Active Recombinant Human ABL2, His-tagged
Cat.No. : | ABL2-233H |
Product Overview : | Recombinant human ABL2 (38-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal His tag. |
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Species : | Human |
Source : | Sf9 Cells |
Tag : | His |
Protein Length : | 38-end a.a. |
Description : | This gene encodes a member of the Abelson family of nonreceptor tyrosine protein kinases. The protein is highly similar to the c-abl oncogene 1 protein, including the tyrosine kinase, SH2 and SH3 domains, and it plays a role in cytoskeletal rearrangements through its C-terminal F-actin- and microtubule-binding sequences. This gene is expressed in both normal and tumor cells, and is involved in translocation with the ets variant 6 gene in leukemia. Multiple alternatively spliced transcript variants encoding different protein isoforms have been found for this gene. |
Form : | Recombinant protein stored in 50mM sodium phosphate, pH 7.0, 300mM NaCl, 150mM imidazole, 0.1mM PMSF, 0.25mM DTT, 25% glycerol. |
Bio-activity : | 1218 nmol/min/mg |
Molecular Mass : | ~132 kDa |
AA Sequence : | 38-end |
Purity : | >70% |
Applications : | Kinase Assay, Western Blot |
Stability : | 1 yr at -70°C from date of shipment. |
Storage : | Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. |
Concentration : | 0.1 ug/ul |
Gene Name | ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase [ Homo sapiens (human) ] |
Official Symbol | ABL2 |
Synonyms | ABL2; v-abl Abelson murine leukemia viral oncogene homolog 2; Abelson murine leukemia viral (v-abl) oncogene homolog 2; OTTHUMP00000033140; OTTHUMP00000218106; abelson murine leukemia viral oncogene homolog 2; abelson-related gene protein; arg tyrosine kinase; tyrosine-protein kinase ABL2; tyrosine-protein kinase ARG; v-abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson-related gene); ARG; ABLL; FLJ22224; FLJ31718; FLJ41441; ABL2; EC 2.7.10.2 |
Gene ID | 27 |
mRNA Refseq | NM_005158 |
Protein Refseq | NP_005149 |
MIM | 164690 |
UniProt ID | P42684 |
Chromosome Location | 1q25.2 |
Pathway | Developmental Biology; ErbB signaling pathway; Role of Abl in Robo-Slit signaling |
Function | ATP binding; magnesium ion binding; non-membrane spanning protein tyrosine kinase activity; protein binding |
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ABL2-233H | Active Recombinant Human ABL2, His-tagged | +Inquiry |
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Not For Human Consumption!
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