Recombinant Human DOCK1 Protein, His-tagged

• Cat.No.: DOCK1-401H
• Product Overview: Recombinant Human DOCK1(Thr1200~Gln1435) fused with His tag at N-terminal was expressed in E. coli.

Specification

• Description: This gene encodes a member of the dedicator of cytokinesis protein family. Dedicator of cytokinesis proteins act as guanine nucleotide exchange factors for small Rho family G proteins. The encoded protein regulates the small GTPase Rac, thereby influencing several biological processes, including phagocytosis and cell migration. Overexpression of this gene has also been associated with certain cancers. Alternative splicing results in multiple transcript variants.
• Source: E. coli
• Species: Human
• Tag: His
• Form: PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
• Molecular Mass: 31.9kDa
• Protein length: Thr1200~Gln1435
• Endotoxin: <1.0EU per 1µg (determined by the LAL method)
• Purity: > 98%
• Applications: Positive Control; Immunogen; SDS-PAGE; WB.
  If bio-activity of the protein is needed, please check active protein.
• Stability: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 centigrade for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
• Storage: Avoid repeated freeze/thaw cycles. Store at 2-8 centigrade for one month. Aliquot and store at -80 centigrade for 12 months.
• Reconstitution: Reconstitute in PBS or others.

Gene Information

• Gene Name: DOCK1 dedicator of cytokinesis 1 [ Homo sapiens ]
• Official Symbol: DOCK1
• Synonyms: DOCK1; dedicator of cytokinesis 1; dedicator of cyto kinesis 1; dedicator of cytokinesis protein 1; ced5; DOCK180; DOwnstream of CrK; dedicator of cyto-kinesis 1; 180 kDa protein downstream of CRK
• Gene ID: 1793
• mRNA Refseq: NM_001380
• Protein Refseq: NP_001371
• MIM: 601403
• UniProt ID: Q14185