DOCK1
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Official Full Name
dedicator of cytokinesis 1 -
Overview
DOCK180 and its partner, ELMO1, interact directly with one another to form an atypical two-part guanine nucleotide exchange factor (GEF) for the small GTPase Rac (1). Rac activation occurs in association with p130 Cas and Crk, which form a complex with DO -
Synonyms
DOCK1;dedicator of cytokinesis 1;dedicator of cyto kinesis 1;dedicator of cytokinesis protein 1;ced5;DOCK180;DOwnstream of CrK;dedicator of cyto-kinesis 1;180 kDa protein downstream of CRK
Recombinant Proteins
- Human
- Zebrafish
- E.coli
- Wheat Germ
- Mammalian Cell
- In Vitro Cell Free System
- His
- Non
- GST
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| DOCK1-2543H | Recombinant Human DOCK1 protein, His-tagged | E.coli | Human | His | 1565-1865 aa | |
| DOCK1-401H | Recombinant Human DOCK1 Protein, His-tagged | E.coli | Human | His | Thr1200~Gln1435 | |
| DOCK1-26153TH | Recombinant Human DOCK1 | Wheat Germ | Human | Non | 152 amino acids |
|
| DOCK1-26951TH | Recombinant Human DOCK1 | Wheat Germ | Human | Non | 106 amino acids |
|
| DOCK1-2802H | Recombinant Human DOCK1 Protein, GST-tagged | Wheat Germ | Human | GST |
|
|
| DOCK1-6085Z | Recombinant Zebrafish DOCK1 | Mammalian Cell | Zebrafish | His |
|
|
| DOCK1-126HF | Recombinant Full Length Human DOCK1 Protein | In Vitro Cell Free System | Human | Full L. 152 amino acids |
|
|
| DOCK1-1980H | Recombinant Human DOCK1 Protein (Arg443-Cys627), N-His tagged | E.coli | Human | His | Arg443-Cys627 |
|
| DOCK1-4068HF | Recombinant Full Length Human DOCK1 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 152 amino acids |
|
Involved Pathway
DOCK1 involved in several pathways and played different roles in them. We selected most pathways DOCK1 participated on our site, such as Axon guidance,Bacterial invasion of epithelial cells,DCC mediated attractive signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with DOCK1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Focal adhesion | COL6A3,ACTG1,SHC3,MLCK2,BCL2,MYL12.2,GRB2B,PTK6,CAV1,PDGFD |
| DCC mediated attractive signaling | NTN1B,NTN1A,DCC,TRIO |
| Developmental Biology | PHB,NTN1A,MED25,CARM1,AP2B1,DUSP4,DCX,MYL9,KALRN,SCN8A |
| Axon guidance | DUSP9,SEMA7A,FGF20A,ARPC1B,CSNK2A1,EFNB3B,DPYSL2,EPHA4,GNAI3,PEA15A |
| Factors involved in megakaryocyte development and platelet production | HBB-BH1,BA2,HBD,KIF3C,AKAP1,MFN2,HBBE2,IRF2,MAFF,DOCK7 |
| Bacterial invasion of epithelial cells | ARPC2,ARPC4,PIK3R5,RHOG,CAV1,CLTA,DNM3,CAV2,PIK3R1,PIK3CD |
| Fcgamma receptor (FCGR) dependent phagocytosis | ABI2,ACTR2B,WIPF3,ACTR3,MYO9B,NCKIPSD,WASF3,ARPC1A,WASF2,BAIAP2 |
Protein Function
DOCK1 has several biochemical functions, for example, GTPase activator activity,SH3 domain binding,guanyl-nucleotide exchange factor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DOCK1 itself. We selected most functions DOCK1 had, and list some proteins which have the same functions with DOCK1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| GTPase activator activity | RABEP1,RAB3GAP2,ARAP3,RAP1GAP2A,ARHGAP4A,USP6NL,TBC1D8,RIC8A,SGSM3,ASAP1 |
| guanyl-nucleotide exchange factor activity | ARHGEF19,ARHGEF39,DENND1C,DOCK4,RASGRP3,RABIF,ARHGEF7A,ITSN1,RASGEF1C,EIF2B5 |
| SH3 domain binding | INPP5J,ITM2B,MYPN,KHDRBS3,EVLB,QKI,PARK2,SH3BGRL,PAK3,SH2D2A |
| protein binding | CHTOP,MIF4GD,GAL,Ctsl,GALR2,MAB21L1,RDM1,SNX31,HK1,INTS10 |
Interacting Protein
DOCK1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DOCK1 here. Most of them are supplied by our site. Hope this information will be useful for your research of DOCK1.
ELMO1;RAC1
Resources
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References
- Abu-Thuraia, A; Gauthier, R; et al. Axl Phosphorylates Elmo Scaffold Proteins To Promote Rac Activation and Cell Invasion. MOLECULAR AND CELLULAR BIOLOGY 35:76-87(2015).
- Epting, D; Slanchev, K; et al. The Rac1 regulator ELMO controls basal body migration and docking in multiciliated cells through interaction with Ezrin. DEVELOPMENT 142:174-184(2015).
