Active Recombinant Human ABL2 Protein, His-Tagged

• Cat.No.: ABL2-105H
• Product Overview: Human ABL2 (NM_005158, 38 a.a. - end) partial recombinant with His tag expressed in Sf9 cells.

Specification

• Species: Human
• Source: Insect Cells
• Tag: His
• Protein Length: 38-end a.a.
• Description: This gene encodes a member of the Abelson family of nonreceptor tyrosine protein kinases. The protein is highly similar to the c-abl oncogene 1 protein, including the tyrosine kinase, SH2 and SH3 domains, and it plays a role in cytoskeletal rearrangements through its C-terminal F-actin- and microtubule-binding sequences. This gene is expressed in both normal and tumor cells, and is involved in translocation with the ets variant 6 gene in leukemia. Multiple alternatively spliced transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, Nov 2009]
• Bio-activity: The specific activity was determined to be 1218 nmol /min/mg as per Activity Assay Protocol.
• Molecular Mass: 132 kDa
• Purity: > 70% by densitometry
• Applications: Functional Study
  SDS-PAGE
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: In 50 mM Tris-HCl, 150 mM NaCl, pH 7.5 (0.25 mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, 25% glycerol)

Gene Information

• Gene Name: ABL2 v-abl Abelson murine leukemia viral oncogene homolog 2 [ Homo sapiens ]
• Official Symbol: ABL2
• Synonyms: ABL2; v-abl Abelson murine leukemia viral oncogene homolog 2; ABLL, v abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson related gene); Abelson tyrosine-protein kinase 2; Abelson related gene; ARG; tyrosine-protein kinase ARG; abelson-related gene protein; ABLL
• Gene ID: 27
• mRNA Refseq: NM_001136000
• Protein Refseq: NP_001129472
• MIM: 164690
• UniProt ID: P42684