Recombinant Human TIMP Metallopeptidase Inhibitor 1

• Cat.No.: TIMP1-5140H
• Product Overview: Recombinant human TIMP1was expressed in E. coli and purified by using SDS PAGE and HPLC.

Specification

• Species: Human
• Source: Human
• Tag: Non
• Description: TIMP1 is anextracellular inhibitor of MMPs (see above) including MMP1, 2, 3, 7, 8, 9,10, 11, 12, 13, and 16. It belongs to the I35 (TIMP) family of irreversibleprotease inhibitors that function as key modulators of extracellular matrixdegradation during tissue development and remodeling. TIMP1 can also actthrough an MMP-independent mechanism to promote erythropoiesis by stimulatingproliferation and differentiation of erythroid progenitors.
• Form: Suppliedas a lyophilized powder.
• Purity: >95% pure by SDSPAGE and HPLC
• Sequence: Region of TIMP1protein corresponding to amino acids CTCVPPHPQT AFCNSDLVIR AKFVGTPEVNQTTLYQRYEI KMTKMYKGFQ ALGDAADIRF VYTPAMESVC GYFHRSHNRS EEFLIAGKLQ DGLLHITTCSFVAPWNSLSL AQRRGFTKTY TVGCEECTVF PCLSIPCKLQ SGTHCLWTDQ LLQGSEKGFQ SRHLACLPREPGLCTWQSLR SQIA
• Molecular Mass: 20.6 kDa
• Applications: Numerousapplications are possible with this product and should be tested by the enduser under their own laboratory conditions.
• Storage: Storeat 4 deg C until reconstitution. Following reconstitution aliquot and freezeat -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.
• OfficialSymbol: TIMP1

Gene Information

• Gene Name: TIMP1TIMP metallopeptidase inhibitor 1 [ Homo sapiens ]
• Synonyms: TIMP1; TIMP metallopeptidase inhibitor 1; EPA; EPO; HCI; CLGI;TIMP; FLJ90373; metalloproteinase inhibitor 1; TIMP-1; OTTHUMP00000023214;OTTHUMP00000023216; collagenase inhibitor; erythroid potentiating activity;erythroid-potentiating activity; fibroblast collagenase inhibitor; tissueinhibitor of metalloproteinases 1; tissue inhibitor of metalloproteinase 1(erythroid potentiating activity,collagenase inhibitor); Erythroid-potentiatingactivity; Tissue inhibitor of metalloproteinases 1
• Gene ID: 7076
• mRNA Refseq: NM_003254
• Protein Refseq: NP_003245
• MIM: 305370
• UniProt ID: P01033
• Chromosome Location: Xp11.3-p11.23
• Pathway: Formationof Platelet plug; Hemostasis; IL6-mediated signaling events; MatrixMetalloproteinases; Platelet Activation; Platelet degranulation; Response toelevated platelet cytosolic Ca2+
• Function: enzymeinhibitor activity; metal ion binding; metalloendopeptidase inhibitoractivity; protein binding