Abl2
-
Official Full Name
v-abl Abelson murine leukemia viral oncogene homolog 2 -
Overview
This gene encodes a member of the Abelson family of nonreceptor tyrosine protein kinases. The protein is highly similar to the c-abl oncogene 1 protein, including the tyrosine kinase, SH2 and SH3 domains, and it plays a role in cytoskeletal rearrangements through its C-terminal F-actin- and microtubule-binding sequences. This gene is expressed in both normal and tumor cells, and is involved in translocation with the ets variant 6 gene in leukemia. Multiple alternatively spliced transcript variants encoding different protein isoforms have been found for this gene. -
Synonyms
ABL2;v-abl Abelson murine leukemia viral oncogene homolog 2;ABLL, v abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson related gene);Abelson tyrosine-protein kinase 2;Abelson related gene;ARG;tyrosine-protein kinase ARG;abelson-rel
Recombinant Proteins
- Human
- Mouse
- Zebrafish
- Insect Cell
- Sf9 Insect Cell
- Wheat Germ
- Mammalian Cell
- E.coli
- HEK293
- HEK293T
- His
- GST
- Non
- Myc&DDK
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| ABL2-105H |
Active Recombinant Human ABL2 Protein, His-Tagged
|
Insect Cell | Human | His | 38-end a.a. |
|
| ABL2-233H |
Active Recombinant Human ABL2, His-tagged
|
Sf9 Insect Cell | Human | His | 38-end a.a. |
|
| ABL2-106H | Recombinant Human ABL2 Protein, GST-Tagged | Wheat Germ | Human | GST |
|
|
| Abl2-233M | Recombinant Mouse Abl2, His-tagged, Active | Sf9 Insect Cell | Mouse | His | 38-end a.a. |
|
| ABL2-6578Z | Recombinant Zebrafish ABL2 | Mammalian Cell | Zebrafish | His |
|
|
| ABL2-673H | Recombinant Human ABL2, GST-tagged | Insect Cell | Human | GST |
|
|
| ARG-3620M | Recombinant Mouse ARG, His-tagged | E.coli | Mouse | His | 323 |
|
| ABL2-9126HCL | Recombinant Human ABL2 293 Cell Lysate | HEK293 | Human | Non |
|
|
| Abl2-502M | Recombinant Mouse Abl2 Protein, MYC/DDK-tagged | HEK293T | Mouse | Myc&DDK |
|
|
| ABL2-5208H | Recombinant Human ABL2 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293T | Human | Myc&DDK |
|
Involved Pathway
Abl2 involved in several pathways and played different roles in them. We selected most pathways Abl2 participated on our site, such as ErbB signaling pathway,Ras signaling pathway,Viral myocarditis, which may be useful for your reference. Also, other proteins which involved in the same pathway with Abl2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| ErbB signaling pathway | PAK4,PTK2,MAP2K4B,GRB2,MAPK9,MAP2K7,ERBB3A,PIK3R1,SRC,PIK3CD |
| Viral myocarditis | HLA-DMA,ABL1,HLA-DRB5,H2-AB1,ACTG1,ITGAL,ITGB2L,HLA-DQA2,HLA-B,RAC2 |
| Ras signaling pathway | KIT,RASSF1,INSR,KITLG,FLT4,PRKCB,NRAS,VEGFC,FGF16,RGL2 |
Protein Function
Abl2 has several biochemical functions, for example, ATP binding,actin filament binding,actin monomer binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Abl2 itself. We selected most functions Abl2 had, and list some proteins which have the same functions with Abl2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein tyrosine kinase activity | KITA,ERBB2,PTK7,EPHB3A,PTK2B,BTK,MAP3K9,MAP2K2,MATK,TESK2 |
| actin monomer binding | MKL1B,TMSB10,ABL1,MYL3,MYL2,MTSS1,TMSB15B,TMSB4Y,TWF1,MKL1 |
| protein binding | FAM83A,NCOA5,MZF1,TNFRSF10B,ATG101,FOXC1,PPP1R16A,CEACAM6,FSTL5,RICTOR |
| protein kinase activity | RIPK1L,FASTKD1,MAPK12B,FASTKD2,POMK,SGK196,PKZ,CCL8,DAPK2A,CAMK2D1 |
| manganese ion binding | ENDOU,GALNT3,PPM1AB,PCK1,MRE11A,IMPA1,CDIPT,PPEF1,PPM1B,B4GALT1 |
| receptor binding | TMEM38A,ANG,DDX54,ARPP19A,HLA-G,PECI,TNFSF10,NPY,LIF,CX3CL1 |
| non-membrane spanning protein tyrosine kinase activity | PTK2AA,BAZ1B,ZNF143B,SRMS,SRC,BTK,DYRK1A,WEE1,STYK1,EIF2AK2 |
| ATP binding | CLPB,CHTF18,VPS4A,DDX5,DNAH5,FRK,FLT3,CSF1RA,ATP2A3,EPRS |
| actin filament binding | MYH3,CORO1CA,ACTN2B,FLNC,AASS,VIL1,PLS1,SVIL,CORO2B,MYO6 |
Interacting Protein
Abl2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Abl2 here. Most of them are supplied by our site. Hope this information will be useful for your research of Abl2.
CRK;PLCG1;EGFR;NCK1
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References
- Pershad, K; Pavlovic, JD; et al. Generating a panel of highly specific antibodies to 20 human SH2 domains by phage display. PROTEIN ENGINEERING DESIGN & SELECTION 23:279-288(2010).
- Liu, M; Oh, A; et al. Peptidylarginine deiminase (PAD) is a mouse cortical granule protein that plays a role in preimplantation embryonic development. REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY 3:-(2005).
