1-2530H

Specification

• Species: Human
• Source: CHO
• Tag: Non
• Description: Tissue Inhibitor of Metalloproteinases 1, also known as TIMP1 is a widely expressed, secreted protein that functions primarily to inhibit members of a large family of metalloproteinases (MPs). Because of the ability of TIMP-1 to inhibit MPs, it functions in many of the same pathophysiological processes as these enzymes, e.g. wound healing, ovulation, angiogenesis, and cancer cell metastasis. TIMP-1 can also stimulate proliferation and cellular anabolic processes. TIMP-1 is a novel negative regulator of HGF activity during liver regeneration. Overexpression of TIMP-1 could promote renal interstitial fibrosis through the inflammatory pathway, which might be partly induced by upregulating ICAM-1.
• Biochem/physiol Actions: TIMP-1 has greater binding efficiency to MMP-9, MMP-1, and MMP-3 than the other MMPs.
• Physical Form: Supplied in 0.01 M sodium phosphate buffer pH 7.3, 0.15 M NaCl.
• Concentration: ~500 μg/mL protein.
• Form: buffered aqueous solution.
• Mol Wt: mol wt ~29 kDa.
• Storage Temp: −20°C.

Gene Information

• Gene Name: TIMP1 TIMP metallopeptidase inhibitor 1 [ Homo sapiens ]
• Synonyms: TIMP1; TIMP metallopeptidase inhibitor 1; EPA; EPO; HCI; CLGI; TIMP; FLJ90373; tissue inhibitor of metalloproteinase 1; erythroid potentiating activity; fibroblast collagenase inhibitor; tissue inhibitor of metalloproteinase 1 (erythroid potentiating activity, collagenase inhibitor); Tissue inhibitor of metalloproteinases; TIMP-1; Collagenase inhibitor; OTTHUMP00000023214; Erythroid-potentiating activity
• Gene ID: 7076
• mRNA Refseq: NM_003254
• Protein Refseq: NP_003245
• MIM: 305370
• UniProt ID: P01033
• Chromosome Location: Xp11.3-p11.23
• Function: enzyme inhibitor activity; metalloendopeptidase inhibitor activity; protein binding