Recombinant Mouse Abl2, His-tagged, Active

• Cat.No.: Abl2-233M
• Product Overview: Recombinant mouse ABL2 (38-end) was expressed by baculovirus inSf9 insect cellsusing an N-terminal His tag. MW=132kDa.

Specification

• Cat. No.: Abl2-233M
• Description: ABL2 (or ARG) is a nonreceptor cytoplasmic tyrosine kinase which is closely related to but distinct from ABL1. The similarity of ABL1 and ABL2 includes the tyrosine kinase domains and extends amino-terminal to include the SH2 and SH3 domains. ABL2 is involved in translocation with the ETV6 gene in human leukemia and has an altered expression in several human carcinomas. Two isoforms of ABL2 with different N-termini (1A and 1B) have been identified. The C-terminal domain of ABL2 contains two F-actin-binding sequences that perform a number of actions related to cell morphology and motility by interacting with actin filaments.
• Source: Sf9 insect cells.
• Sequence: 38-end.
• Applications: Kinase Assay, Western Blot.
• Stability: Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
• Protein length: 38-end a.a.

Gene Information

• Gene Name: Abl2 v-abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson-related gene) [ Mus musculus ]
• Synonyms: Abl2; v-abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson-related gene); Arg; Abll; AA536808; MGC169395; Abelson-related gene protein
• Gene ID: 11352
• mRNA Refseq: NM_001136104
• Protein Refseq: NP_001129576
• UniProt ID: Q4JIM5
• Chromosome Location: 1 G3-H1; 1 82.1 cM
• Pathway: ErbB signaling pathway
• Function: ATP binding; magnesium ion binding; non-membrane spanning protein tyrosine kinase activity; nucleotide binding; protein domain specific binding; protein kinase activity; protein tyrosine kinase activity; transferase activity