WNT3A
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Official Full Name
wingless-type MMTV integration site family, member 3A -
Overview
The Wnt family includes several secreted glycoproteins that play important roles in animal development. There are 19 Wnt genes in the human genome that encode functionally distinct Wnt proteins. Wnt members bind to the Frizzled family of seven-pass transm -
Synonyms
WNT3A;wingless-type MMTV integration site family, member 3A;protein Wnt-3a;MGC119418;MGC119419;MGC119420
Recombinant Proteins
- Human
- Mouse
- Murine
- Zebrafish
- Chicken
- Cattle
- Rat
- E. coli
- Insect Cell
- CHO
- HEK293
- E.coli
- Yeast
- Mammalian Cell
- Human Cell
- Wheat Germ
- Human cells
- Mouse cells
- In Vitro Cell Free System
- Mammalian cells
- N-GST
- Non
- Fc
- His&S
- His
- StrepII
- GST
- N-His
- His&Fc&Avi
- His&T7
Involved Pathway
WNT3A involved in several pathways and played different roles in them. We selected most pathways WNT3A participated on our site, such as Wnt signaling pathway,Hedgehog signaling pathway,Hippo signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with WNT3A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Wnt signaling pathway | WNT7A,PPP3CCB,CHD8,DAAM2,PRKACB,WNT11,ROCK2,CUL1B,NLK1,SIAH1A |
| Basal cell carcinoma | SMO,PTCH2,WNT5A,WNT7A,WNT2B,DVL2,FZD7,SUFU,FZD10,AXIN2 |
| HTLV-I infection | PPP3CC,HLA-DQB1,MSX1,PDGFRB,HLA-C,PIK3CD,TNFRSF1A,TBP,TP53,GPS2 |
| Proteoglycans in cancer | PPP1CA,PPP1R12A,WNT9A,AKT1,MAP2K2,FAS,PRKACB,WNT7B,MMP9,ITGA5 |
| MicroRNAs in cancer | IRS2,MTOR,MCL1,FSCN1,BMPR2,SOX4,CDC25A,RPS6KA5,BAK1,TNXB |
| Hedgehog signaling pathway | WNT4,GAS1B,WNT16,CSNK1DB,FBXW11B,ZIC2B,SAP18,FBXW11A,HHIP,BMP2 |
| Melanogenesis | GNAI3,CALM2A,WNT5A,PRKACBA,DCT,PRKCBB,KITA,GSK3AA,MAPK1,FZD8A |
| Signaling pathways regulating pluripotency of stem cells | BMPR1A,GSK3B,FZD6,SMAD2,FGFR1,ISL1,FZD9,WNT7A,NANOG,PIK3R5 |
| Hippo signaling pathway | BMP2,PPP2R2B,BIRC5,Fzd4,WNT7B,CCND2,SOX2,ID1,WNT2,PPP2R1B |
Protein Function
WNT3A has several biochemical functions, for example, frizzled binding,frizzled-2 binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by WNT3A itself. We selected most functions WNT3A had, and list some proteins which have the same functions with WNT3A. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| frizzled binding | FZD7,NDP,WNT7AA,WNT11R,WNT11,DVL3A,WNT9A,WNT7A,WNT5A,WNT9B |
| frizzled-2 binding | WNT5A |
| protein domain specific binding | RAB27A,HIST1H4N,IKBKG,TRIM11,HNRNPM,TNFAIP1,HIST2H4A,YWHABL,ARHGEF4,YWHABB |
| protein binding | DALRD3,APAF1,PODXL2,SBDS,IFT172,GADD45G,ITGB2,FFAR2,COMMD6,C19orf25 |
| receptor agonist activity | SFRP2,CXCL13,WNT3,GREM1,WNT5A,VEGFA,WNT2,WNT7A,WNT10B,NODAL |
| transcription coactivator activity | FHL2,MED16,KLF7,YAP1,SUPT7L,TFDP1A,RBPMS,NCOA1,TAF12,GTF2A2 |
Interacting Protein
WNT3A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with WNT3A here. Most of them are supplied by our site. Hope this information will be useful for your research of WNT3A.
FZD8;LRP6;Fzd8
Resources
Research Area
Early Mesodermal Lineage MarkersWnt Ligands (Wnts)
EMT Induction
Ectodermal Lineage Markers
Mesodermal Lineage Markers
Related Services
Related Products
References
- Chen, Y; Wang, G; et al. Adverse effects of high glucose levels on somite and limb development in avian embryos. FOOD AND CHEMICAL TOXICOLOGY 71:1-9(2014).
- Kim, JT; Liu, CM; et al. Neurotensin, a novel target of Wnt/beta-catenin pathway, promotes growth of neuroendocrine tumor cells. INTERNATIONAL JOURNAL OF CANCER 136:1475-1481(2015).
